Transient up-regulation of miR-155-3p by lipopolysaccharide in primary human monocyte-derived macrophages results in RISC incorporation but does not alter TNF expression

por Simmonds, Rachel E.
Publicado 2019

Mechanistic insights into the inhibition of Sec61-dependent co- and post-translational translocation by mycolactone

por McKenna, Michael, Simmonds, Rachel E., High, Stephen
Publicado 2016

Mycolactone reveals the substrate-driven complexity of Sec61-dependent transmembrane protein biogenesis

por McKenna, Michael, Simmonds, Rachel E., High, Stephen
Publicado 2017

Editorial: Host-pathogen interactions in nontuberculous mycobacterial infections

por Lorè, Nicola Ivan, Yamasaki, Sho, Simmonds, Rachel E., Jo, Eun-Kyeong
Publicado 2023

Recent advances: role of mycolactone in the pathogenesis and monitoring of Mycobacterium ulcerans infection/Buruli ulcer disease

por Sarfo, Fred Stephen, Phillips, Richard, Wansbrough‐Jones, Mark, Simmonds, Rachel E.
Publicado 2015

The One That Got Away: How Macrophage-Derived IL-1β Escapes the Mycolactone-Dependent Sec61 Blockade in Buruli Ulcer

por Hall, Belinda S., Hsieh, Louise Tzung-Harn, Sacre, Sandra, Simmonds, Rachel E.
Publicado 2022

The Pathogenic Mechanism of the Mycobacterium ulcerans Virulence Factor, Mycolactone, Depends on Blockade of Protein Translocation into the ER

por Hall, Belinda S., Hill, Kirsti, McKenna, Michael, Ogbechi, Joy, High, Stephen, Willis, Anne E., Simmonds, Rachel E.
Publicado 2014

Inhibition of Sec61-dependent translocation by mycolactone uncouples the integrated stress response from ER stress, driving cytotoxicity via translational activation of ATF4

por Ogbechi, Joy, Hall, Belinda S., Sbarrato, Thomas, Taunton, Jack, Willis, Anne E., Wek, Ronald C., Simmonds, Rachel E.
Publicado 2018

Buruli Ulcer: a Review of the Current Knowledge

por Yotsu, Rie R., Suzuki, Koichi, Simmonds, Rachel E., Bedimo, Roger, Ablordey, Anthony, Yeboah-Manu, Dorothy, Phillips, Richard, Asiedu, Kingsley
Publicado 2018

Inhibition of the SEC61 translocon by mycolactone induces a protective autophagic response controlled by EIF2S1-dependent translation that does not require ULK1 activity

por Hall, Belinda S, Dos Santos, Scott J, Hsieh, Louise Tzung-Harn, Manifava, Maria, Ruf, Marie-Thérèse, Pluschke, Gerd, Ktistakis, Nicholas, Simmonds, Rachel E
Publicado 2021

Mycolactone enhances the Ca(2+) leak from endoplasmic reticulum by trapping Sec61 translocons in a Ca(2+) permeable state

por Bhadra, Pratiti, Dos Santos, Scott, Gamayun, Igor, Pick, Tillman, Neumann, Clarissa, Ogbechi, Joy, Hall, Belinda S., Zimmermann, Richard, Helms, Volkhard, Simmonds, Rachel E., Cavalié, Adolfo
Publicado 2021

Mycolactone causes catastrophic Sec61-dependent loss of the endothelial glycocalyx and basement membrane: a new indirect mechanism driving tissue necrosis in Mycobacterium ulcerans...

por Hsieh, Louise Tzung-Harn, Hall, Belinda S., Newcombe, Jane, Mendum, Tom A., Umrania, Yagnesh, Deery, Michael J., Shi, Wei Q., Salguero, Francisco J., Simmonds, Rachel E
Publicado 2023

Mycolactone-Dependent Depletion of Endothelial Cell Thrombomodulin Is Strongly Associated with Fibrin Deposition in Buruli Ulcer Lesions

por Ogbechi, Joy, Ruf, Marie-Thérèse, Hall, Belinda S., Bodman-Smith, Katherine, Vogel, Moritz, Wu, Hua-Lin, Stainer, Alexander, Esmon, Charles T., Ahnström, Josefin, Pluschke, Gerd, Simmonds, Rachel E.
Publicado 2015

Aberrant stromal tissue factor localisation and mycolactone-driven vascular dysfunction, exacerbated by IL-1β, are linked to fibrin formation in Buruli ulcer lesions

por Hsieh, Louise Tzung-Harn, Dos Santos, Scott J., Hall, Belinda S., Ogbechi, Joy, Loglo, Aloysius D., Salguero, Francisco Javier, Ruf, Marie-Thérèse, Pluschke, Gerd, Simmonds, Rachel E.
Publicado 2022

Structure of the Inhibited State of the Sec Translocon

por Gérard, Samuel F., Hall, Belinda S., Zaki, Afroditi M., Corfield, Katherine A., Mayerhofer, Peter U., Costa, Catia, Whelligan, Daniel K., Biggin, Philip C., Simmonds, Rachel E., Higgins, Matthew K.
Publicado 2020

Synthesis, Biological Evaluation and Docking Studies of Ring-Opened Analogues of Ipomoeassin F

por O’Keefe, Sarah, Bhadra, Pratiti, Duah, Kwabena B., Zong, Guanghui, Tenay, Levise, Andrews, Lauren, Schneider, Hayden, Anderson, Ashley, Hu, Zhijian, Aljewari, Hazim S., Hall, Belinda S., Simmonds, Rachel E., Helms, Volkhard, High, Stephen, Shi, Wei Q.
Publicado 2022