A Role for Both Conformational Selection and Induced Fit in Ligand Binding by the LAO Protein

por Silva, Daniel-Adriano, Bowman, Gregory R., Sosa-Peinado, Alejandro, Huang, Xuhui
Publicado 2011

Quantitatively Characterizing the Ligand Binding Mechanisms of Choline Binding Protein Using Markov State Model Analysis

por Gu, Shuo, Silva, Daniel-Adriano, Meng, Luming, Yue, Alexander, Huang, Xuhui
Publicado 2014

Structural Model of RNA Polymerase II Elongation Complex with Complete Transcription Bubble Reveals NTP Entry Routes

por Zhang, Lu, Silva, Daniel-Adriano, Pardo-Avila, Fátima, Wang, Dong, Huang, Xuhui
Publicado 2015

Structures and disulfide cross‐linking of de novo designed therapeutic mini‐proteins

por Silva, Daniel‐Adriano, Stewart, Lance, Lam, Kwok‐Ho, Jin, Rongsheng, Baker, David
Publicado 2018

Dynamic protein conformations preferentially drive energy transfer along the active chain of the photosystem II reaction centre

por Zhang, Lu, Silva, Daniel-Adriano, Zhang, Houdao, Yue, Alexander, Yan, YiJing, Huang, Xuhui
Publicado 2014

Bridge helix bending promotes RNA polymerase II backtracking through a critical and conserved threonine residue

por Da, Lin-Tai, Pardo-Avila, Fátima, Xu, Liang, Silva, Daniel-Adriano, Zhang, Lu, Gao, Xin, Wang, Dong, Huang, Xuhui
Publicado 2016

131. Antiviral NL-CVX1 Efficiently Blocks Infection of SARS-CoV-2 Viral Variants of Concern (VOC)

por Su, Wen, Walker, Matthew, Rebelo, Maria, Tang, Cong, Coelho, Ana R, Tatalick, Laurie, Riley, Marianne, Yu, Kevin, Blancas-Mejia, Luis M, Silva, Daniel-Adriano, Shoultz, David, Bernardes, Goncalo, Yen, Hui-Ling
Publicado 2021

De novo protein design by citizen scientists

por Koepnick, Brian, Flatten, Jeff, Husain, Tamir, Ford, Alex, Silva, Daniel-Adriano, Bick, Matthew J., Bauer, Aaron, Liu, Gaohua, Ishida, Yojiro, Boykov, Alexander, Estep, Roger D., Kleinfelter, Susan, Nørgård-Solano, Toke, Wei, Linda, Players, Foldit, Montelione, Gaetano T., DiMaio, Frank, Popovic, Zoran, Khatib, Firas, Cooper, Seth, Baker, David
Publicado 2019

A split, conditionally active mimetic of IL-2 reduces the toxicity of systemic cytokine therapy

por Quijano-Rubio, Alfredo, Bhuiyan, Aladdin M., Yang, Huilin, Leung, Isabel, Bello, Elisa, Ali, Lestat R., Zhangxu, Kevin, Perkins, Jilliane, Chun, Jung-Ho, Wang, Wentao, Lajoie, Marc J., Ravichandran, Rashmi, Kuo, Yun-Huai, Dougan, Stephanie K., Riddell, Stanley R., Spangler, Jamie B., Dougan, Michael, Silva, Daniel-Adriano, Baker, David
Publicado 2022

De Novo Human Angiotensin-Converting Enzyme 2 Decoy NL-CVX1 Protects Mice From Severe Disease After Severe Acute Respiratory Syndrome Coronavirus 2 Infection

por Rebelo, Maria, Tang, Cong, Coelho, Ana R, Labão-Almeida, Carlos, Schneider, Matthias M, Tatalick, Laurie, Ruivo, Pedro, de Miranda, Marta Pires, Gomes, Andreia, Carvalho, Tânia, Walker, Matthew J, Ausserwoeger, Hannes, Pedro Simas, J, Veldhoen, Marc, Knowles, Tuomas P J, Silva, Daniel-Adriano, Shoultz, David, Bernardes, Gonçalo J L
Publicado 2023

Computationally designed high specificity inhibitors delineate the roles of BCL2 family proteins in cancer

por Berger, Stephanie, Procko, Erik, Margineantu, Daciana, Lee, Erinna F, Shen, Betty W, Zelter, Alex, Silva, Daniel-Adriano, Chawla, Kusum, Herold, Marco J, Garnier, Jean-Marc, Johnson, Richard, MacCoss, Michael J, Lessene, Guillaume, Davis, Trisha N, Stayton, Patrick S, Stoddard, Barry L, Fairlie, W Douglas, Hockenbery, David M, Baker, David
Publicado 2016

