Protein Misfolding and Neurodegenerative Diseases

por Cardinale, Alessio, Chiesa, Roberto, Sierks, Michael
Publicado 2014

A conformation-specific antibody against oligomeric β-amyloid restores neuronal integrity in a mouse model of Alzheimer's disease

por He, Ping, Schulz, Philip, Sierks, Michael R.
Publicado 2021

Curcumin reduces α-synuclein induced cytotoxicity in Parkinson's disease cell model

por Wang, Min S, Boddapati, Shanta, Emadi, Sharareh, Sierks, Michael R
Publicado 2010

Isolation and characterization of antibody fragments selective for human FTD brain derived TDP-43 variants

por Venkataraman, Lalitha, He, Ping, Khan, Galam, Harris, Brent T., Sierks, Michael R.
Publicado 2020

Human α4β2 Nicotinic Acetylcholine Receptor as a Novel Target of Oligomeric α-Synuclein

por Liu, Qiang, Emadi, Sharareh, Shen, Jian-Xin, Sierks, Michael R., Wu, Jie
Publicado 2013

Trimeric Tau Is Toxic to Human Neuronal Cells at Low Nanomolar Concentrations

por Tian, Huilai, Davidowitz, Eliot, Lopez, Patricia, Emadi, Sharareh, Moe, James, Sierks, Michael
Publicado 2013

TDP-43 protein variants as biomarkers in amyotrophic lateral sclerosis

por Williams, Stephanie M., Khan, Galam, Harris, Brent T., Ravits, John, Sierks, Michael R.
Publicado 2017

Sex-Specific Multiparameter Blood Test for the Early Diagnosis of Alzheimer’s Disease

por Cho, Hyung Joon, Schulz, Philip, Venkataraman, Lalitha, Caselli, Richard J., Sierks, Michael R.
Publicado 2022

Conformational Targeting of Fibrillar Polyglutamine Proteins in Live Cells Escalates Aggregation and Cytotoxicity

por Kvam, Erik, Nannenga, Brent L., Wang, Min S., Jia, Zongjian, Sierks, Michael R., Messer, Anne
Publicado 2009

Traumatic brain injury in mice generates early-stage Alzheimer’s disease related protein pathology that correlates with neurobehavioral deficits

por Panayi, Nicholas, Schulz, Philip, He, Ping, Hanna, Brandon, Lifshitz, Jonathan, Rowe, Rachel, Sierks, Michael R
Publicado 2023

Toxic Oligomeric Alpha-Synuclein Variants Present in Human Parkinson’s Disease Brains Are Differentially Generated in Mammalian Cell Models

por Xin, Wei, Emadi, Sharareh, Williams, Stephanie, Liu, Qiang, Schulz, Philip, He, Ping, Alam, Now Bahar, Wu, Jie, Sierks, Michael R.
Publicado 2015

α‐synuclein conformational antibodies fused to penetratin are effective in models of Lewy body disease

por Spencer, Brian, Williams, Stephanie, Rockenstein, Edward, Valera, Elvira, Xin, Wei, Mante, Michael, Florio, Jazmin, Adame, Anthony, Masliah, Eliezer, Sierks, Michael R.
Publicado 2016

ESCRT-mediated Uptake and Degradation of Brain-targeted α-synuclein Single Chain Antibody Attenuates Neuronal Degeneration In Vivo

por Spencer, Brian, Emadi, Sharareh, Desplats, Paula, Eleuteri, Simona, Michael, Sarah, Kosberg, Kori, Shen, Jay, Rockenstein, Edward, Patrick, Christina, Adame, Anthony, Gonzalez, Tania, Sierks, Michael, Masliah, Eliezer
Publicado 2014