GWAS of three molecular traits highlights core genes and pathways alongside a highly polygenic background

por Sinnott-Armstrong, Nasa, Naqvi, Sahin, Rivas, Manuel, Pritchard, Jonathan K
Publicado 2021

Graphical analysis for phenome-wide causal discovery in genotyped population-scale biobanks

por Amar, David, Sinnott-Armstrong, Nasa, Ashley, Euan A., Rivas, Manuel A.
Publicado 2021

Portability of Polygenic Risk Scores for Sleep Duration, Insomnia and Chronotype in 33,493 Individuals

por Perkiö, Anna, Merikanto, Ilona, Kantojärvi, Katri, Paunio, Tiina, Sinnott-Armstrong, Nasa, Jones, Samuel E., Ollila, Hanna M.
Publicado 2022

High-resolution genome-wide functional dissection of transcriptional regulatory regions and nucleotides in human

por Wang, Xinchen, He, Liang, Goggin, Sarah M., Saadat, Alham, Wang, Li, Sinnott-Armstrong, Nasa, Claussnitzer, Melina, Kellis, Manolis
Publicado 2018

Homogeneity in the association of body mass index with type 2 diabetes across the UK Biobank: A Mendelian randomization study

por Wainberg, Michael, Mahajan, Anubha, Kundaje, Anshul, McCarthy, Mark I., Ingelsson, Erik, Sinnott-Armstrong, Nasa, Rivas, Manuel A.
Publicado 2019

Integrative analysis of metabolite GWAS illuminates the molecular basis of pleiotropy and genetic correlation

por Smith, Courtney J, Sinnott-Armstrong, Nasa, Cichońska, Anna, Julkunen, Heli, Fauman, Eric B, Würtz, Peter, Pritchard, Jonathan K
Publicado 2022

A comprehensive rRNA variation atlas in health and disease

por Rothschild, Daphna, Susanto, Teodorus Theo, Spence, Jeffrey P., Genuth, Naomi R., Sinnott-Armstrong, Nasa, Pritchard, Jonathan K., Barna, Maria
Publicado 2023

A lead candidate functional single nucleotide polymorphism within the WARS2 gene associated with waist-hip-ratio does not alter RNA stability

por Mušo, Milan, Dumbell, Rebecca, Pulit, Sara, Sinnott-Armstrong, Nasa, Laber, Samantha, Zolkiewski, Louisa, Bentley, Liz, Claussnitzer, Melina, Cox, Roger D.
Publicado 2020

Reduced signal for polygenic adaptation of height in UK Biobank

por Berg, Jeremy J, Harpak, Arbel, Sinnott-Armstrong, Nasa, Joergensen, Anja Moltke, Mostafavi, Hakhamanesh, Field, Yair, Boyle, Evan August, Zhang, Xinjun, Racimo, Fernando, Pritchard, Jonathan K, Coop, Graham
Publicado 2019

Performance of Nucleic Acid Amplification Tests for Detection of Severe Acute Respiratory Syndrome Coronavirus 2 in Prospectively Pooled Specimens

por Wang, Hannah, Hogan, Catherine A., Miller, Jacob A., Sahoo, Malaya K., Huang, ChunHong, Mfuh, Kenji O., Sibai, Mamdouh, Zehnder, James, Hickey, Brendan, Sinnott-Armstrong, Nasa, Pinsky, Benjamin A.
Publicado 2021

A conserved YAP/Notch/REST network controls the neuroendocrine cell fate in the lungs

por Shue, Yan Ting, Drainas, Alexandros P., Li, Nancy Yanzhe, Pearsall, Sarah M., Morgan, Derrick, Sinnott-Armstrong, Nasa, Hipkins, Susan Q., Coles, Garry L., Lim, Jing Shan, Oro, Anthony E., Simpson, Kathryn L., Dive, Caroline, Sage, Julien
Publicado 2022

