Low Adenovirus Vaccine Doses Administered to Skin Using Microneedle Patches Induce Better Functional Antibody Immunogenicity as Compared to Systemic Injection

por Flynn, Olivia, Dillane, Kate, Lanza, Juliane Sousa, Marshall, Jennifer M., Jin, Jing, Silk, Sarah E., Draper, Simon J., Moore, Anne C.
Publicado 2021

Assessment of precision in growth inhibition assay (GIA) using human anti-PfRH5 antibodies

por Miura, Kazutoyo, Diouf, Ababacar, Fay, Michael P., Barrett, Jordan R., Payne, Ruth O., Olotu, Ally I., Minassian, Angela M., Silk, Sarah E., Draper, Simon J., Long, Carole A.
Publicado 2023

Kinetics of antibody responses to PfRH5-complex antigens in Ghanaian children with Plasmodium falciparum malaria

por Partey, Frederica D., Castberg, Filip C., Sarbah, Edem W., Silk, Sarah E., Awandare, Gordon A., Draper, Simon J., Opoku, Nicholas, Kweku, Margaret, Ofori, Michael F., Hviid, Lars, Barfod, Lea
Publicado 2018

Correction: Kinetics of antibody responses to PfRH5-complex antigens in Ghanaian children with Plasmodium falciparum malaria

por Partey, Frederica D., Castberg, Filip C., Sarbah, Edem W., Silk, Sarah E., Awandare, Gordon A., Draper, Simon J., Opoku, Nicholas, Kweku, Margaret, Ofori, Michael F., Hviid, Lars, Barfod, Lea
Publicado 2018

Harmonization study between three laboratories for expression of malaria vaccine clinical trial IgG antibody ELISA data in µg/mL

por Labbé, Geneviève M., Miura, Kazutoyo, Silk, Sarah E., Gu, Wenjuan, Moon, James E., Jin, Jing, Payne, Ruth O., Fay, Michael P., Dutta, Sheetij, Long, Carole A., Draper, Simon J.
Publicado 2019

Antibodies from malaria-exposed Malians generally interact additively or synergistically with human vaccine-induced RH5 antibodies

por Willcox, Alexandra C., Huber, Alex S., Diouf, Ababacar, Barrett, Jordan R., Silk, Sarah E., Pulido, David, King, Lloyd D.W., Alanine, Daniel G.W., Minassian, Angela M., Diakite, Mahamadou, Draper, Simon J., Long, Carole A., Miura, Kazutoyo
Publicado 2021

Identification and Immune Assessment of T Cell Epitopes in Five Plasmodium falciparum Blood Stage Antigens to Facilitate Vaccine Candidate Selection and Optimization

por Kotraiah, Vinayaka, Phares, Timothy W., Terry, Frances E., Hindocha, Pooja, Silk, Sarah E., Nielsen, Carolyn M., Moise, Leonard, Tucker, Kenneth D., Ashfield, Rebecca, Martin, William D., De Groot, Anne S., Draper, Simon J., Gutierrez, Gabriel M., Noe, Amy R.
Publicado 2021

A systematic analysis of the human immune response to Plasmodium vivax

por Bach, Florian A., Muñoz Sandoval, Diana, Mazurczyk, Michalina, Themistocleous, Yrene, Rawlinson, Thomas A., Harding, Adam C., Kemp, Alison, Silk, Sarah E., Barrett, Jordan R., Edwards, Nick J., Ivens, Alasdair, Rayner, Julian C., Minassian, Angela M., Napolitani, Giorgio, Draper, Simon J., Spence, Philip J.
Publicado 2023

Poor CD4(+) T Cell Immunogenicity Limits Humoral Immunity to P. falciparum Transmission-Blocking Candidate Pfs25 in Humans

por Zaric, Marija, Marini, Arianna, Nielsen, Carolyn M., Gupta, Gaurav, Mekhaiel, David, Pham, Thao P., Elias, Sean C., Taylor, Iona J., de Graaf, Hans, Payne, Ruth O., Li, Yuanyuan, Silk, Sarah E., Williams, Chris, Hill, Adrian V. S., Long, Carole A., Miura, Kazutoyo, Biswas, Sumi
Publicado 2021

