How to Connect Cardiac Excitation to the Atomic Interactions of Ion Channels

por Silva, Jonathan R.
Publicado 2018

Multi-scale electrophysiology modeling: from atom to organ

por Silva, Jonathan R., Rudy, Yoram
Publicado 2010

A computationally efficient algorithm for fitting ion channel parameters

por Teed, Zachary R., Silva, Jonathan R.
Publicado 2016

Voltage-sensor movements describe slow inactivation of voltage-gated sodium channels I: Wild-type skeletal muscle Na(V)1.4

por Silva, Jonathan R., Goldstein, Steve A.N.
Publicado 2013

Voltage-sensor movements describe slow inactivation of voltage-gated sodium channels II: A periodic paralysis mutation in Na(V)1.4 (L689I)

por Silva, Jonathan R., Goldstein, Steve A.N.
Publicado 2013

Conservation and divergence in NaChBac and Na(V)1.7 pharmacology reveals novel drug interaction mechanisms

por Zhu, Wandi, Li, Tianbo, Silva, Jonathan R., Chen, Jun
Publicado 2020

Conformations of voltage-sensing domain III differentially define Na(V) channel closed- and open-state inactivation

por Angsutararux, Paweorn, Kang, Po Wei, Zhu, Wandi, Silva, Jonathan R.
Publicado 2021

Molecular Pathology of Sodium Channel Beta-Subunit Variants

por Angsutararux, Paweorn, Zhu, Wandi, Voelker, Taylor L., Silva, Jonathan R.
Publicado 2021

A Molecularly Detailed Na(V)1.5 Model Reveals a New Class I Antiarrhythmic Target

por Moreno, Jonathan D., Zhu, Wandi, Mangold, Kathryn, Chung, Woenho, Silva, Jonathan R.
Publicado 2019

Depolarization of the conductance-voltage relationship in the Na(V)1.5 mutant, E1784K, is due to altered fast inactivation

por Peters, Colin H., Yu, Alec, Zhu, Wandi, Silva, Jonathan R., Ruben, Peter C.
Publicado 2017

Intrinsic mechanisms in the gating of resurgent Na(+) currents

por Ransdell, Joseph L, Moreno, Jonathan D, Bhagavan, Druv, Silva, Jonathan R, Nerbonne, Jeanne M
Publicado 2022

Regulation of Na(+) channel inactivation by the DIII and DIV voltage-sensing domains

por Hsu, Eric J., Zhu, Wandi, Schubert, Angela R., Voelker, Taylor, Varga, Zoltan, Silva, Jonathan R.
Publicado 2017

Mechanisms of noncovalent β subunit regulation of Na(V) channel gating

por Zhu, Wandi, Voelker, Taylor L., Varga, Zoltan, Schubert, Angela R., Nerbonne, Jeanne M., Silva, Jonathan R.
Publicado 2017

Modulation of the effects of class Ib antiarrhythmics on cardiac Na(V)1.5-encoded channels by accessory Na(V)β subunits

por Zhu, Wandi, Wang, Wei, Angsutararux, Paweorn, Mellor, Rebecca L., Isom, Lori L., Nerbonne, Jeanne M., Silva, Jonathan R.
Publicado 2021

Use of a mixed reality system for navigational mapping during cardiac electrophysiological testing does not prolong case duration: A subanalysis from the Cardiac Augmented REality...

por Bloom, David, Catherall, David, Miller, Nathan, Southworth, Michael K., Glatz, Andrew C., Silva, Jonathan R., Avari Silva, Jennifer N.
Publicado 2023

Identification of structures for ion channel kinetic models

por Mangold, Kathryn E., Wang, Wei, Johnson, Eric K., Bhagavan, Druv, Moreno, Jonathan D., Nerbonne, Jeanne M., Silva, Jonathan R.
Publicado 2021

Differential regulation of cardiac sodium channels by intracellular fibroblast growth factors

por Angsutararux, Paweorn, Dutta, Amal K., Marras, Martina, Abella, Carlota, Mellor, Rebecca L., Shi, Jingyi, Nerbonne, Jeanne M., Silva, Jonathan R.
Publicado 2023

Gating control of the cardiac sodium channel Nav1.5 by its β3-subunit involves distinct roles for a transmembrane glutamic acid and the extracellular domain

por Salvage, Samantha C., Zhu, Wandi, Habib, Zaki F., Hwang, Soyon S., Irons, Jennifer R., Huang, Christopher L. H., Silva, Jonathan R., Jackson, Antony P.
Publicado 2019

Early preclinical experience of a mixed reality ultrasound system with active GUIDance for NEedle-based interventions: The GUIDE study

por Bloom, David, Colombo, Jamie N., Miller, Nathan, Southworth, Michael K., Andrews, Christopher, Henry, Alexander, Orr, William B., Silva, Jonathan R., Avari Silva, Jennifer N.
Publicado 2022

Arrhythmia-associated calmodulin variants interact with KCNQ1 to confer aberrant membrane trafficking and function

por Kang, Po wei, Woodbury, Lucy, Angsutararux, Paweorn, Sambare, Namit, Shi, Jingyi, Marras, Martina, Abella, Carlota, Bedi, Anish, Zinn, DeShawn, Cui, Jianmin, Silva, Jonathan R
Publicado 2023