A new benchmark illustrates that integration of geometric constraints inferred from enzyme reaction chemistry can increase enzyme active site modeling accuracy

por Bertolani, Steve J., Siegel, Justin B.
Publicado 2019

A Benchmark for Homomeric Enzyme Active Site Structure Prediction Highlights the Importance of Accurate Modeling of Protein Symmetry

por Contreras, Stephanie C., Bertolani, Steve J., Siegel, Justin B.
Publicado 2019

Computational Drug Design of Novel Agonists of the μ -Opioid Receptor to Inhibit Pain Signaling

por Daoud, Nancy, Mateos, Diego Lopez, Riley, Mary A., Siegel, Justin B.
Publicado 2023

Brewers’ Spent Grain: An Unprecedented Opportunity to Develop Sustainable Plant-Based Nutrition Ingredients Addressing Global Malnutrition Challenges

por Nyhan, Laura, Sahin, Aylin W., Schmitz, Harold H., Siegel, Justin B., Arendt, Elke K.
Publicado 2023

β-Glucosidase Discovery and Design for the Degradation of Oleuropein

por Guggenheim, Kathryn G., Crawford, Lauren M., Paradisi, Francesca, Wang, Selina C., Siegel, Justin B.
Publicado 2018

Investigation of Acid–Base Catalysis in Halimadienyl Diphosphate Synthase Involved in Mycobacterium tuberculosis Virulence

por Lemke, Cody, Roach, Kristin, Ortega, Teresa, Tantillo, Dean J., Siegel, Justin B., Peters, Reuben J.
Publicado 2022

Foldit Standalone: a video game-derived protein structure manipulation interface using Rosetta

por Kleffner, Robert, Flatten, Jeff, Leaver-Fay, Andrew, Baker, David, Siegel, Justin B, Khatib, Firas, Cooper, Seth
Publicado 2017

Preliminary Techno-Economic Assessment of Animal Cell-Based Meat

por Risner, Derrick, Li, Fangzhou, Fell, Jason S., Pace, Sara A., Siegel, Justin B., Tagkopoulos, Ilias, Spang, Edward S.
Publicado 2020

Evaluating Protein Engineering Thermostability Prediction Tools Using an Independently Generated Dataset

por Huang, Peishan, Chu, Simon K. S., Frizzo, Henrique N., Connolly, Morgan P., Caster, Ryan W., Siegel, Justin B.
Publicado 2020

Systematic Functional Analysis of Active-Site Residues in l-Threonine Dehydrogenase from Thermoplasma volcanium

por Desjardins, Morgan, Mak, Wai Shun, O’Brien, Terrence E., Carlin, Dylan Alexander, Tantillo, Dean J., Siegel, Justin B.
Publicado 2017

Integrative genomic mining for enzyme function to enable engineering of a non-natural biosynthetic pathway

por Mak, Wai Shun, Tran, Stephen, Marcheschi, Ryan, Bertolani, Steve, Thompson, James, Baker, David, Liao, James C., Siegel, Justin B.
Publicado 2015

Corrigendum: Integrative genomic mining for enzyme function to enable engineering of a non-natural biosynthetic pathway

por Mak, Wai Shun, Tran, Stephen, Marcheschi, Ryan, Bertolani, Steve, Thompson, James, Baker, David, Liao, James C., Siegel, Justin B.
Publicado 2016

Shifting Redox Reaction Equilibria on Demand Using an Orthogonal Redox Cofactor

por Aspacio, Derek, Zhang, Yulai, Cui, Youtian, King, Edward, Black, William B., Perea, Sean, Luu, Emma, Siegel, Justin B., Li, Han
Publicado 2023

Thermal stability and kinetic constants for 129 variants of a family 1 glycoside hydrolase reveal that enzyme activity and stability can be separately designed

por Carlin, Dylan Alexander, Hapig-Ward, Siena, Chan, Bill Wayne, Damrau, Natalie, Riley, Mary, Caster, Ryan W., Bethards, Bowen, Siegel, Justin B.
Publicado 2017

Orthogonal glycolytic pathway enables directed evolution of noncanonical cofactor oxidase

por King, Edward, Maxel, Sarah, Zhang, Yulai, Kenney, Karissa C., Cui, Youtian, Luu, Emma, Siegel, Justin B., Weiss, Gregory A., Luo, Ray, Li, Han
Publicado 2022

Increased Diels-Alderase Activity through Foldit Player Guided Backbone Remodeling

por Eiben, Christopher B., Siegel, Justin B., Bale, Jacob B., Cooper, Seth, Khatib, Firas, Shen, Betty W., Players, Foldit, Stoddard, Barry L., Popovic, Zoran, Baker, David
Publicado 2012

Missing a “Missing Self” Mechanism: Modeling and Detection of Ly49 Expression in Canine NK Cells

por Gingrich, Alicia A., Razmara, Aryana M., Gingrich, Phillip W., Rebhun, Robert B., Murphy, William J., Kent, Michael S., Brown, C. Titus, Siegel, Justin B., Canter, Robert J.
Publicado 2023

Computational Design of an α-Gliadin Peptidase

por Gordon, Sydney R., Stanley, Elizabeth J., Wolf, Sarah, Toland, Angus, Wu, Sean J., Hadidi, Daniel, Mills, Jeremy H., Baker, David, Pultz, Ingrid Swanson, Siegel, Justin B.
Publicado 2012

High-throughput mutagenesis reveals unique structural features of human ADAR1

por Park, SeHee, Doherty, Erin E., Xie, Yixuan, Padyana, Anil K., Fang, Fang, Zhang, Yue, Karki, Agya, Lebrilla, Carlito B., Siegel, Justin B., Beal, Peter A.
Publicado 2020

Directed evolution of phosphite dehydrogenase to cycle noncanonical redox cofactors via universal growth selection platform

por Zhang, Linyue, King, Edward, Black, William B., Heckmann, Christian M., Wolder, Allison, Cui, Youtian, Nicklen, Francis, Siegel, Justin B., Luo, Ray, Paul, Caroline E., Li, Han
Publicado 2022