Better Epitope Discovery, Precision Immune Engineering, and Accelerated Vaccine Design Using Immunoinformatics Tools

por De Groot, Anne S., Moise, Leonard, Terry, Frances, Gutierrez, Andres H., Hindocha, Pooja, Richard, Guilhem, Hoft, Daniel Fredric, Ross, Ted M., Noe, Amy R., Takahashi, Yoshimasa, Kotraiah, Vinayaka, Silk, Sarah E., Nielsen, Carolyn M., Minassian, Angela M., Ashfield, Rebecca, Ardito, Matt, Draper, Simon J., Martin, William D.
Publicado 2020

Production of full-length soluble Plasmodium falciparum RH5 protein vaccine using a Drosophila melanogaster Schneider 2 stable cell line system

por Hjerrild, Kathryn A., Jin, Jing, Wright, Katherine E., Brown, Rebecca E., Marshall, Jennifer M., Labbé, Geneviève M., Silk, Sarah E., Cherry, Catherine J., Clemmensen, Stine B., Jørgensen, Thomas, Illingworth, Joseph J., Alanine, Daniel G. W., Milne, Kathryn H., Ashfield, Rebecca, de Jongh, Willem A., Douglas, Alexander D., Higgins, Matthew K., Draper, Simon J.
Publicado 2016

Accelerating the clinical development of protein-based vaccines for malaria by efficient purification using a four amino acid C-terminal ‘C-tag’

por Jin, Jing, Hjerrild, Kathryn A., Silk, Sarah E., Brown, Rebecca E., Labbé, Geneviève M., Marshall, Jennifer M., Wright, Katherine E., Bezemer, Sandra, Clemmensen, Stine B., Biswas, Sumi, Li, Yuanyuan, El-Turabi, Aadil, Douglas, Alexander D., Hermans, Pim, Detmers, Frank J., de Jongh, Willem A., Higgins, Matthew K., Ashfield, Rebecca, Draper, Simon J.
Publicado 2017

Functional Comparison of Blood-Stage Plasmodium falciparum Malaria Vaccine Candidate Antigens

por Illingworth, Joseph J., Alanine, Daniel G., Brown, Rebecca, Marshall, Jennifer M., Bartlett, Helen E., Silk, Sarah E., Labbé, Geneviève M., Quinkert, Doris, Cho, Jee Sun, Wendler, Jason P., Pattinson, David J., Barfod, Lea, Douglas, Alexander D., Shea, Michael W., Wright, Katherine E., de Cassan, Simone C., Higgins, Matthew K., Draper, Simon J.
Publicado 2019

Protein/AS01(B) vaccination elicits stronger, more Th2-skewed antigen-specific human T follicular helper cell responses than heterologous viral vectors

por Nielsen, Carolyn M., Ogbe, Ane, Pedroza-Pacheco, Isabela, Doeleman, Susanne E., Chen, Yue, Silk, Sarah E., Barrett, Jordan R., Elias, Sean C., Miura, Kazutoyo, Diouf, Ababacar, Bardelli, Martino, Dabbs, Rebecca A., Barfod, Lea, Long, Carole A., Haynes, Barton F., Payne, Ruth O., Minassian, Angela M., Bradley, Todd, Draper, Simon J., Borrow, Persephone
Publicado 2021

A defined mechanistic correlate of protection against Plasmodium falciparum malaria in non-human primates

por Douglas, Alexander D., Baldeviano, G. Christian, Jin, Jing, Miura, Kazutoyo, Diouf, Ababacar, Zenonos, Zenon A., Ventocilla, Julio A., Silk, Sarah E., Marshall, Jennifer M., Alanine, Daniel G. W., Wang, Chuan, Edwards, Nick J., Leiva, Karina P., Gomez-Puerta, Luis A., Lucas, Carmen M., Wright, Gavin J., Long, Carole A., Royal, Joseph M., Draper, Simon J.
Publicado 2019