De novo design of modular peptide-binding proteins by superhelical matching

por Wu, Kejia, Bai, Hua, Chang, Ya-Ting, Redler, Rachel, McNally, Kerrie E., Sheffler, William, Brunette, T. J., Hicks, Derrick R., Morgan, Tomos E., Stevens, Tim J., Broerman, Adam, Goreshnik, Inna, DeWitt, Michelle, Chow, Cameron M., Shen, Yihang, Stewart, Lance, Derivery, Emmanuel, Silva, Daniel Adriano, Bhabha, Gira, Ekiert, Damian C., Baker, David
Publicado 2023

De novo design of potent and selective mimics of IL-2 and IL-15

por Silva, Daniel-Adriano, Yu, Shawn, Ulge, Umut, Spangler, Jamie B., Jude, Kevin M., Labão-Almeida, Carlos, Ali, Lestat R., Quijano-Rubio, Alfredo, Ruterbusch, Mikel, Leung, Isabel, Biary, Tamara, Crowley, Stephanie J., Marcos, Enrique, Walkey, Carl D., Weitzner, Brian D., Pardo-Avila, Fátima, Castellanos, Javier, Carter, Lauren, Stewart, Lance, Riddell, Stanley, Pepper, Marion, Bernardes, Gonçalo J. L., Dougan, Michael, Garcia, K. Christopher, Baker, David
Publicado 2019

Design of cell-type-specific hyperstable IL-4 mimetics via modular de novo scaffolds

por Yang, Huilin, Ulge, Umut Y., Quijano-Rubio, Alfredo, Bernstein, Zachary J., Maestas, David R., Chun, Jung-Ho, Wang, Wentao, Lin, Jian-Xin, Jude, Kevin M., Singh, Srujan, Orcutt-Jahns, Brian T., Li, Peng, Mou, Jody, Chung, Liam, Kuo, Yun-Huai, Ali, Yasmin H., Meyer, Aaron S., Grayson, Warren L., Heller, Nicola M., Christopher Garcia, K., Leonard, Warren J., Silva, Daniel-Adriano, Elisseeff, Jennifer H., Baker, David, Spangler, Jamie B.
Publicado 2023

De novo design of potent and resilient hACE2 decoys to neutralize SARS-CoV-2

por Linsky, Thomas W., Vergara, Renan, Codina, Nuria, Nelson, Jorgen W., Walker, Matthew J., Su, Wen, Barnes, Christopher O., Hsiang, Tien-Ying, Esser-Nobis, Katharina, Yu, Kevin, Reneer, Z. Beau, Hou, Yixuan J., Priya, Tanu, Mitsumoto, Masaya, Pong, Avery, Lau, Uland Y., Mason, Marsha L., Chen, Jerry, Chen, Alex, Berrocal, Tania, Peng, Hong, Clairmont, Nicole S., Castellanos, Javier, Lin, Yu-Ru, Josephson-Day, Anna, Baric, Ralph S., Fuller, Deborah H., Walkey, Carl D., Ross, Ted M., Swanson, Ryan, Bjorkman, Pamela J., Gale, Michael, Blancas-Mejia, Luis M., Yen, Hui-Ling, Silva, Daniel-Adriano
Publicado 2020

Super-enhancer-based identification of a BATF3/IL-2R−module reveals vulnerabilities in anaplastic large cell lymphoma

por Liang, Huan-Chang, Costanza, Mariantonia, Prutsch, Nicole, Zimmerman, Mark W., Gurnhofer, Elisabeth, Montes-Mojarro, Ivonne A., Abraham, Brian J., Prokoph, Nina, Stoiber, Stefan, Tangermann, Simone, Lobello, Cosimo, Oppelt, Jan, Anagnostopoulos, Ioannis, Hielscher, Thomas, Pervez, Shahid, Klapper, Wolfram, Zammarchi, Francesca, Silva, Daniel-Adriano, Garcia, K. Christopher, Baker, David, Janz, Martin, Schleussner, Nikolai, Fend, Falko, Pospíšilová, Šárka, Janiková, Andrea, Wallwitz, Jacqueline, Stoiber, Dagmar, Simonitsch-Klupp, Ingrid, Cerroni, Lorenzo, Pileri, Stefano, de Leval, Laurence, Sibon, David, Fataccioli, Virginie, Gaulard, Philippe, Assaf, Chalid, Knörr, Fabian, Damm-Welk, Christine, Woessmann, Wilhelm, Turner, Suzanne D., Look, A. Thomas, Mathas, Stephan, Kenner, Lukas, Merkel, Olaf
Publicado 2021