RNAi screen identifies a role for adaptor protein AP-3 in sorting to the regulated secretory pathway

por Asensio, Cédric S., Sirkis, Daniel W., Edwards, Robert H.
Publicado 2010

Widespread Dysregulation of Peptide Hormone Release in Mice Lacking Adaptor Protein AP-3

por Sirkis, Daniel W., Edwards, Robert H., Asensio, Cédric S.
Publicado 2013

Neurodegeneration-associated mutant TREM2 proteins abortively cycle between the ER and ER–Golgi intermediate compartment

por Sirkis, Daniel W., Aparicio, Renan E., Schekman, Randy
Publicado 2017

The Transcriptional Landscape of Microglial Genes in Aging and Neurodegenerative Disease

por Bonham, Luke W., Sirkis, Daniel W., Yokoyama, Jennifer S.
Publicado 2019

The Role of Microglia in Inherited White-Matter Disorders and Connections to Frontotemporal Dementia

por Sirkis, Daniel W, Bonham, Luke W, Yokoyama, Jennifer S
Publicado 2021

Dissecting the clinical heterogeneity of early-onset Alzheimer’s disease

por Sirkis, Daniel W., Bonham, Luke W., Johnson, Taylor P., La Joie, Renaud, Yokoyama, Jennifer S.
Publicado 2022

Unconventional secretion of α-synuclein mediated by palmitoylated DNAJC5 oligomers

por Wu, Shenjie, Hernandez Villegas, Nancy C, Sirkis, Daniel W, Thomas-Wright, Iona, Wade-Martins, Richard, Schekman, Randy
Publicado 2023

C9orf72 gene networks in the human brain correlate with cortical thickness in C9-FTD and implicate vulnerable cell types

por Broce, Iris J., Sirkis, Daniel W., Nillo, Ryan M., Bonham, Luke W., Lee, Suzee E., Miller, Bruce, Castruita, Patricia, Sturm, Virginia E., Sugrue, Leo S., Desikan, Rahul S., Yokoyama, Jennifer S.
Publicado 2023

Rare TREM2 variants associated with Alzheimer’s disease display reduced cell surface expression

por Sirkis, Daniel W., Bonham, Luke W., Aparicio, Renan E., Geier, Ethan G., Ramos, Eliana Marisa, Wang, Qing, Karydas, Anna, Miller, Zachary A., Miller, Bruce L., Coppola, Giovanni, Yokoyama, Jennifer S.
Publicado 2016

Single-cell RNA-seq reveals alterations in peripheral CX3CR1 and nonclassical monocytes in familial tauopathy

por Sirkis, Daniel W., Warly Solsberg, Caroline, Johnson, Taylor P., Bonham, Luke W., Sturm, Virginia E., Lee, Suzee E., Rankin, Katherine P., Rosen, Howard J., Boxer, Adam L., Seeley, William W., Miller, Bruce L., Geier, Ethan G., Yokoyama, Jennifer S.
Publicado 2023

Frontotemporal dementia presentation in patients with heterozygous p.H157Y variant of TREM2

por Ogonowski, Natalia, Santamaria-Garcia, Hernando, Baez, Sandra, Lopez, Andrea, Laserna, Andrés, Garcia-Cifuentes, Elkin, Ayala-Ramirez, Paola, Zarante, Ignacio, Suarez-Obando, Fernando, Reyes, Pablo, Kauffman, Marcelo, Cochran, Nick, Schulte, Michael, Sirkis, Daniel W, Spina, Salvatore, Yokoyama, Jennifer S, Miller, Bruce L, Kosik, Kenneth S, Matallana, Diana, Ibáñez, Agustín
Publicado 2023

Early‐onset Alzheimer's disease explained by polygenic risk of late‐onset disease?

por Mantyh, William G., Cochran, J. Nicholas, Taylor, Jared W., Broce, Iris J., Geier, Ethan G., Bonham, Luke W., Anderson, Ashlyn G., Sirkis, Daniel W., Joie, Renaud La, Iaccarino, Leonardo, Chaudhary, Kiran, Edwards, Lauren, Strom, Amelia, Grant, Harli, Allen, Isabel E., Miller, Zachary A., Gorno‐Tempini, Marilu L., Kramer, Joel H., Miller, Bruce L., Desikan, Rahul S., Rabinovici, Gil D., Yokoyama, Jennifer S.
Publicado 2023

FTLD targets brain regions expressing recently evolved genes

por Pasquini, Lorenzo, Pereira, Felipe L., Seddighi, Sahba, Zeng, Yi, Wei, Yongbin, Illán-Gala, Ignacio, Vatsavayai, Sarat C., Friedberg, Adit, Lee, Alex J., Brown, Jesse A., Spina, Salvatore, Grinberg, Lea T., Sirkis, Daniel W., Bonham, Luke W., Yokoyama, Jennifer S., Boxer, Adam L., Kramer, Joel H., Rosen, Howard J., Humphrey, Jack, Gitler, Aaron D., Miller, Bruce L., Pollard, Katherine S., Ward, Michael E., Seeley, William W.
Publicado 2023

Radiogenomics of C9orf72 Expansion Carriers Reveals Global Transposable Element Derepression and Enables Prediction of Thalamic Atrophy and Clinical Impairment

por Bonham, Luke W., Geier, Ethan G., Sirkis, Daniel W., Leong, Josiah K., Ramos, Eliana Marisa, Wang, Qing, Karydas, Anna, Lee, Suzee E., Sturm, Virginia E., Sawyer, Russell P., Friedberg, Adit, Ichida, Justin K., Gitler, Aaron D., Sugrue, Leo, Cordingley, Michael, Bee, Walter, Weber, Eckard, Kramer, Joel H., Rankin, Katherine P., Rosen, Howard J., Boxer, Adam L., Seeley, William W., Ravits, John, Miller, Bruce L., Yokoyama, Jennifer S.
Publicado 2023