Landscape of cohesin-mediated chromatin loops in the human genome

por Grubert, Fabian, Srivas, Rohith, Spacek, Damek  V, Kasowski, Maya, Ruiz-Velasco, Mariana, Sinnott-Armstrong, Nasa, Greenside, Peyton, Narasimha, Anil, Liu, Qing, Geller, Benjamin, Sanghi, Akshay, Kulik, Michael, Sa, Silin, Rabinovitch, Marlene, Kundaje, Anshul, Dalton, Stephen, Zaugg, Judith B., Snyder, Michael
Publicado 2020

A regulatory variant at 3q21.1 confers an increased pleiotropic risk for hyperglycemia and altered bone mineral density

por Sinnott-Armstrong, Nasa, Sousa, Isabel S., Laber, Samantha, Rendina-Ruedy, Elizabeth, Nitter Dankel, Simon E., Ferreira, Teresa, Mellgren, Gunnar, Karasik, David, Rivas, Manuel, Pritchard, Jonathan, Guntur, Anyonya R., Cox, Roger D., Lindgren, Cecilia M., Hauner, Hans, Sallari, Richard, Rosen, Clifford J., Hsu, Yi-Hsiang, Lander, Eric S., Kiel, Douglas P., Claussnitzer, Melina
Publicado 2021

Multi-faceted epigenetic dysregulation of gene expression promotes esophageal squamous cell carcinoma

por Cao, Wei, Lee, Hayan, Wu, Wei, Zaman, Aubhishek, McCorkle, Sean, Yan, Ming, Chen, Justin, Xing, Qinghe, Sinnott-Armstrong, Nasa, Xu, Hongen, Sailani, M. Reza, Tang, Wenxue, Cui, Yuanbo, liu, Jia, Guan, Hongyan, Lv, Pengju, Sun, Xiaoyan, Sun, Lei, Han, Pengli, Lou, Yanan, Chang, Jing, Wang, Jinwu, Gao, Yuchi, Guo, Jiancheng, Schenk, Gundolf, Shain, Alan Hunter, Biddle, Fred G., Collisson, Eric, Snyder, Michael, Bivona, Trever G.
Publicado 2020

Discovering cellular programs of intrinsic and extrinsic drivers of metabolic traits using LipocyteProfiler

por Laber, Samantha, Strobel, Sophie, Mercader, Josep M., Dashti, Hesam, dos Santos, Felipe R.C., Kubitz, Phil, Jackson, Maya, Ainbinder, Alina, Honecker, Julius, Agrawal, Saaket, Garborcauskas, Garrett, Stirling, David R., Leong, Aaron, Figueroa, Katherine, Sinnott-Armstrong, Nasa, Kost-Alimova, Maria, Deodato, Giacomo, Harney, Alycen, Way, Gregory P., Saadat, Alham, Harken, Sierra, Reibe-Pal, Saskia, Ebert, Hannah, Zhang, Yixin, Calabuig-Navarro, Virtu, McGonagle, Elizabeth, Stefek, Adam, Dupuis, Josée, Cimini, Beth A., Hauner, Hans, Udler, Miriam S., Carpenter, Anne E., Florez, Jose C., Lindgren, Cecilia, Jacobs, Suzanne B.R., Claussnitzer, Melina
Publicado 2023

Narcolepsy risk loci outline role of T cell autoimmunity and infectious triggers in narcolepsy

