The gain-of-function GLI1 transcription factor TGLI1 enhances expression of VEGF-C and TEM7 to promote glioblastoma angiogenesis

por Carpenter, Richard L., Paw, Ivy, Zhu, Hu, Sirkisoon, Sherona, Xing, Fei, Watabe, Kounosuke, Debinski, Waldemar, Lo, Hui-Wen
Publicado 2015

Interaction between STAT3 and GLI1/tGLI1 oncogenic transcription factors promotes the aggressiveness of triple-negative and HER2-enriched breast cancers

por Sirkisoon, Sherona R., Carpenter, Richard L., Rimkus, Tadas, Anderson, Ashley, Harrison, Alexandria, Lange, Allison M., Jin, Guangxu, Watabe, Kounosuke, Lo, Hui-Wen
Publicado 2018

54. tGLI1 IS AN ACTIONABLE THERAPEUTIC TARGET IN BREAST CANCER BRAIN METASTASES

por Doheny, Daniel, Sirkisoon, Sherona, Rimkus, Tadas, Zhu, Dongqin, Aguayo, Noah, Anguelov, Marlyn, Manore, Sara, Regua, Angelina, Thomas, Alexandra, Henson-Masters, Adrianna, Strowd, Roy, Lo, Hui-Wen
Publicado 2020

Her2 promotes early dissemination of breast cancer by suppressing the p38 pathway through Skp2-mediated proteasomal degradation of Tpl2

por Wang, Guanwen, Wang, Juan, Chang, Antao, Cheng, Dongmei, Huang, Shan, Wu, Dan, Sirkisoon, Sherona, Yang, Shuang, Lin, Hui-Kuan, Lo, Hui-Wen, Xiang, Rong, Sun, Peiqing
Publicado 2020

BSCI-13. TUMOR-SPECIFIC tGLI1 TRANSCRIPTION FACTOR MEDIATES BREAST CANCER BRAIN METASTASIS VIA ACTIVATING METASTASIS-INITIATING CANCER STEM CELLS AND ASTROCYTES IN THE TUMOR MICROE...

por Sirkisoon, Sherona, Carpenter, Richard, Rimkus, Tadas, Doheny, Daniel, Zhu, Dongqin, Aguayo, Noah, Anguelov, Marlyn, Arrigo, Austin, Regua, Angelina, Xing, Fei, Chan, Michael, Metheny-Barlow, Linda, Watabe, Kounosuke, Lo, Hui-Wen
Publicado 2019

BSCI-02. tGLI1 IS A NOVEL, ACTIONABLE TARGET FOR THE TREATMENT OF BREAST CANCER BRAIN METASTASES

por Doheny, Daniel, Sirkisoon, Sherona, Rimkus, Tadas, Zhu, Dongqin, Aguayo, Noah, Harrison, Alexandria, Anguelov, Marlyn, Xing, Fei, Metheny-Barlow, Linda, Watabe, Kounosuke, Thomas, Alexandra, Masters, Adrianna Henson, Strowd, Roy, Lo, Hui-Wen
Publicado 2019

BSCI-14. tGLI1 is an actionable therapeutic target in breast cancer brain metastases

por Doheny, Daniel, Manore, Sara, Wong, Grace, Zhu, Dongqin, Sirkisoon, Sherona, Rimkus, Tadas, Anguelov, Marlyn, Aguayo, Noah, Regua, Angelina, Cox, Anderson O’Brian, Furdui, Cristina, Thomas, Alexandra, Masters, Adrianna Henson, Strowd, Roy, Lo, Hui-Wen
Publicado 2021

Combined inhibition of AKT and HSF1 suppresses breast cancer stem cells and tumor growth

por Carpenter, Richard L., Sirkisoon, Sherona, Zhu, Dongqin, Rimkus, Tadas, Harrison, Alexandria, Anderson, Ashley, Paw, Ivy, Qasem, Shadi, Xing, Fei, Liu, Yin, Chan, Michael, Metheny-Barlow, Linda, Pasche, Boris C., Debinski, Waldemar, Watabe, Kounosuke, Lo, Hui-Wen
Publicado 2017

An FDA-Approved Antifungal, Ketoconazole, and Its Novel Derivative Suppress tGLI1-Mediated Breast Cancer Brain Metastasis by Inhibiting the DNA-Binding Activity of Brain Metastasis...

por Doheny, Daniel, Manore, Sara, Sirkisoon, Sherona R., Zhu, Dongqin, Aguayo, Noah R., Harrison, Alexandria, Najjar, Mariana, Anguelov, Marlyn, Cox, Anderson O’Brien, Furdui, Cristina M., Watabe, Kounosuke, Hollis, Thomas, Thomas, Alexandra, Strowd, Roy, Lo, Hui-Wen
Publicado 2022

TGLI1 transcription factor mediates breast cancer brain metastasis via activating metastasis-initiating cancer stem cells and astrocytes in the tumor microenvironment

por Sirkisoon, Sherona R., Carpenter, Richard L., Rimkus, Tadas, Doheny, Daniel, Zhu, Dongqin, Aguayo, Noah R., Xing, Fei, Chan, Michael, Ruiz, Jimmy, Metheny-Barlow, Linda J., Strowd, Roy, Lin, Jiayuh, Pasche, Boris, Debinski, Waldemar, Watabe, Kounosuke, Lo, Hui-Wen
Publicado 2019

Combined inhibition of JAK2-STAT3 and SMO-GLI1/tGLI1 pathways suppresses breast cancer stem cells, tumor growth, and metastasis

por Doheny, Daniel, Sirkisoon, Sherona, Carpenter, Richard L., Aguayo, Noah Reeve, Regua, Angelina T., Anguelov, Marlyn, Manore, Sara G., Arrigo, Austin, Jalboush, Sara Abu, Wong, Grace L., Yu, Yang, Wagner, Calvin J., Chan, Michael, Ruiz, Jimmy, Thomas, Alexandra, Strowd, Roy, Lin, Jiayuh, Lo, Hui-Wen
Publicado 2020