POSCAbilities: The Application of the Prion Organotypic Slice Culture Assay to Neurodegenerative Disease Research

por Pineau, Hailey, Sim, Valerie
Publicado 2020

From Cell Culture to Organoids-Model Systems for Investigating Prion Strain Characteristics

por Pineau, Hailey, Sim, Valerie L.
Publicado 2021

Structure-Based Peptide Design to Modulate Amyloid Beta Aggregation and Reduce Cytotoxicity

por Kumar, Jitendra, Namsechi, Risa, Sim, Valerie L.
Publicado 2015

14-3-3 and enolase abundances in the CSF of Prion diseased rats

por Gushue, Danielle, Herbst, Allen, Sim, Valerie, McKenzie, Debbie, Aiken, Judd M.
Publicado 2018

Early Increase and Late Decrease of Purkinje Cell Dendritic Spine Density in Prion-Infected Organotypic Mouse Cerebellar Cultures

por Campeau, Jody L., Wu, Gengshu, Bell, John R., Rasmussen, Jay, Sim, Valerie L.
Publicado 2013

Implications of exosomes derived from cholesterol-accumulated astrocytes in Alzheimer's disease pathology

por Wu, Qi, Cortez, Leonardo, Kamali-Jamil, Razieh, Sim, Valerie, Wille, Holger, Kar, Satyabrata
Publicado 2021

Exposure Risk of Chronic Wasting Disease in Humans

por Nemani, Satish K., Myskiw, Jennifer L., Lamoureux, Lise, Booth, Stephanie A., Sim, Valerie L.
Publicado 2020

Pharmacological chaperone reshapes the energy landscape for folding and aggregation of the prion protein

por Gupta, Amar Nath, Neupane, Krishna, Rezajooei, Negar, Cortez, Leonardo M., Sim, Valerie L., Woodside, Michael T.
Publicado 2016

Creutzfeldt–Jakob Disease with a Five-Year Clinical Course, Multicentric Cerebellar Prion Plaques and Prior History of Biopsy-Proven Primary Angiitis of the Central Nervous System:...

por Jeon, Kristina, Joseph, Jeffrey T., Jansen, Gerard H., Peterson, Anne, Knox, J. David, Sim, Valerie L.
Publicado 2020

Deposition pattern and subcellular distribution of disease-associated prion protein in cerebellar organotypic slice cultures infected with scrapie

por Wolf, Hanna, Hossinger, André, Fehlinger, Andrea, Büttner, Sven, Sim, Valerie, McKenzie, Debbie, Vorberg, Ina M.
Publicado 2015

Quaternary Structure Changes for PrP(Sc) Predate PrP(C) Downregulation and Neuronal Death During Progression of Experimental Scrapie Disease

por Eskandari-Sedighi, Ghazaleh, Cortez, Leonardo M., Yang, Jing, Daude, Nathalie, Shmeit, Klinton, Sim, Valerie, Westaway, David
Publicado 2020

Creutzfeldt–Jakob disease in pregnancy: the use of modified RT-QuIC to determine infectivity in placental tissues

por Luk, Collin C., Mathiason, Candace K., Orrù, Christina D., Jansen, Gerard H., Thiele, Allison, Caughey, Byron, Sim, Valerie L.
Publicado 2021

Infectious Prions Accumulate to High Levels in Non Proliferative C2C12 Myotubes

por Herbst, Allen, Banser, Pamela, Velasquez, Camilo Duque, Mays, Charles E., Sim, Valerie L., Westaway, David, Aiken, Judd M., McKenzie, Debbie
Publicado 2013

Oral administration of repurposed drug targeting Cyp46A1 increases survival times of prion infected mice

por Ali, Tahir, Hannaoui, Samia, Nemani, Satish, Tahir, Waqas, Zemlyankina, Irina, Cherry, Pearl, Shim, Su Yeon, Sim, Valerie, Schaetzl, Hermann M., Gilch, Sabine
Publicado 2021

Asymmetric-flow field-flow fractionation of prions reveals a strain-specific continuum of quaternary structures with protease resistance developing at a hydrodynamic radius of 15 n...

por Cortez, Leonardo M., Nemani, Satish K., Duque Velásquez, Camilo, Sriraman, Aishwarya, Wang, YongLiang, Wille, Holger, McKenzie, Debbie, Sim, Valerie L.
Publicado 2021

A novel mechanism of phenotypic heterogeneity in Creutzfeldt-Jakob disease

por Nemani, Satish K., Xiao, Xiangzhu, Cali, Ignazio, Cracco, Laura, Puoti, Gianfranco, Nigro, Massimiliano, Lavrich, Jody, Bharara Singh, Anuradha, Appleby, Brian S., Sim, Valerie L., Notari, Silvio, Surewicz, Witold K., Gambetti, Pierluigi
Publicado 2020

TREM2 expression in the brain and biological fluids in prion diseases

por Diaz-Lucena, Daniela, Kruse, Niels, Thüne, Katrin, Schmitz, Matthias, Villar-Piqué, Anna, da Cunha, Jose Eriton Gomes, Hermann, Peter, López-Pérez, Óscar, Andrés-Benito, Pol, Ladogana, Anna, Calero, Miguel, Vidal, Enric, Riggert, Joachim, Pineau, Hailey, Sim, Valerie, Zetterberg, Henrik, Blennow, Kaj, del Río, Jose Antonio, Marín-Moreno, Alba, Espinosa, Juan Carlos, Torres, Juan María, Sánchez-Valle, Raquel, Mollenhauer, Brit, Ferrer, Isidre, Zerr, Inga, Llorens, Franc
Publicado 2021