Advances in Preclinical In Vitro Models for the Translation of Precision Medicine for Cystic Fibrosis

por Silva, Iris A. L., Laselva, Onofrio, Lopes-Pacheco, Miquéias
Publicado 2022

Personalized Medicine Based on Nasal Epithelial Cells: Comparative Studies with Rectal Biopsies and Intestinal Organoids

por Silva, Iris A. L., Railean, Violeta, Duarte, Aires, Amaral, Margarida D.
Publicado 2021

Rare Trafficking CFTR Mutations Involve Distinct Cellular Retention Machineries and Require Different Rescuing Strategies

por Ramalho, Sofia S., Silva, Iris A. L., Amaral, Margarida D., Farinha, Carlos M.
Publicado 2021

Molecular effect of an OPTN common variant associated to Paget's disease of bone

por Silva, Iris A. L., Conceição, Natércia, Gagnon, Édith, Brown, Jacques P., Cancela, M. Leonor, Michou, Laëtitia
Publicado 2018

Pharmacological Modulation of Ion Channels for the Treatment of Cystic Fibrosis

por Pinto, Madalena C, Silva, Iris A L, Figueira, Miriam F, Amaral, Margarida D, Lopes-Pacheco, Miquéias
Publicado 2021

Absence of EPAC1 Signaling to Stabilize CFTR in Intestinal Organoids

por Ferreira, João F., Silva, Iris A. L., Botelho, Hugo M., Amaral, Margarida D., Farinha, Carlos M.
Publicado 2022

Synergy in Cystic Fibrosis Therapies: Targeting SLC26A9

por Pinto, Madalena C., Quaresma, Margarida C., Silva, Iris A. L., Railean, Violeta, Ramalho, Sofia S., Amaral, Margarida D.
Publicado 2021

Additive Potentiation of R334W-CFTR Function by Novel Small Molecules

por Bacalhau, Mafalda, Ferreira, Filipa C., Silva, Iris A. L., Buarque, Camilla D., Amaral, Margarida D., Lopes-Pacheco, Miquéias
Publicado 2023

Assessment of Distinct Electrophysiological Parameters in Rectal Biopsies for the Choice of the Best Diagnosis/Prognosis Biomarkers for Cystic Fibrosis

por Silva, Iris A. L., Duarte, Aires, Marson, Fernando A. L., Centeio, Raquel, Doušová, Tereza, Kunzelmann, Karl, Amaral, Margarida D.
Publicado 2020

Personalized medicine: Function of CFTR variant p.Arg334Trp is rescued by currently available CFTR modulators

por Railean, Violeta, Rodrigues, Cláudia S., Ramalho, Sofia S., Silva, Iris A. L., Bartosch, Jan, Farinha, Carlos M., Pankonien, Ines, Amaral, Margarida D.
Publicado 2023

Mutant CFTR Drives TWIST1 mediated epithelial–mesenchymal transition

por Quaresma, Margarida C., Pankonien, Ines, Clarke, Luka A., Sousa, Luís S., Silva, Iris A. L., Railean, Violeta, Doušová, Tereza, Fuxe, Jonas, Amaral, Margarida D.
Publicado 2020

Rescue of Mutant CFTR Trafficking Defect by the Investigational Compound MCG1516A

por Lopes-Pacheco, Miquéias, Bacalhau, Mafalda, Ramalho, Sofia S., Silva, Iris A. L., Ferreira, Filipa C., Carlile, Graeme W., Thomas, David Y., Farinha, Carlos M., Hanrahan, John W., Amaral, Margarida D.
Publicado 2022

Protocol for Application, Standardization and Validation of the Forskolin-Induced Swelling Assay in Cystic Fibrosis Human Colon Organoids

por Vonk, Annelotte M., van Mourik, Peter, Ramalho, Anabela S., Silva, Iris A.L., Statia, Marvin, Kruisselbrink, Evelien, Suen, Sylvia W.F., Dekkers, Johanna F., Vleggaar, Frank P., Houwen, Roderick H.J., Mullenders, Jasper, Boj, Sylvia F., Vries, Robert, Amaral, Margarida D., de Boeck, Kris, van der Ent, Cornelis K., Beekman, Jeffrey M.
Publicado 2020