Modulating Neurotrophin Receptor Signaling as a Therapeutic Strategy for Huntington’s Disease

por Simmons, Danielle A.
Publicado 2017

A Small Molecule p75(NTR) Ligand, LM11A-31, Reverses Cholinergic Neurite Dystrophy in Alzheimer's Disease Mouse Models with Mid- to Late-Stage Disease Progression

por Simmons, Danielle A., Knowles, Juliet K., Belichenko, Nadia P., Banerjee, Gargi, Finkle, Carly, Massa, Stephen M., Longo, Frank M.
Publicado 2014

TSPO–PET imaging using [(18)F]PBR06 is a potential translatable biomarker for treatment response in Huntington’s disease: preclinical evidence with the p75(NTR) ligand LM11A-31

por Simmons, Danielle A, James, Michelle L, Belichenko, Nadia P, Semaan, Sarah, Condon, Christina, Kuan, Jason, Shuhendler, Adam J, Miao, Zheng, Chin, Frederick T, Longo, Frank M
Publicado 2018

A small molecule p75(NTR) ligand normalizes signalling and reduces Huntington’s disease phenotypes in R6/2 and BACHD mice

por Simmons, Danielle A., Belichenko, Nadia P., Ford, Ellen C., Semaan, Sarah, Monbureau, Marie, Aiyaswamy, Sruti, Holman, Cameron M., Condon, Christina, Shamloo, Mehrdad, Massa, Stephen M., Longo, Frank M.
Publicado 2016

Neuroimaging, Urinary, and Plasma Biomarkers of Treatment Response in Huntington’s Disease: Preclinical Evidence with the p75(NTR) Ligand LM11A-31

por Simmons, Danielle A., Mills, Brian D., Butler III, Robert R., Kuan, Jason, McHugh, Tyne L. M., Akers, Carolyn, Zhou, James, Syriani, Wassim, Grouban, Maged, Zeineh, Michael, Longo, Frank M.
Publicado 2021

A small molecule p75(NTR) ligand prevents cognitive deficits and neurite degeneration in an Alzheimer’s mouse model

por Knowles, Juliet K., Simmons, Danielle A., Nguyen, Thuy-Vi V., Vander Griend, Lilith, Xie, Youmei, Zhang, Hong, Yang, Tao, Pollak, Julia, Chang, Timothy, Arancio, Ottavio, Buckwalter, Marion S., Wyss-Coray, Tony, Massa, Stephen M., Longo, Frank M.
Publicado 2013