por Ollila, Hanna M., Sharon, Eilon, Lin, Ling, Sinnott-Armstrong, Nasa, Ambati, Aditya, Yogeshwar, Selina M., Hillary, Ryan P., Jolanki, Otto, Faraco, Juliette, Einen, Mali, Luo, Guo, Zhang, Jing, Han, Fang, Yan, Han, Dong, Xiao Song, Li, Jing, Zhang, Jun, Hong, Seung-Chul, Kim, Tae Won, Dauvilliers, Yves, Barateau, Lucie, Lammers, Gert Jan, Fronczek, Rolf, Mayer, Geert, Santamaria, Joan, Arnulf, Isabelle, Knudsen-Heier, Stine, Bredahl, May Kristin Lyamouri, Thorsby, Per Medbøe, Plazzi, Giuseppe, Pizza, Fabio, Moresco, Monica, Crowe, Catherine, Van den Eeden, Stephen K., Lecendreux, Michel, Bourgin, Patrice, Kanbayashi, Takashi, Martínez-Orozco, Francisco J., Peraita-Adrados, Rosa, Benetó, Antonio, Montplaisir, Jacques, Desautels, Alex, Huang, Yu-Shu, Jennum, Poul, Nevsimalova, Sona, Kemlink, David, Iranzo, Alex, Overeem, Sebastiaan, Wierzbicka, Aleksandra, Geisler, Peter, Sonka, Karel, Honda, Makoto, Högl, Birgit, Stefani, Ambra, Coelho, Fernando Morgadinho, Mantovani, Vilma, Feketeova, Eva, Wadelius, Mia, Eriksson, Niclas, Smedje, Hans, Hallberg, Pär, Hesla, Per Egil, Rye, David, Pelin, Zerrin, Ferini-Strambi, Luigi, Bassetti, Claudio L., Mathis, Johannes, Khatami, Ramin, Aran, Adi, Nampoothiri, Sheela, Olsson, Tomas, Kockum, Ingrid, Partinen, Markku, Perola, Markus, Kornum, Birgitte R., Rueger, Sina, Winkelmann, Juliane, Miyagawa, Taku, Toyoda, Hiromi, Khor, Seik-Soon, Shimada, Mihoko, Tokunaga, Katsushi, Rivas, Manuel, Pritchard, Jonathan K., Risch, Neil, Kutalik, Zoltan, O’Hara, Ruth, Hallmayer, Joachim, Ye, Chun Jimmie, Mignot, Emmanuel J.
Publicado 2023

Analyses of non-coding somatic drivers in 2,658 cancer whole genomes

por Rheinbay, Esther, Nielsen, Morten Muhlig, Abascal, Federico, Wala, Jeremiah A., Shapira, Ofer, Tiao, Grace, Hornshøj, Henrik, Hess, Julian M., Juul, Randi Istrup, Lin, Ziao, Feuerbach, Lars, Sabarinathan, Radhakrishnan, Madsen, Tobias, Kim, Jaegil, Mularoni, Loris, Shuai, Shimin, Lanzós, Andrés, Herrmann, Carl, Maruvka, Yosef E., Shen, Ciyue, Amin, Samirkumar B., Bandopadhayay, Pratiti, Bertl, Johanna, Boroevich, Keith A., Busanovich, John, Carlevaro-Fita, Joana, Chakravarty, Dimple, Chan, Calvin Wing Yiu, Craft, David, Dhingra, Priyanka, Diamanti, Klev, Fonseca, Nuno A., Gonzalez-Perez, Abel, Guo, Qianyun, Hamilton, Mark P., Haradhvala, Nicholas J., Hong, Chen, Isaev, Keren, Johnson, Todd A., Juul, Malene, Kahles, Andre, Kahraman, Abdullah, Kim, Youngwook, Komorowski, Jan, Kumar, Kiran, Kumar, Sushant, Lee, Donghoon, Lehmann, Kjong-Van, Li, Yilong, Liu, Eric Minwei, Lochovsky, Lucas, Park, Keunchil, Pich, Oriol, Roberts, Nicola D., Saksena, Gordon, Schumacher, Steven E., Sidiropoulos, Nikos, Sieverling, Lina, Sinnott-Armstrong, Nasa, Stewart, Chip, Tamborero, David, Tubio, Jose M. C., Umer, Husen M., Uusküla-Reimand, Liis, Wadelius, Claes, Wadi, Lina, Yao, Xiaotong, Zhang, Cheng-Zhong, Zhang, Jing, Haber, James E., Hobolth, Asger, Imielinski, Marcin, Kellis, Manolis, Lawrence, Michael S., von Mering, Christian, Nakagawa, Hidewaki, Raphael, Benjamin J., Rubin, Mark A., Sander, Chris, Stein, Lincoln D., Stuart, Joshua M., Tsunoda, Tatsuhiko, Wheeler, David A., Johnson, Rory, Reimand, Jüri, Gerstein, Mark, Khurana, Ekta, Campbell, Peter J., López-Bigas, Núria, Weischenfeldt, Joachim, Beroukhim, Rameen, Martincorena, Iñigo, Pedersen, Jakob Skou, Getz, Gad
Publicado 2020

