Alternative signaling network activation through different insulin receptor family members caused by pro-mitogenic antidiabetic insulin analogues in human mammary epithelial cells

por ter Braak, Bas, Wink, Steven, Koedoot, Esmee, Pont, Chantal, Siezen, Christine, van der Laan, Jan Willem, van de Water, Bob
Publicado 2015

Development of tailored splice-switching oligonucleotides for progressive brain disorders in Europe: development, regulation, and implementation considerations

por Aartsma-Rus, Annemieke, van Roon-Mom, Willeke, Lauffer, Marlen, Siezen, Christine, Duijndam, Britt, Coenen-de Roo, Tineke, Schüle, Rebecca, Synofzik, Matthis, Graessner, Holm
Publicado 2023

Insulin-like growth factor 1 receptor activation promotes mammary gland tumor development by increasing glycolysis and promoting biomass production

por ter Braak, Bas, Siezen, Christine L., Lee, Joo S., Rao, Pooja, Voorhoeve, Charlotte, Ruppin, Eytan, van der Laan, Jan Willem, van de Water, Bob
Publicado 2017

Mammary gland tumor promotion by chronic administration of IGF1 and the insulin analogue AspB10 in the p53(R270H/+)WAPCre mouse model

por ter Braak, Bas, Siezen, Christine, Speksnijder, Ewoud N, Koedoot, Esmee, van Steeg, Harry, Salvatori, Daniela CF, van de Water, Bob, van der Laan, Jan Willem
Publicado 2015

Treatment with insulin (analogues) and breast cancer risk in diabetics; a systematic review and meta-analysis of in vitro, animal and human evidence

por Bronsveld, Heleen K, ter Braak, Bas, Karlstad, Øystein, Vestergaard, Peter, Starup-Linde, Jakob, Bazelier, Marloes T, De Bruin, Marie L, de Boer, Anthonius, Siezen, Christine L E, van de Water, Bob, van der Laan, Jan Willem, Schmidt, Marjanka K
Publicado 2015

Comparison of rat and rabbit embryo–fetal developmental toxicity data for 379 pharmaceuticals: on the nature and severity of developmental effects

por Theunissen, Peter T., Beken, Sonja, Beyer, Bruce K., Breslin, William J., Cappon, Gregg D., Chen, Connie L., Chmielewski, Gary, De Schaepdrijver, Luc, Enright, Brian, Foreman, Jennifer E., Harrouk, Wafa, Hew, Kok-Wah, Hoberman, Alan M., Hui, Julia Y., Knudsen, Thomas B., Laffan, Susan B., Makris, Susan L., Martin, Matt, McNerney, Mary Ellen, Siezen, Christine L., Stanislaus, Dinesh J., Stewart, Jane, Thompson, Kary E., Tornesi, Belen, Van der Laan, Jan Willem, Weinbauer, Gerhard F., Wood, Sandra, Piersma, Aldert H.
Publicado 2016