Human pluripotent stem cell (hPSC) and organoid models of autism: opportunities and limitations

por Kilpatrick, Savannah, Irwin, Courtney, Singh, Karun K.
Publicado 2023

Emerging proteomic approaches to identify the underlying pathophysiology of neurodevelopmental and neurodegenerative disorders

por Murtaza, Nadeem, Uy, Jarryll, Singh, Karun K.
Publicado 2020

Neuregulin-1 Regulates Cortical Inhibitory Neuron Dendrite and Synapse Growth through DISC1

por Unda, Brianna K., Kwan, Vickie, Singh, Karun K.
Publicado 2016

Wnt signaling networks in autism spectrum disorder and intellectual disability

por Kwan, Vickie, Unda, Brianna K., Singh, Karun K.
Publicado 2016

A mini-review: Bridging the gap between autism spectrum disorder and pain comorbidities

por Brown, Chad O., Uy, Jarryll, Singh, Karun K.
Publicado 2020

Origin of Sex-Biased Mental Disorders: An Evolutionary Perspective

por Singh, Rama S., Singh, Karun K., Singh, Shiva M.
Publicado 2021

Ankyrin-G Regulates Neurogenesis and Wnt Signaling by Altering the Subcellular Localization of β-catenin

por Durak, Omer, de Anda, Froylan Calderon, Singh, Karun K., Leussis, Melanie P., Petryshen, Tracey L., Sklar, Pamela, Tsai, Li-Huei
Publicado 2014

TAOK2 rescues autism-linked developmental deficits in a 16p11.2 microdeletion mouse model

por Scharrenberg, Robin, Richter, Melanie, Johanns, Ole, Meka, Durga Praveen, Rücker, Tabitha, Murtaza, Nadeem, Lindenmaier, Zsuzsa, Ellegood, Jacob, Naumann, Anne, Zhao, Bing, Schwanke, Birgit, Sedlacik, Jan, Fiehler, Jens, Hanganu-Opatz, Ileana L., Lerch, Jason P., Singh, Karun K., de Anda, Froylan Calderon
Publicado 2022

CNTN5(-)(/+)or EHMT2(-)(/+)human iPSC-derived neurons from individuals with autism develop hyperactive neuronal networks

por Deneault, Eric, Faheem, Muhammad, White, Sean H, Rodrigues, Deivid C, Sun, Song, Wei, Wei, Piekna, Alina, Thompson, Tadeo, Howe, Jennifer L, Chalil, Leon, Kwan, Vickie, Walker, Susan, Pasceri, Peter, Roth, Frederick P, Yuen, Ryan KC, Singh, Karun K, Ellis, James, Scherer, Stephen W
Publicado 2019

Impaired OTUD7A-dependent Ankyrin regulation mediates neuronal dysfunction in mouse and human models of the 15q13.3 microdeletion syndrome

por Unda, Brianna K., Chalil, Leon, Yoon, Sehyoun, Kilpatrick, Savannah, Irwin, Courtney, Xing, Sansi, Murtaza, Nadeem, Cheng, Anran, Brown, Chad, Afonso, Alexandria, McCready, Elizabeth, Ronen, Gabriel M., Howe, Jennifer, Caye-Eude, Aurélie, Verloes, Alain, Doble, Brad W., Faivre, Laurence, Vitobello, Antonio, Scherer, Stephen W., Lu, Yu, Penzes, Peter, Singh, Karun K.
Publicado 2023

Complete Disruption of Autism-Susceptibility Genes by Gene Editing Predominantly Reduces Functional Connectivity of Isogenic Human Neurons

por Deneault, Eric, White, Sean H., Rodrigues, Deivid C., Ross, P. Joel, Faheem, Muhammad, Zaslavsky, Kirill, Wang, Zhuozhi, Alexandrova, Roumiana, Pellecchia, Giovanna, Wei, Wei, Piekna, Alina, Kaur, Gaganjot, Howe, Jennifer L., Kwan, Vickie, Thiruvahindrapuram, Bhooma, Walker, Susan, Lionel, Anath C., Pasceri, Peter, Merico, Daniele, Yuen, Ryan K.C., Singh, Karun K., Ellis, James, Scherer, Stephen W.
Publicado 2018

Complete Disruption of Autism-Susceptibility Genes by Gene Editing Predominantly Reduces Functional Connectivity of Isogenic Human Neurons

por Deneault, Eric, White, Sean H., Rodrigues, Deivid C., Ross, P. Joel, Faheem, Muhammad, Zaslavsky, Kirill, Wang, Zhuozhi, Alexandrova, Roumiana, Pellecchia, Giovanna, Wei, Wei, Piekna, Alina, Kaur, Gaganjot, Howe, Jennifer L., Kwan, Vickie, Thiruvahindrapuram, Bhooma, Walker, Susan, Lionel, Anath C., Pasceri, Peter, Merico, Daniele, Yuen, Ryan K.C., Singh, Karun K., Ellis, James, Scherer, Stephen W.
Publicado 2019

OTUD7A Regulates Neurodevelopmental Phenotypes in the 15q13.3 Microdeletion Syndrome

por Uddin, Mohammed, Unda, Brianna K., Kwan, Vickie, Holzapfel, Nicholas T., White, Sean H., Chalil, Leon, Woodbury-Smith, Marc, Ho, Karen S., Harward, Erin, Murtaza, Nadeem, Dave, Biren, Pellecchia, Giovanna, D’Abate, Lia, Nalpathamkalam, Thomas, Lamoureux, Sylvia, Wei, John, Speevak, Marsha, Stavropoulos, James, Hope, Kristin J., Doble, Brad W., Nielsen, Jacob, Wassman, E. Robert, Scherer, Stephen W., Singh, Karun K.
Publicado 2018

Altered TAOK2 activity causes autism-related neurodevelopmental and cognitive abnormalities through RhoA signaling

por Richter, Melanie, Murtaza, Nadeem, Scharrenberg, Robin, White, Sean H., Johanns, Ole, Walker, Susan, Yuen, Ryan K. C., Schwanke, Birgit, Bedürftig, Bianca, Henis, Melad, Scharf, Sarah, Kraus, Vanessa, Dörk, Ronja, Hellmann, Jakob, Lindenmaier, Zsuzsa, Ellegood, Jacob, Hartung, Henrike, Kwan, Vickie, Sedlacik, Jan, Fiehler, Jens, Schweizer, Michaela, Lerch, Jason P., Hanganu-Opatz, Ileana L., Morellini, Fabio, Scherer, Stephen W., Singh, Karun K., Calderon de Anda, Froylan
Publicado 2018

Regulation of autism-relevant behaviors by cerebellar–prefrontal cortical circuits

por Kelly, Elyza, Meng, Fantao, Fujita, Hirofumi, Morgado, Felipe, Kazemi, Yasaman, Rice, Laura C., Ren, Chongyu, Escamilla, Christine Ochoa, Gibson, Jennifer M., Sajadi, Sanaz, Pendry, Robert J., Tan, Tommy, Ellegood, Jacob, Basson, M. Albert, Blakely, Randy D., Dindot, Scott V., Golzio, Christelle, Hahn, Maureen K., Katsanis, Nicholas, Robins, Diane M., Silverman, Jill L., Singh, Karun K., Wevrick, Rachel, Taylor, Margot J., Hammill, Christopher, Anagnostou, Evdokia, Pfeiffer, Brad E., Stoodley, Catherine J., Lerch, Jason P., du Lac, Sascha, Tsai, Peter T.
Publicado 2020