An Overview of Investigational and Experimental Drug Treatment Strategies for Marfan Syndrome

por Deleeuw, Violette, De Clercq, Adelbert, De Backer, Julie, Sips, Patrick
Publicado 2021

Poly (A)-specific ribonuclease deficiency impacts oogenesis in zebrafish

por Nanjappa, Dechamma Pandyanda, De Saffel, Hanna, Kalladka, Krithika, Arjuna, Srividya, Babu, Nishith, Prasad, Kishan, Sips, Patrick, Chakraborty, Anirban
Publicado 2023

Loss of zebrafish atp6v1e1b, encoding a subunit of vacuolar ATPase, recapitulates human ARCL type 2C syndrome and identifies multiple pathobiological signatures

por Pottie, Lore, Van Gool, Wouter, Vanhooydonck, Michiel, Hanisch, Franz-Georg, Goeminne, Geert, Rajkovic, Andreja, Coucke, Paul, Sips, Patrick, Callewaert, Bert
Publicado 2021

MEK1/2 Inhibition in Murine Heart and Aorta After Oral Administration of Refametinib Supplemented Drinking Water

por Steijns, Felke, Bracke, Nathalie, Renard, Marjolijn, De Backer, Julie, Sips, Patrick, Debunne, Nathan, Wynendaele, Evelien, Verbeke, Frederick, De Spiegeleer, Bart, Campens, Laurence
Publicado 2020

Gender-Specific Modulation of the Response to Arterial Injury by Soluble Guanylate Cyclase α1

por Vermeersch, Pieter, Buys, Emmanuel, Sips, Patrick, Pokreisz, Peter, Marsboom, Glenn, Gillijns, Hilde, Pellens, Marijke, Dewerchin, Mieke, Bloch, Kenneth D, Brouckaert, Peter, Janssens, Stefan
Publicado 2009

Genetic mapping of a modifier locus affecting hypertension in soluble guanylate cyclase α(1) deficient mice

por Buys, Emmanuel S, Raher, Michael J, Kirby, Andrew, Hayton, Sarah R, Tainsh, Laurel T, Sips, Patrick Y, Brouckaert, Peter, Daly, Mark J, Bloch, Kenneth D
Publicado 2011

Ambulatory Electrocardiographic Monitoring and Ectopic Beat Detection in Conscious Mice

por Steijns, Felke, Tóth, Máté I., Demolder, Anthony, Larsen, Lars E., Desloovere, Jana, Renard, Marjolijn, Raedt, Robrecht, Segers, Patrick, De Backer, Julie, Sips, Patrick
Publicado 2020

Spontaneous Right Ventricular Pseudoaneurysms and Increased Arrhythmogenicity in a Mouse Model of Marfan Syndrome

por Steijns, Felke, Renard, Marjolijn, Vanhomwegen, Marine, Vermassen, Petra, Desloovere, Jana, Raedt, Robrecht, Larsen, Lars E., Tóth, Máté I., De Backer, Julie, Sips, Patrick
Publicado 2020

Phenotypes of sGC mutant mice in basic conditions, disease and shock

por Brouckaert, Peter, Cauwels, Anje, Thoonen, Robrecht, Buys, Emmanuel, Bloch, KD, Sips, Patrick, Ichinose, Fumito, Rogge, Elke, Nimmegeers, Sofie, Voorde, Johan Van de, Lefebvre, Romain, Stasch, Johannes-Peter
Publicado 2009

Sensitivity to Sevoflurane anesthesia is decreased in mice with a congenital deletion of Guanylyl Cyclase-1 alpha

por Nagasaka, Yasuko, Wepler, Martin, Thoonen, Robrecht, Sips, Patrick Y., Allen, Kaitlin, Graw, Jan A., Yao, Vincent, Burns, Sara M., Muenster, Stefan, Brouckaert, Peter, Miller, Keith, Solt, Ken, Buys, Emmanuel S., Ichinose, Fumito, Zapol, Warren M.
Publicado 2017

sGCα(1)β(1 )attenuates cardiac dysfunction and mortality in murine inflammatory shock models

por Buys, Emmanuel S, Cauwels, Anje, Raher, Michael J, Passeri, Jonathan J, Hobai, Ion, Cawley, Sharon M, Rauwerdink, Kristen M, Thibault, Helene, Sips, Patrick Y, Thoonen, Robrecht, Scherrer-Crosbie, Marielle, Ichinose, Fumito, Brouckaert, Peter, Bloch, Kenneth D
Publicado 2009