Author Correction: Analyses of non-coding somatic drivers in 2,658 cancer whole genomes

por Rheinbay, Esther, Nielsen, Morten Muhlig, Abascal, Federico, Wala, Jeremiah A., Shapira, Ofer, Tiao, Grace, Hornshøj, Henrik, Hess, Julian M., Juul, Randi Istrup, Lin, Ziao, Feuerbach, Lars, Sabarinathan, Radhakrishnan, Madsen, Tobias, Kim, Jaegil, Mularoni, Loris, Shuai, Shimin, Lanzós, Andrés, Herrmann, Carl, Maruvka, Yosef E., Shen, Ciyue, Amin, Samirkumar B., Bandopadhayay, Pratiti, Bertl, Johanna, Boroevich, Keith A., Busanovich, John, Carlevaro-Fita, Joana, Chakravarty, Dimple, Chan, Calvin Wing Yiu, Craft, David, Dhingra, Priyanka, Diamanti, Klev, Fonseca, Nuno A., Gonzalez-Perez, Abel, Guo, Qianyun, Hamilton, Mark P., Haradhvala, Nicholas J., Hong, Chen, Isaev, Keren, Johnson, Todd A., Juul, Malene, Kahles, Andre, Kahraman, Abdullah, Kim, Youngwook, Komorowski, Jan, Kumar, Kiran, Kumar, Sushant, Lee, Donghoon, Lehmann, Kjong-Van, Li, Yilong, Liu, Eric Minwei, Lochovsky, Lucas, Park, Keunchil, Pich, Oriol, Roberts, Nicola D., Saksena, Gordon, Schumacher, Steven E., Sidiropoulos, Nikos, Sieverling, Lina, Sinnott-Armstrong, Nasa, Stewart, Chip, Tamborero, David, Tubio, Jose M. C., Umer, Husen M., Uusküla-Reimand, Liis, Wadelius, Claes, Wadi, Lina, Yao, Xiaotong, Zhang, Cheng-Zhong, Zhang, Jing, Haber, James E., Hobolth, Asger, Imielinski, Marcin, Kellis, Manolis, Lawrence, Michael S., von Mering, Christian, Nakagawa, Hidewaki, Raphael, Benjamin J., Rubin, Mark A., Sander, Chris, Stein, Lincoln D., Stuart, Joshua M., Tsunoda, Tatsuhiko, Wheeler, David A., Johnson, Rory, Reimand, Jüri, Gerstein, Mark, Khurana, Ekta, Campbell, Peter J., López-Bigas, Núria, Weischenfeldt, Joachim, Beroukhim, Rameen, Martincorena, Iñigo, Pedersen, Jakob Skou, Getz, Gad
Publicado 2023