Mapping immune variation and var gene switching in naive hosts infected with Plasmodium falciparum

por Milne, Kathryn, Ivens, Alasdair, Reid, Adam J, Lotkowska, Magda E, O'Toole, Aine, Sankaranarayanan, Geetha, Munoz Sandoval, Diana, Nahrendorf, Wiebke, Regnault, Clement, Edwards, Nick J, Silk, Sarah E, Payne, Ruth O, Minassian, Angela M, Venkatraman, Navin, Sanders, Mandy J, Hill, Adrian VS, Barrett, Michael, Berriman, Matthew, Draper, Simon J, Rowe, J Alexandra, Spence, Philip J
Publicado 2021

Changes in Serological Immunology Measures in UK and Kenyan Adults Post-controlled Human Malaria Infection

por Hodgson, Susanne H., Llewellyn, David, Silk, Sarah E., Milne, Kathryn H., Elias, Sean C., Miura, Kazutoyo, Kamuyu, Gathoni, Juma, Elizabeth A., Magiri, Charles, Muia, Alfred, Jin, Jing, Spencer, Alexandra J., Longley, Rhea J., Mercier, Thomas, Decosterd, Laurent, Long, Carole A., Osier, Faith H., Hoffman, Stephen L., Ogutu, Bernhards, Hill, Adrian V. S., Marsh, Kevin, Draper, Simon J.
Publicado 2016

Structural basis for inhibition of Plasmodium vivax invasion by a broadly neutralising vaccine-induced human antibody

por Rawlinson, Thomas. A., Barber, Natalie M., Mohring, Franziska, Cho, Jee Sun, Kosaisavee, Varakorn, Gérard, Samuel F., Alanine, Daniel G. W., Labbé, Geneviève M., Elias, Sean C., Silk, Sarah E., Quinkert, Doris, Jin, Jing, Marshall, Jennifer M., Payne, Ruth O., Minassian, Angela M., Russell, Bruce, Rénia, Laurent, Nosten, François H., Moon, Robert W., Higgins, Matthew K., Draper, Simon J.
Publicado 2019

RH5.1-CyRPA-Ripr antigen combination vaccine shows little improvement over RH5.1 in a preclinical setting

por Healer, Julie, Thompson, Jennifer K., Mackwell, Karen L., Browne, Cecille D., Seager, Benjamin A., Ngo, Anna, Lowes, Kym N., Silk, Sarah E., Pulido, David, King, Lloyd D. W., Christen, Jayne M., Noe, Amy R., Kotraiah, Vinayaka, Masendycz, Paul J., Rajagopalan, Rajkannan, Lucas, Leanne, Stanford, Marianne M., Soisson, Lorraine, Diggs, Carter, Miller, Robin, Youll, Susan, Wycherley, Kaye, Draper, Simon J., Cowman, Alan F.
Publicado 2022

Delayed boosting improves human antigen-specific Ig and B cell responses to the RH5.1/AS01(B) malaria vaccine

por Nielsen, Carolyn M., Barrett, Jordan R., Davis, Christine, Fallon, Jonathan K., Goh, Cyndi, Michell, Ashlin R., Griffin, Catherine, Kwok, Andrew, Loos, Carolin, Darko, Samuel, Laboune, Farida, Tekman, Mehmet, Diouf, Ababacar, Miura, Kazutoyo, Francica, Joseph R., Ransier, Amy, Long, Carole A., Silk, Sarah E., Payne, Ruth O., Minassian, Angela M., Lauffenburger, Douglas A., Seder, Robert A., Douek, Daniel C., Alter, Galit, Draper, Simon J.
Publicado 2023