Developmental Stage-Specific Changes in Protein Synthesis Differentially Sensitize Hematopoietic Stem Cells and Erythroid Progenitors to Impaired Ribosome Biogenesis

por Magee, Jeffrey A., Signer, Robert A.J.
Publicado 2021

Haematopoietic stem cells require a highly regulated protein synthesis rate

por Signer, Robert A.J., Magee, Jeffrey A., Salic, Adrian, Morrison, Sean J.
Publicado 2014

Pten Cell Autonomously Modulates the Hematopoietic Stem Cell Response to Inflammatory Cytokines

por Porter, Shaina N., Cluster, Andrew S., Signer, Robert A.J., Voigtmann, Jenna, Monlish, Darlene A., Schuettpelz, Laura G., Magee, Jeffrey A.
Publicado 2016

Modest Declines in Proteome Quality Impair Hematopoietic Stem Cell Self-Renewal

por Jose, Lorena Hidalgo San, Sunshine, Mary Jean, Dillingham, Christopher H., Chua, Bernadette A., Kruta, Miriama, Hong, Yuning, Hatters, Danny M., Signer, Robert A.J.
Publicado 2020

The rate of protein synthesis in hematopoietic stem cells is limited partly by 4E-BPs

por Signer, Robert A.J., Qi, Le, Zhao, Zhiyu, Thompson, David, Sigova, Alla A., Fan, Zi Peng, DeMartino, George N., Young, Richard A., Sonenberg, Nahum, Morrison, Sean J.
Publicado 2016

CD4 is expressed on a heterogeneous subset of hematopoietic progenitors, which persistently harbor CXCR4 and CCR5-tropic HIV proviral genomes in vivo

por Sebastian, Nadia T., Zaikos, Thomas D., Terry, Valeri, Taschuk, Frances, McNamara, Lucy A., Onafuwa-Nuga, Adewunmi, Yucha, Ryan, Signer, Robert A. J., Riddell IV, James, Bixby, Dale, Markowitz, Norman, Morrison, Sean J., Collins, Kathleen L.
Publicado 2017

Regulation of Mitochondrial Biogenesis in Erythropoiesis by mTORC1-Mediated Protein Translation

por Liu, Xin, Zhang, Yuannyu, Ni, Min, Cao, Hui, Signer, Robert A.J., Li, Dan, Li, Mushan, Gu, Zhimin, Hu, Zeping, Dickerson, Kathryn E., Weinberg, Samuel E., Chandel, Navdeep S., DeBerardinis, Ralph J., Zhou, Feng, Shao, Zhen, Xu, Jian
Publicado 2017