Discovery of common and rare genetic risk variants for colorectal cancer

por Huyghe, Jeroen R, Bien, Stephanie A, Harrison, Tabitha A, Kang, Hyun Min, Chen, Sai, Schmit, Stephanie L, Conti, David V, Qu, Conghui, Jeon, Jihyoun, Edlund, Christopher K, Greenside, Peyton, Wainberg, Michael, Schumacher, Fredrick R, Smith, Joshua D, Levine, David M, Nelson, Sarah C, Sinnott-Armstrong, Nasa A, Albanes, Demetrius, Alonso, M Henar, Anderson, Kristin, Arnau-Collell, Coral, Arndt, Volker, Bamia, Christina, Banbury, Barbara L, Baron, John A, Berndt, Sonja I, Bézieau, Stéphane, Bishop, D Timothy, Boehm, Juergen, Boeing, Heiner, Brenner, Hermann, Brezina, Stefanie, Buch, Stephan, Buchanan, Daniel D, Burnett-Hartman, Andrea, Butterbach, Katja, Caan, Bette J, Campbell, Peter T, Carlson, Christopher S, Castellví-Bel, Sergi, Chan, Andrew T, Chang-Claude, Jenny, Chanock, Stephen J, Chirlaque, Maria-Dolores, Cho, Sang Hee, Connolly, Charles M, Cross, Amanda J, Cuk, Katarina, Curtis, Keith R, de la Chapelle, Albert, Doheny, Kimberly F, Duggan, David, Easton, Douglas F, Elias, Sjoerd G, Elliott, Faye, English, Dallas R, Feskens, Edith JM, Figueiredo, Jane C, Fischer, Rocky, FitzGerald, Liesel M, Forman, David, Gala, Manish, Gallinger, Steven, Gauderman, W James, Giles, Graham G, Gillanders, Elizabeth, Gong, Jian, Goodman, Phyllis J, Grady, William M, Grove, John S, Gsur, Andrea, Gunter, Marc J, Haile, Robert W, Hampe, Jochen, Hampel, Heather, Harlid, Sophia, Hayes, Richard B, Hofer, Philipp, Hoffmeister, Michael, Hopper, John L, Hsu, Wan-Ling, Huang, Wen-Yi, Hudson, Thomas J, Hunter, David J, Ibañez-Sanz, Gemma, Idos, Gregory E, Ingersoll, Roxann, Jackson, Rebecca D, Jacobs, Eric J, Jenkins, Mark A, Joshi, Amit D, Joshu, Corinne E, Keku, Temitope O, Key, Timothy J, Kim, Hyeong Rok, Kobayashi, Emiko, Kolonel, Laurence N, Kooperberg, Charles, Kühn, Tilman, Küry, Sébastien, Kweon, Sun-Seog, Larsson, Susanna C, Laurie, Cecelia A, Le Marchand, Loic, Leal, Suzanne M, Lee, Soo Chin, Lejbkowicz, Flavio, Lemire, Mathieu, Li, Christopher I, Li, Li, Lieb, Wolfgang, Lin, Yi, Lindblom, Annika, Lindor, Noralane M, Ling, Hua, Louie, Tin L, Männistö, Satu, Markowitz, Sanford D, Martín, Vicente, Masala, Giovanna, McNeil, Caroline E, Melas, Marilena, Milne, Roger L, Moreno, Lorena, Murphy, Neil, Myte, Robin, Naccarati, Alessio, Newcomb, Polly A, Offit, Kenneth, Ogino, Shuji, Onland-Moret, N Charlotte, Pardini, Barbara, Parfrey, Patrick S, Pearlman, Rachel, Perduca, Vittorio, Pharoah, Paul D P, Pinchev, Mila, Platz, Elizabeth A, Prentice, Ross L, Pugh, Elizabeth, Raskin, Leon, Rennert, Gad, Rennert, Hedy S, Riboli, Elio, Rodríguez-Barranco, Miguel, Romm, Jane, Sakoda, Lori C, Schafmayer, Clemens, Schoen, Robert E, Seminara, Daniela, Shah, Mitul, Shelford, Tameka, Shin, Min-Ho, Shulman, Katerina, Sieri, Sabina, Slattery, Martha L, Southey, Melissa C, Stadler, Zsofia K, Stegmaier, Christa, Su, Yu-Ru, Tangen, Catherine M, Thibodeau, Stephen N, Thomas, Duncan C, Thomas, Sushma S, Toland, Amanda E, Trichopoulou, Antonia, Ulrich, Cornelia M, Van Den Berg, David J, van Duijnhoven, Franzel JB, Van Guelpen, Bethany, van Kranen, Henk, Vijai, Joseph, Visvanathan, Kala, Vodicka, Pavel, Vodickova, Ludmila, Vymetalkova, Veronika, Weigl, Korbinian, Weinstein, Stephanie J, White, Emily, Win, Aung Ko, Wolf, C Roland, Wolk, Alicja, Woods, Michael O, Wu, Anna H, Zaidi, Syed H, Zanke, Brent W, Zhang, Qing, Zheng, Wei, Scacheri, Peter C, Potter, John D, Bassik, Michael C, Kundaje, Anshul, Casey, Graham, Moreno, Victor, Abecasis, Goncalo R, Nickerson, Deborah A, Gruber, Stephen B, Hsu, Li, Peters, Ulrike
Publicado 2018