The potential of rapalogs to enhance resilience against SARS-CoV-2 infection and reduce the severity of COVID-19

por Bischof, Evelyne, Siow, Richard C, Zhavoronkov, Alex, Kaeberlein, Matt
Publicado 2021

Perturbations of the anti-ageing hormone Klotho in patients with type 1 diabetes and microalbuminuria

por Maltese, Giuseppe, Fountoulakis, Nikolaos, Siow, Richard C., Gnudi, Luigi, Karalliedde, Janaka
Publicado 2017

A PP2A-mediated feedback mechanism controls Ca(2+)-dependent NO synthesis under physiological oxygen

por Keeley, Thomas P., Siow, Richard C. M., Jacob, Ron, Mann, Giovanni E.
Publicado 2017

Reduced SERCA activity underlies dysregulation of Ca(2+) homeostasis under atmospheric O(2) levels

por Keeley, Thomas P., Siow, Richard C. M., Jacob, Ron, Mann, Giovanni E.
Publicado 2018

Reduced Levels of the Antiaging Hormone Klotho are Associated With Increased Aortic Stiffness in Diabetic Kidney Disease

por Fountoulakis, Nikolaos, Psefteli, Paraskevi-Maria, Maltese, Giuseppe, Gnudi, Luigi, Siow, Richard C., Karalliedde, Janaka
Publicado 2023

Cardioprotective effects of Cu((II))ATSM in human vascular smooth muscle cells and cardiomyocytes mediated by Nrf2 and DJ-1

por Srivastava, Salil, Blower, Philip J., Aubdool, Aisah A., Hider, Robert C., Mann, Giovanni E., Siow, Richard C.
Publicado 2016

The anti‐ageing hormone klotho induces Nrf2‐mediated antioxidant defences in human aortic smooth muscle cells

por Maltese, Giuseppe, Psefteli, Paraskevi‐Maria, Rizzo, Benedetta, Srivastava, Salil, Gnudi, Luigi, Mann, Giovanni E., Siow, Richard C.M.
Publicado 2016

Nrf2-regulated redox signaling in brain endothelial cells adapted to physiological oxygen levels: Consequences for sulforaphane mediated protection against hypoxia-reoxygenation

por Warpsinski, Gabriela, Smith, Matthew J., Srivastava, Salil, Keeley, Thomas P., Siow, Richard C.M., Fraser, Paul A., Mann, Giovanni E.
Publicado 2020

Glycocalyx sialic acids regulate Nrf2-mediated signaling by fluid shear stress in human endothelial cells

por Psefteli, Paraskevi-Maria, Kitscha, Phoebe, Vizcay, Gema, Fleck, Roland, Chapple, Sarah J., Mann, Giovanni E., Fowler, Mark, Siow, Richard C.
Publicado 2020

Gestational Diabetes Mellitus Impairs Nrf2-Mediated Adaptive Antioxidant Defenses and Redox Signaling in Fetal Endothelial Cells In Utero

por Cheng, Xinghua, Chapple, Sarah J., Patel, Bijal, Puszyk, William, Sugden, David, Yin, Xiaoke, Mayr, Manuel, Siow, Richard C.M., Mann, Giovanni E.
Publicado 2013

Redox and metal profiles in human coronary endothelial and smooth muscle cells under hyperoxia, physiological normoxia and hypoxia: Effects of NRF2 signaling on intracellular zinc

por Smith, Matthew J., Yang, Fan, Griffiths, Alexander, Morrell, Alexander, Chapple, Sarah J., Siow, Richard C.M., Stewart, Theodora, Maret, Wolfgang, Mann, Giovanni E.
Publicado 2023

Vascular protection afforded by zinc supplementation in human coronary artery smooth muscle cells mediated by NRF2 signaling under hypoxia/reoxygenation

por Yang, Fan, Smith, Matthew J., Griffiths, Alexander, Morrell, Alexander, Chapple, Sarah J., Siow, Richard C.M., Stewart, Theodora, Maret, Wolfgang, Mann, Giovanni E.
Publicado 2023

Activation of p38, p21, and NRF-2 Mediates Decreased Proliferation of Human Dental Pulp Stem Cells Cultured under 21% O(2)

por El Alami, Marya, Viña-Almunia, Jose, Gambini, Juan, Mas-Bargues, Cristina, Siow, Richard C.M., Peñarrocha, Miguel, Mann, Giovanni E., Borrás, Consuelo, Viña, Jose
Publicado 2014

Interaction between Maternal and Offspring Diet to Impair Vascular Function and Oxidative Balance in High Fat Fed Male Mice

por Torrens, Christopher, Ethirajan, Priya, Bruce, Kimberley D., Cagampang, Felino R. A., Siow, Richard C. M., Hanson, Mark A., Byrne, Christopher D., Mann, Giovanni E., Clough, Geraldine F.
Publicado 2012

Differential Expression of Insulin-Like Growth Factor 1 and Wnt Family Member 4 Correlates With Functional Heterogeneity of Human Dermal Fibroblasts

por Culley, Oliver J., Louis, Blaise, Philippeos, Christina, Oulès, Bénédicte, Tihy, Matthieu, Segal, Joe M., Hyliands, Della, Jenkins, Gail, Bhogal, Ranjit K., Siow, Richard C., Watt, Fiona M.
Publicado 2021

A Novel α-Calcitonin Gene-Related Peptide Analogue Protects Against End-Organ Damage in Experimental Hypertension, Cardiac Hypertrophy, and Heart Failure

por Aubdool, Aisah A., Thakore, Pratish, Argunhan, Fulye, Smillie, Sarah-Jane, Schnelle, Moritz, Srivastava, Salil, Alawi, Khadija M., Wilde, Elena, Mitchell, Jennifer, Farrell-Dillon, Keith, Richards, Daniel A., Maltese, Giuseppe, Siow, Richard C., Nandi, Manasi, Clark, James E., Shah, Ajay M., Sams, Anette, Brain, Susan D.
Publicado 2017