Tauopathies: Deciphering Disease Mechanisms to Develop Effective Therapies

por Silva, M. Catarina, Haggarty, Stephen J.
Publicado 2020

Neuronal Reprograming of Protein Homeostasis by Calcium-Dependent Regulation of the Heat Shock Response

por Silva, M. Catarina, Amaral, Margarida D., Morimoto, Richard I.
Publicado 2013

A Genetic Screening Strategy Identifies Novel Regulators of the Proteostasis Network

por Silva, M. Catarina, Fox, Susan, Beam, Monica, Thakkar, Happy, Amaral, Margarida D., Morimoto, Richard I.
Publicado 2011

Discovery and Optimization of Tau Targeted Protein Degraders Enabled by Patient Induced Pluripotent Stem Cells-Derived Neuronal Models of Tauopathy

por Silva, M. Catarina, Nandi, Ghata, Donovan, Katherine A., Cai, Quan, Berry, Bethany C., Nowak, Radoslaw P., Fischer, Eric S., Gray, Nathanael S., Ferguson, Fleur M., Haggarty, Stephen J.
Publicado 2022

Prolonged tau clearance and stress vulnerability rescue by pharmacological activation of autophagy in tauopathy neurons

por Silva, M. Catarina, Nandi, Ghata A., Tentarelli, Sharon, Gurrell, Ian K., Jamier, Tanguy, Lucente, Diane, Dickerson, Bradford C., Brown, Dean G., Brandon, Nicholas J., Haggarty, Stephen J.
Publicado 2020

Small molecule regulators of microRNAs identified by high-throughput screen coupled with high-throughput sequencing

por Nguyen, Lien D., Wei, Zhiyun, Silva, M. Catarina, Barberán-Soler, Sergio, Zhang, Jiarui, Rabinovsky, Rosalia, Muratore, Christina R., Stricker, Jonathan M. S., Hortman, Colin, Young-Pearse, Tracy L., Haggarty, Stephen J., Krichevsky, Anna M.
Publicado 2023

Targeted degradation of aberrant tau in frontotemporal dementia patient-derived neuronal cell models

por Silva, M Catarina, Ferguson, Fleur M, Cai, Quan, Donovan, Katherine A, Nandi, Ghata, Patnaik, Debasis, Zhang, Tinghu, Huang, Hai-Tsang, Lucente, Diane E, Dickerson, Bradford C, Mitchison, Timothy J, Fischer, Eric S, Gray, Nathanael S, Haggarty, Stephen J
Publicado 2019

Human iPSC-Derived Neuronal Model of Tau-A152T Frontotemporal Dementia Reveals Tau-Mediated Mechanisms of Neuronal Vulnerability

por Silva, M. Catarina, Cheng, Chialin, Mair, Waltraud, Almeida, Sandra, Fong, Helen, Biswas, M. Helal U., Zhang, Zhijun, Huang, Yadong, Temple, Sally, Coppola, Giovanni, Geschwind, Daniel H., Karydas, Anna, Miller, Bruce L., Kosik, Kenneth S., Gao, Fen-Biao, Steen, Judith A., Haggarty, Stephen J.
Publicado 2016

A Cdk5-derived peptide inhibits Cdk5/p25 activity and improves neurodegenerative phenotypes

por Pao, Ping-Chieh, Seo, Jinsoo, Lee, Audrey, Kritskiy, Oleg, Patnaik, Debasis, Penney, Jay, Raju, Ravikiran M., Geigenmuller, Ute, Silva, M. Catarina, Lucente, Diane E., Gusella, James F., Dickerson, Bradford C., Loon, Anjanet, Yu, Margaret X., Bula, Michael, Yu, Melody, Haggarty, Stephen J., Tsai, Li-Huei
Publicado 2023

High-content image-based analysis and proteomic profiling identifies Tau phosphorylation inhibitors in a human iPSC-derived glutamatergic neuronal model of tauopathy

por Cheng, Chialin, Reis, Surya A., Adams, Emily T., Fass, Daniel M., Angus, Steven P., Stuhlmiller, Timothy J., Richardson, Jared, Olafson, Hailey, Wang, Eric T., Patnaik, Debasis, Beauchamp, Roberta L., Feldman, Danielle A., Silva, M. Catarina, Sur, Mriganka, Johnson, Gary L., Ramesh, Vijaya, Miller, Bruce L., Temple, Sally, Kosik, Kenneth S., Dickerson, Bradford C., Haggarty, Stephen J.
Publicado 2021

A Comprehensive Resource for Induced Pluripotent Stem Cells from Patients with Primary Tauopathies

por Karch, Celeste M., Kao, Aimee W., Karydas, Anna, Onanuga, Khadijah, Martinez, Rita, Argouarch, Andrea, Wang, Chao, Huang, Cindy, Sohn, Peter Dongmin, Bowles, Kathryn R., Spina, Salvatore, Silva, M. Catarina, Marsh, Jacob A., Hsu, Simon, Pugh, Derian A., Ghoshal, Nupur, Norton, Joanne, Huang, Yadong, Lee, Suzee E., Seeley, William W., Theofilas, Panagiotis, Grinberg, Lea T., Moreno, Fermin, McIlroy, Kathryn, Boeve, Bradley F., Cairns, Nigel J., Crary, John F., Haggarty, Stephen J., Ichida, Justin K., Kosik, Kenneth S., Miller, Bruce L., Gan, Li, Goate, Alison M., Temple, Sally
Publicado 2019