Applications of Quantitative Systems Pharmacology (QSP) in Drug Development for NAFLD and NASH and Its Regulatory Application

por Siler, Scott Q.
Publicado 2022

Comparing the Liver Safety Profiles of 4 Next-Generation CGRP Receptor Antagonists to the Hepatotoxic CGRP Inhibitor Telcagepant Using Quantitative Systems Toxicology Modeling

por Woodhead, Jeffrey L, Siler, Scott Q, Howell, Brett A, Watkins, Paul B, Conway, Charles
Publicado 2022

MITOsym®: A Mechanistic, Mathematical Model of Hepatocellular Respiration and Bioenergetics

por Yang, Y., Nadanaciva, S., Will, Y., Woodhead, J. L., Howell, B. A., Watkins, P. B., Siler, S. Q.
Publicado 2014

Mechanistic Modelling of Drug-Induced Liver Injury: Investigating the Role of Innate Immune Responses

por Shoda, Lisl KM, Battista, Christina, Siler, Scott Q, Pisetsky, David S, Watkins, Paul B, Howell, Brett A
Publicado 2017

A Mechanistic Model of Drug-Induced Liver Injury Aids the Interpretation of Elevated Liver Transaminase Levels in a Phase I Clinical Trial

por Howell, B A, Siler, S Q, Shoda, L K M, Yang, Y, Woodhead, J L, Watkins, P B
Publicado 2014

Using Quantitative Systems Toxicology to Investigate Observed Species Differences in CKA-Mediated Hepatotoxicity

por Battista, Christina, Yang, Kyunghee, Stahl, Simone H, Mettetal, Jerome T, Watkins, Paul B, Siler, Scott Q, Howell, Brett A
Publicado 2018

Exploring BSEP inhibition-mediated toxicity with a mechanistic model of drug-induced liver injury

por Woodhead, Jeffrey L., Yang, Kyunghee, Siler, Scott Q., Watkins, Paul B., Brouwer, Kim L. R., Barton, Hugh A., Howell, Brett A.
Publicado 2014

Analyzing the Mechanisms Behind Macrolide Antibiotic-Induced Liver Injury Using Quantitative Systems Toxicology Modeling

por Woodhead, Jeffrey L., Yang, Kyunghee, Oldach, David, MacLauchlin, Chris, Fernandes, Prabhavathi, Watkins, Paul B., Siler, Scott Q., Howell, Brett A.
Publicado 2019

Investigating bile acid-mediated cholestatic drug-induced liver injury using a mechanistic model of multidrug resistance protein 3 (MDR3) inhibition

por Beaudoin, James J., Yang, Kyunghee, Adiwidjaja, Jeffry, Taneja, Guncha, Watkins, Paul B., Siler, Scott Q., Howell, Brett A., Woodhead, Jeffrey L.
Publicado 2023

Considerations for Physiologically Based Modeling in Liver Disease: From Nonalcoholic Fatty Liver (NAFL) to Nonalcoholic Steatohepatitis (NASH)

por Murphy, William A., Adiwidjaja, Jeffry, Sjöstedt, Noora, Yang, Kyunghee, Beaudoin, James J., Spires, Jessica, Siler, Scott Q., Neuhoff, Sibylle, Brouwer, Kim L.R.
Publicado 2022

Mechanistic Modeling Reveals the Critical Knowledge Gaps in Bile Acid–Mediated DILI

por Woodhead, J L, Yang, K, Brouwer, K L R, Siler, S Q, Stahl, S H, Ambroso, J L, Baker, D, Watkins, P B, Howell, B A
Publicado 2014

Quantitative Systems Toxicology Analysis of In Vitro Mechanistic Assays Reveals Importance of Bile Acid Accumulation and Mitochondrial Dysfunction in TAK-875-Induced Liver Injury

por Longo, Diane M, Woodhead, Jeffrey L, Walker, Paul, Herédi-Szabó, Krisztina, Mogyorósi, Károly, Wolenski, Francis S, Dragan, Yvonne P, Mosedale, Merrie, Siler, Scott Q, Watkins, Paul B, Howell, Brett A
Publicado 2019

Modeling Drug- and Chemical-Induced Hepatotoxicity with Systems Biology Approaches

por Bhattacharya, Sudin, Shoda, Lisl K.M., Zhang, Qiang, Woods, Courtney G., Howell, Brett A., Siler, Scott Q., Woodhead, Jeffrey L., Yang, Yuching, McMullen, Patrick, Watkins, Paul B., Andersen, Melvin E.
Publicado 2012

Prediction of Safety Margin and Optimization of Dosing Protocol for a Novel Antibiotic using Quantitative Systems Pharmacology Modeling

por Woodhead, Jeffrey L., Paech, Franziska, Maurer, Martina, Engelhardt, Marc, Schmitt‐Hoffmann, Anne H., Spickermann, Jochen, Messner, Simon, Wind, Mathias, Witschi, Anne‐Therese, Krähenbühl, Stephan, Siler, Scott Q., Watkins, Paul B., Howell, Brett A.
Publicado 2018

Quantitative systems toxicology (QST) reproduces species differences in PF‐04895162 liver safety due to combined mitochondrial and bile acid toxicity

por Generaux, Grant, Lakhani, Vinal V., Yang, Yuching, Nadanaciva, Sashi, Qiu, Luping, Riccardi, Keith, Di, Li, Howell, Brett A., Siler, Scott Q., Watkins, Paul B., Barton, Hugh A., Aleo, Michael D., Shoda, Lisl K. M.
Publicado 2019

The Combination of a Human Biomimetic Liver Microphysiology System with BIOLOGXsym, a Quantitative Systems Toxicology (QST) Modeling Platform for Macromolecules, Provides Mechanist...

por Beaudoin, James J., Clemens, Lara, Miedel, Mark T., Gough, Albert, Zaidi, Fatima, Ramamoorthy, Priya, Wong, Kari E., Sarangarajan, Rangaprasad, Battista, Christina, Shoda, Lisl K. M., Siler, Scott Q., Taylor, D. Lansing, Howell, Brett A., Vernetti, Lawrence A., Yang, Kyunghee
Publicado 2023

Application of a Mechanistic Model to Evaluate Putative Mechanisms of Tolvaptan Drug-Induced Liver Injury and Identify Patient Susceptibility Factors

por Woodhead, Jeffrey L., Brock, William J., Roth, Sharin E., Shoaf, Susan E., Brouwer, Kim L.R., Church, Rachel, Grammatopoulos, Tom N., Stiles, Linsey, Siler, Scott Q., Howell, Brett A., Mosedale, Merrie, Watkins, Paul B., Shoda, Lisl K.M.
Publicado 2017