Novel Combination of Impella and Extra Corporeal Membrane Oxygenation as a Bridge to Full Recovery in Fulminant Myocarditis

por Narain, Sachin, Paparcuri, Gian, Fuhrman, Thomas M., Silverman, Richard B., Peruzzi, William T.
Publicado 2012

Synthesis and enzymatic evaluation of 2- and 4-aminothiazole-based inhibitors of neuronal nitric oxide synthase

por Lawton, Graham R, Ji, Haitao, Martásek, Pavel, Roman, Linda J, Silverman, Richard B
Publicado 2009

Pregabalin Treatment does not Affect Amyloid Pathology in 5XFAD Mice

por Sadleir, Katherine R., Popovoic, Jelena, Zhu, Wei, Reidel, Cory T., Do, Ha, Silverman, Richard B., Vassar, Robert
Publicado 2021

Simplified 2-Aminoquinoline-Based Scaffold for Potent and Selective Neuronal Nitric Oxide Synthase Inhibition

por Cinelli, Maris A., Li, Huiying, Chreifi, Georges, Martásek, Pavel, Roman, Linda J., Poulos, Thomas L., Silverman, Richard B.
Publicado 2014

Inhibition of interferon-gamma-stimulated melanoma progression by targeting neuronal nitric oxide synthase (nNOS)

por Tong, Shirley, Cinelli, Maris A., El-Sayed, Naglaa Salem, Huang, He, Patel, Anika, Silverman, Richard B., Yang, Sun
Publicado 2022

Palladium-Catalyzed α-Arylation of Cyclic β-Dicarbonyl Compounds for the Synthesis of Ca(V)1.3 Inhibitors

por Yun, Jisu, Jeong, Dayeon, Xie, Zhong, Lee, Sol, Kim, Jiho, Surmeier, D. James, Silverman, Richard B., Kang, Soosung
Publicado 2022

Nitric Oxide Synthase Inhibitors That Interact with Both Heme Propionate and Tetrahydrobiopterin Show High Isoform Selectivity

por Kang, Soosung, Tang, Wei, Li, Huiying, Chreifi, Georges, Martásek, Pavel, Roman, Linda J., Poulos, Thomas L., Silverman, Richard B.
Publicado 2014

Novel 2,4-Disubstituted Pyrimidines as Potent, Selective, and Cell-Permeable Inhibitors of Neuronal Nitric Oxide Synthase

por Mukherjee, Paramita, Li, Huiying, Sevrioukova, Irina, Chreifi, Georges, Martásek, Pavel, Roman, Linda J., Poulos, Thomas L., Silverman, Richard B.
Publicado 2014

Enzymatic and Cryoreduction EPR Studies of the Hydroxylation of Methylated N(ω)-Hydroxy-l-arginine Analogues by Nitric Oxide Synthase from Geobacillus stearothermophilus

por Davydov, Roman, Labby, Kristin Jansen, Chobot, Sarah E., Lukoyanov, Dmitriy A., Crane, Brian R., Silverman, Richard B., Hoffman, Brian M.
Publicado 2014

Mechanism of Inactivation of γ-Aminobutyric Acid Aminotransferase by (1S,3S)-3-Amino-4-difluoromethylene-1-cyclopentanoic Acid (CPP-115)

por Lee, Hyunbeom, Doud, Emma H., Wu, Rui, Sanishvili, Ruslan, Juncosa, Jose I., Liu, Dali, Kelleher, Neil L., Silverman, Richard B.
Publicado 2015

NU-9 improves health of hSOD1(G93A) mouse upper motor neurons in vitro, especially in combination with riluzole or edaravone

por Genç, Barış, Gautam, Mukesh, Helmold, Benjamin R., Koçak, Nuran, Günay, Aksu, Goshu, Gashaw M., Silverman, Richard B., Hande Ozdinler, P.
Publicado 2022

Potent and Selective Double-Headed Thiophene-2-carboximidamide Inhibitors of Neuronal Nitric Oxide Synthase for the Treatment of Melanoma

por Huang, He, Li, Huiying, Yang, Sun, Chreifi, Georges, Martásek, Pavel, Roman, Linda J., Meyskens, Frank L., Poulos, Thomas L., Silverman, Richard B.
Publicado 2014

The Mobility of a Conserved Tyrosine Residue Controls Isoform-Dependent Enzyme–Inhibitor Interactions in Nitric Oxide Synthases

por Li, Huiying, Jamal, Joumana, Delker, Silvia, Plaza, Carla, Ji, Haitao, Jing, Qing, Huang, He, Kang, Soosung, Silverman, Richard B., Poulos, Thomas L.
Publicado 2014

Improving mitochondria and ER stability helps eliminate upper motor neuron degeneration that occurs due to mSOD1 toxicity and TDP‐43 pathology

por Genç, Barış, Gautam, Mukesh, Gözütok, Öge, Dervishi, Ina, Sanchez, Santana, Goshu, Gashaw M., Koçak, Nuran, Xie, Edward, Silverman, Richard B., Özdinler, P. Hande
Publicado 2021

A Small Peptide Increases Drug Delivery in Human Melanoma Cells

por Tong, Shirley, Darwish, Shaban, Ariani, Hanieh Hossein Nejad, Lozada, Kate Alison, Salehi, David, Cinelli, Maris A., Silverman, Richard B., Kaur, Kamaljit, Yang, Sun
Publicado 2022

Proteasome Activation is a Mechanism for Pyrazolone Small Molecules Displaying Therapeutic Potential in Amyotrophic Lateral Sclerosis

por Trippier, Paul C., Zhao, Kevin Tianmeng, Fox, Susan G., Schiefer, Isaac T., Benmohamed, Radhia, Moran, Jason, Kirsch, Donald R., Morimoto, Richard I., Silverman, Richard B.
Publicado 2014

Structure-Based Design of Bacterial Nitric Oxide Synthase Inhibitors

por Holden, Jeffrey K., Kang, Soosung, Hollingsworth, Scott A., Li, Huiying, Lim, Nathan, Chen, Steven, Huang, He, Xue, Fengtian, Tang, Wei, Silverman, Richard B., Poulos, Thomas L.
Publicado 2014

Structural and Mechanistic Basis for the Inactivation of Human Ornithine Aminotransferase by (3S,4S)-3-Amino-4-fluorocyclopentenecarboxylic Acid

por Shen, Sida, Butrin, Arseniy, Beaupre, Brett A., Ferreira, Glaucio M., Doubleday, Peter F., Grass, Daniel H., Zhu, Wei, Kelleher, Neil L., Moran, Graham R., Liu, Dali, Silverman, Richard B.
Publicado 2023