Donald Lowell Price, M.D. In memoriam

por Sisodia, Sangram, Wong, Philip C.
Publicado 2023

The topology of pen-2, a γ-secretase subunit, revisited: evidence for a reentrant loop and a single pass transmembrane domain

por Zhang, Xulun, Yu, Chunjiang J., Sisodia, Sangram S.
Publicado 2015

The gut microbiome in Alzheimer’s disease: what we know and what remains to be explored

por Chandra, Sidhanth, Sisodia, Sangram S., Vassar, Robert J.
Publicado 2023

Endogenous expression of FAD-linked PS1 impairs proliferation, neuronal differentiation and survival of adult hippocampal progenitors

por Veeraraghavalu, Karthikeyan, Choi, Se Hoon, Zhang, Xiaoqiong, Sisodia, Sangram S
Publicado 2013

Regulation of hippocampal progenitor cell survival, proliferation and dendritic development by BDNF

por Choi, Se Hoon, Li, Yun, Parada, Luis F, Sisodia, Sangram S
Publicado 2009

Biogenesis of γ-secretase early in the secretory pathway

por Kim, Jinoh, Kleizen, Bertrand, Choy, Regina, Thinakaran, Gopal, Sisodia, Sangram S., Schekman, Randy W.
Publicado 2007

Nanoscale organization of Nicastrin, the substrate receptor of the γ-secretase complex, as independent molecular domains

por Kedia, Shekhar, Mandal, Kousik, Netrakanti, Pallavi Rao, Jose, Mini, Sisodia, Sangram S., Nair, Deepak
Publicado 2021

Dual Roles for Ste24p in Yeast a-Factor Maturation: NH(2)-terminal Proteolysis and COOH-terminal CAAX Processing

por Tam, Amy, Nouvet, Franklin J., Fujimura-Kamada, Konomi, Slunt, Hilda, Sisodia, Sangram S., Michaelis, Susan
Publicado 1998

Increased Expression of PS1 Is Sufficient to Elevate the Level and Activity of γ-Secretase In Vivo

por Li, Tong, Li, Yue-Ming, Ahn, Kwangwook, Price, Donald L., Sisodia, Sangram S., Wong, Philip C.
Publicado 2011

Synergistic depletion of gut microbial consortia, but not individual antibiotics, reduces amyloidosis in APPPS1-21 Alzheimer’s transgenic mice

por Dodiya, Hemraj B., Frith, Mary, Sidebottom, Ashley, Cao, Yajun, Koval, Jason, Chang, Eugene, Sisodia, Sangram S.
Publicado 2020

Molecular signatures of neurodegeneration in the cortex of PS1/PS2 double knockout mice

por Mirnics, Károly, Norstrom, Eric M, Garbett, Krassimira, Choi, Se Hoon, Zhang, Xiaoqiong, Ebert, Philip, Sisodia, Sangram S
Publicado 2008

Increased Type I interferon signaling and brain endothelial barrier dysfunction in an experimental model of Alzheimer’s disease

por Jana, Arundhati, Wang, Xinge, Leasure, Joseph W., Magana, Lissette, Wang, Li, Kim, Young-Mee, Dodiya, Hemraj, Toth, Peter T., Sisodia, Sangram S., Rehman, Jalees
Publicado 2022

Alteration in synaptic nanoscale organization dictates amyloidogenic processing in Alzheimer's disease

por Kedia, Shekhar, Ramakrishna, Pratyush, Netrakanti, Pallavi Rao, Singh, Nivedita, Sisodia, Sangram S., Jose, Mini, Kumar, Sathish, Mahadevan, Anita, Ramanan, Narendrakumar, Nadkarni, Suhita, Nair, Deepak
Publicado 2020

The gut microbiome regulates astrocyte reaction to Aβ amyloidosis through microglial dependent and independent mechanisms

por Chandra, Sidhanth, Di Meco, Antonio, Dodiya, Hemraj B., Popovic, Jelena, Cuddy, Leah K., Weigle, Ian Q., Zhang, Xiaoqiong, Sadleir, Katherine, Sisodia, Sangram S., Vassar, Robert
Publicado 2023

An APP ectodomain mutation outside of the Aβ domain promotes Aβ production in vitro and deposition in vivo

por Zhang, Xulun, Zhang, Can Martin, Prokopenko, Dmitry, Liang, Yingxia, Zhen, Sherri Y., Weigle, Ian Q., Han, Weinong, Aryal, Manish, Tanzi, Rudolph E., Sisodia, Sangram S.
Publicado 2021

Sex-specific effects of microbiome perturbations on cerebral Aβ amyloidosis and microglia phenotypes

por Dodiya, Hemraj B., Kuntz, Thomas, Shaik, Shabana M., Baufeld, Caroline, Leibowitz, Jeffrey, Zhang, Xulun, Gottel, Neil, Zhang, Xiaoqiong, Butovsky, Oleg, Gilbert, Jack A., Sisodia, Sangram S.
Publicado 2019

Soluble γ-Secretase Modulators Selectively Inhibit the Production of the 42-Amino Acid Amyloid β Peptide Variant and Augment the Production of Multiple Carboxy-Truncated Amyloid β...

por Wagner, Steven L., Zhang, Can, Cheng, Soan, Nguyen, Phuong, Zhang, Xulun, Rynearson, Kevin D., Wang, Rong, Li, Yueming, Sisodia, Sangram S., Mobley, William C., Tanzi, Rudolph E.
Publicado 2014

BAD-mediated neuronal apoptosis and neuroinflammation contribute to Alzheimer's disease pathology

por Zhang, Liansheng, Qian, Yun, Li, Jie, Zhou, Xuan, Xu, He, Yan, Jie, Xiang, Jialing, Yuan, Xiang, Sun, Beicheng, Sisodia, Sangram S., Jiang, Yong-Hui, Cao, Xiaohua, Jing, Naihe, Lin, Anning
Publicado 2021

Antibiotic-induced perturbations in microbial diversity during post-natal development alters amyloid pathology in an aged APP(SWE)/PS1(ΔE9) murine model of Alzheimer’s disease

por Minter, Myles R., Hinterleitner, Reinhard, Meisel, Marlies, Zhang, Can, Leone, Vanessa, Zhang, Xiaoqiong, Oyler-Castrillo, Paul, Zhang, Xulun, Musch, Mark W., Shen, Xunuo, Jabri, Bana, Chang, Eugene B., Tanzi, Rudolph E., Sisodia, Sangram S.
Publicado 2017

Antibiotic-induced perturbations in gut microbial diversity influences neuro-inflammation and amyloidosis in a murine model of Alzheimer’s disease

por Minter, Myles R., Zhang, Can, Leone, Vanessa, Ringus, Daina L., Zhang, Xiaoqiong, Oyler-Castrillo, Paul, Musch, Mark W., Liao, Fan, Ward, Joseph F., Holtzman, David M., Chang, Eugene B., Tanzi, Rudolph E., Sisodia, Sangram S.
Publicado 2016