Cardiovascular and pharmacological implications of haem-deficient NO-unresponsive soluble guanylate cyclase knock-in mice

por Thoonen, Robrecht, Cauwels, Anje, Decaluwe, Kelly, Geschka, Sandra, Tainsh, Robert E., Delanghe, Joris, Hochepied, Tino, De Cauwer, Lode, Rogge, Elke, Voet, Sofie, Sips, Patrick, Karas, Richard H., Bloch, Kenneth D., Vuylsteke, Marnik, Stasch, Johannes-Peter, Van de Voorde, Johan, Buys, Emmanuel S., Brouckaert, Peter
Publicado 2015

Identification of specific metabolic pathways as druggable targets regulating the sensitivity to cyanide poisoning

por Sips, Patrick Y., Shi, Xu, Musso, Gabriel, Nath, Anjali K., Zhao, Yanbin, Nielson, Jason, Morningstar, Jordan, Kelly, Amy E., Mikell, Brittney, Buys, Eva, Bebarta, Vikhyat, Rutter, Jared, Davisson, V. Jo, Mahon, Sari, Brenner, Matthew, Boss, Gerry R., Peterson, Randall T., Gerszten, Robert E., MacRae, Calum A.
Publicado 2018

Androgen-sensitive hypertension associated with soluble guanylate cyclase alpha1 deficiency is mediated by 20-HETE

por Vandenwijngaert, Sara, Dordea, Ana C, Garcia, Victor, Tainsh, Robert E, Nathan, Daniel I, Raher, Michael J, Allen, Kaitlin, Zhang, Fan, Lieb, Wolfgang S, Mikelman, Sarah, Kirby, Andrew, Stevens, Christine, Thoonen, Robrecht, Hindle, Allyson, Sips, Patrick Y, Malhotra, Rajeev, Daly, Mark J, Brouckaert, Peter, Bloch, Kenneth D, Schwartzman, Michal, Buys, Emmanuel S
Publicado 2015

Zebrafish type I collagen mutants faithfully recapitulate human type I collagenopathies

por Gistelinck, Charlotte, Kwon, Ronald Y., Malfait, Fransiska, Symoens, Sofie, Harris, Matthew P., Henke, Katrin, Hawkins, Michael B., Fisher, Shannon, Sips, Patrick, Guillemyn, Brecht, Bek, Jan Willem, Vermassen, Petra, De Saffel, Hanna, Witten, Paul Eckhard, Weis, MaryAnn, De Paepe, Anne, Eyre, David R., Willaert, Andy, Coucke, Paul J.
Publicado 2018

Wars2 is a determinant of angiogenesis

por Wang, Mao, Sips, Patrick, Khin, Ester, Rotival, Maxime, Sun, Ximing, Ahmed, Rizwan, Widjaja, Anissa Anindya, Schafer, Sebastian, Yusoff, Permeen, Choksi, Pervinder Kaur, Ko, Nicole Shi Jie, Singh, Manvendra K., Epstein, David, Guan, Yuguang, Houštěk, Josef, Mracek, Tomas, Nuskova, Hana, Mikell, Brittney, Tan, Jessie, Pesce, Francesco, Kolar, Frantisek, Bottolo, Leonardo, Mancini, Massimiliano, Hubner, Norbert, Pravenec, Michal, Petretto, Enrico, MacRae, Calum, Cook, Stuart A
Publicado 2016

Glyoxylate protects against cyanide toxicity through metabolic modulation

por Nielson, Jason R., Nath, Anjali K., Doane, Kim P., Shi, Xu, Lee, Jangwoen, Tippetts, Emily G., Saha, Kusumika, Morningstar, Jordan, Hicks, Kevin G., Chan, Adriano, Zhao, Yanbin, Kelly, Amy, Hendry-Hofer, Tara B., Witeof, Alyssa, Sips, Patrick Y., Mahon, Sari, Bebarta, Vikhyat S., Davisson, Vincent Jo, Boss, Gerry R., Rutter, Jared, MacRae, Calum A., Brenner, Matthew, Gerszten, Robert E., Peterson, Randall T.
Publicado 2022