Translating from mouse to man to better understand immune-mediated inflammatory diseases

por Aschenbrenner, Dominik, Siegel, Richard M.
Publicado 2023

Falling into TRAPS – receptor misfolding in the TNF receptor 1-associated periodic fever syndrome

por Kimberley, Fiona C, Lobito, Adrian A, Siegel, Richard M, Screaton, Gavin R
Publicado 2007

Fas Ligand localizes to intraluminal vesicles within NK cell cytolytic granules and is enriched at the immune synapse

por Lee, Jeansun, Dieckmann, Nele M.G., Edgar, James R., Griffiths, Gillian M., Siegel, Richard M.
Publicado 2018

Analysis of serum proteomics data identifies a quantitative association between beta-defensin 2 at baseline and clinical response to IL-17 blockade in psoriatic arthritis

por Cardner, Mathias, Tuckwell, Danny, Kostikova, Anna, Forrer, Pascal, Siegel, Richard M, Marti, Alain, Vandemeulebroecke, Marc, Ferrero, Enrico
Publicado 2023

Death-effector Filaments: Novel Cytoplasmic Structures that Recruit Caspases and Trigger Apoptosis

por Siegel, Richard M., Martin, David A., Zheng, Lixin, Ng, Samuel Y., Bertin, John, Cohen, Jeffrey, Lenardo, Michael J.
Publicado 1998

Super-Resolution Imaging of Fas/CD95 Reorganization Induced by Membrane-Bound Fas Ligand Reveals Nanoscale Clustering Upstream of FADD Recruitment

por Frazzette, Nicholas, Cruz, Anthony C., Wu, Xufeng, Hammer, John A., Lippincott-Schwartz, Jennifer, Siegel, Richard M., Sengupta, Prabuddha
Publicado 2022

SPOTS: signaling protein oligomeric transduction structures are early mediators of death receptor–induced apoptosis at the plasma membrane

por Siegel, Richard M., Muppidi, Jagan R., Sarker, Malabika, Lobito, Adrian, Jen, Melinda, Martin, David, Straus, Stephen E., Lenardo, Michael J.
Publicado 2004

Itk is required for Th9 differentiation via TCR-mediated induction of IL-2 and IRF4

por Gomez-Rodriguez, Julio, Meylan, Françoise, Handon, Robin, Hayes, Erika T., Anderson, Stacie M., Kirby, Martha R., Siegel, Richard M., Schwartzberg, Pamela L.
Publicado 2016

Mitochondrial reactive oxygen species promote production of proinflammatory cytokines and are elevated in TNFR1-associated periodic syndrome (TRAPS)

por Bulua, Ariel C., Simon, Anna, Maddipati, Ravikanth, Pelletier, Martin, Park, Heiyoung, Kim, Kye-Young, Sack, Michael N., Kastner, Daniel L., Siegel, Richard M.
Publicado 2011

Targeted genomic analysis reveals widespread autoimmune disease association with regulatory variants in the TNF superfamily cytokine signalling network

por Richard, Arianne C., Peters, James E., Lee, James C., Vahedi, Golnaz, Schäffer, Alejandro A., Siegel, Richard M., Lyons, Paul A., Smith, Kenneth G. C.
Publicado 2016

Critical role of fatty acid metabolism in ILC2-mediated barrier protection during malnutrition and helminth infection

por Wilhelm, Christoph, Harrison, Oliver J., Schmitt, Vanessa, Pelletier, Martin, Spencer, Sean P., Urban, Joseph F., Ploch, Michelle, Ramalingam, Thirumalai R., Siegel, Richard M., Belkaid, Yasmine
Publicado 2016

Reduced monocyte and macrophage TNFSF15/TL1A expression is associated with susceptibility to inflammatory bowel disease

por Richard, Arianne C., Peters, James E., Savinykh, Natalia, Lee, James C., Hawley, Eric T., Meylan, Françoise, Siegel, Richard M., Lyons, Paul A., Smith, Kenneth G. C.
Publicado 2018

Feeding-induced resistance to acute lethal sepsis is dependent on hepatic BMAL1 and FXR signalling

por Geiger, Sarah S., Traba, Javier, Richoz, Nathan, Farley, Taylor K., Brooks, Stephen R., Petermann, Franziska, Wang, Lingdi, Gonzalez, Frank J., Sack, Michael N., Siegel, Richard M.
Publicado 2021

Comparison of gene expression microarray data with count-based RNA measurements informs microarray interpretation

por Richard, Arianne C, Lyons, Paul A, Peters, James E, Biasci, Daniele, Flint, Shaun M, Lee, James C, McKinney, Eoin F, Siegel, Richard M, Smith, Kenneth GC
Publicado 2014

Clinical Evaluation of Melorheostosis in the Context of a Natural History Clinical Study

por Jha, Smita, Cowen, Edward W, Lehky, Tanya J, Alter, Katharine, Flynn, Lauren, Reynolds, James C, Lange, Eileen, Katz, James D, Marini, Joan C, Siegel, Richard M, Bhattacharyya, Timothy
Publicado 2019

Dominant inhibition of Fas ligand-mediated apoptosis due to a heterozygous mutation associated with autoimmune lymphoproliferative syndrome (ALPS) Type Ib

por Bi, Lilia L, Pan, George, Atkinson, T Prescott, Zheng, Lixin, Dale, Janet K, Makris, Christopher, Reddy, Vishnu, McDonald, Jay M, Siegel, Richard M, Puck, Jennifer M, Lenardo, Michael J, Straus, Stephen E
Publicado 2007

Low-density granulocytes activate T cells and demonstrate a non-suppressive role in systemic lupus erythematosus

por Rahman, Saifur, Sagar, Divya, Hanna, Richard N, Lightfoot, Yaima L, Mistry, Pragnesh, Smith, Carolyne K, Manna, Zerai, Hasni, Sarfaraz, Siegel, Richard M, Sanjuan, Miguel A, Kolbeck, Roland, Kaplan, Mariana J, Casey, Kerry A
Publicado 2019

The Fas–FADD death domain complex structure reveals the basis of DISC assembly and disease mutations

por Wang, Liwei, Yang, Jin Kuk, Kabaleeswaran, Venkataraman, Rice, Amanda J., Cruz, Anthony C., Park, Ah Young, Yin, Qian, Damko, Ermelinda, Jang, Se Bok, Raunser, Stefan, Robinson, Carol V., Siegel, Richard M., Walz, Thomas, Wu, Hao
Publicado 2010

Distinct pathogenic roles for resident and monocyte-derived macrophages in lupus nephritis

por Richoz, Nathan, Tuong, Zewen K., Loudon, Kevin W., Patiño-Martínez, Eduardo, Ferdinand, John R., Portet, Anaïs, Bashant, Kathleen R., Thevenon, Emeline, Rucci, Francesca, Hoyler, Thomas, Junt, Tobias, Kaplan, Mariana J., Siegel, Richard M., Clatworthy, Menna R.
Publicado 2023

The TNF-family cytokine TL1A drives IL-13-dependent small intestinal inflammation

por Meylan, Françoise, Song, Yun-Jeong, Fuss, Ivan, Villarreal, Sarah, Kahle, Erin, Malm, Ian-James, Acharya, Krishika, Ramos, Haydee L., Lo, Larry, Mentink-Kane, Margaret M., Wynn, Thomas A., Migone, Thi-Sau, Strober, Warren, Siegel, Richard M.
Publicado 2010