Identification of flucloxacillin-modified hepatocellular proteins: implications in flucloxacillin-induced liver injury

por Ali, Serat-E, Waddington, James C, Lister, Adam, Sison-Young, Rowena, Jones, Robert P, Rehman, Adeeb H, Goldring, Chris E P, Naisbitt, Dean J, Meng, Xiaoli
Publicado 2023

Donor‐Dependent and Other Nondefined Factors Have Greater Influence on the Hepatic Phenotype Than the Starting Cell Type in Induced Pluripotent Stem Cell Derived Hepatocyte‐Like Ce...

por Heslop, James A., Kia, Richard, Pridgeon, Christopher S., Sison‐Young, Rowena L., Liloglou, Triantafillos, Elmasry, Mohamed, Fenwick, Stephen W., Mills, John S., Kitteringham, Neil R., Goldring, Chris E., Park, Bong K.
Publicado 2017

Detection of Hepatic Drug Metabolite-Specific T-Cell Responses Using a Human Hepatocyte, Immune Cell Coculture System

por Ali, Serat-E, Meng, Xiaoli, Kafu, Laila, Hammond, Sean, Zhao, Qing, Ogese, Monday, Sison-Young, Rowena, Jones, Robert, Chan, Benjamin, Livoti, Lucia, Sun, Yonghu, Sun, Lele, Liu, Hong, Topping, Anthony, Goldring, Christopher, Zhang, Furen, Naisbitt, Dean John
Publicado 2023

Mechanistic evaluation of primary human hepatocyte culture using global proteomic analysis reveals a selective dedifferentiation profile

por Heslop, James A., Rowe, Cliff, Walsh, Joanne, Sison-Young, Rowena, Jenkins, Roz, Kamalian, Laleh, Kia, Richard, Hay, David, Jones, Robert P., Malik, Hassan Z., Fenwick, Stephen, Chadwick, Amy E., Mills, John, Kitteringham, Neil R., Goldring, Chris E. P., Kevin Park, B.
Publicado 2016

Comparative Proteomic Characterization of 4 Human Liver-Derived Single Cell Culture Models Reveals Significant Variation in the Capacity for Drug Disposition, Bioactivation, and De...

por Sison-Young, Rowena L. C., Mitsa, Dimitra, Jenkins, Rosalind E., Mottram, David, Alexandre, Eliane, Richert, Lysiane, Aerts, Hélène, Weaver, Richard J., Jones, Robert P., Johann, Esther, Hewitt, Philip G., Ingelman-Sundberg, Magnus, Goldring, Christopher E. P., Kitteringham, Neil R., Park, B. Kevin
Publicado 2015

Phenotypic and functional analyses show stem cell-derived hepatocyte-like cells better mimic fetal rather than adult hepatocytes

por Baxter, Melissa, Withey, Sarah, Harrison, Sean, Segeritz, Charis-Patricia, Zhang, Fang, Atkinson-Dell, Rebecca, Rowe, Cliff, Gerrard, Dave T., Sison-Young, Rowena, Jenkins, Roz, Henry, Joanne, Berry, Andrew A., Mohamet, Lisa, Best, Marie, Fenwick, Stephen W., Malik, Hassan, Kitteringham, Neil R., Goldring, Chris E., Piper Hanley, Karen, Vallier, Ludovic, Hanley, Neil A.
Publicado 2015

Model-based identification of TNFα-induced IKKβ-mediated and IκBα-mediated regulation of NFκB signal transduction as a tool to quantify the impact of drug-induced liver injury comp...

por Oppelt, Angela, Kaschek, Daniel, Huppelschoten, Suzanna, Sison-Young, Rowena, Zhang, Fang, Buck-Wiese, Marie, Herrmann, Franziska, Malkusch, Sebastian, Krüger, Carmen L., Meub, Mara, Merkt, Benjamin, Zimmermann, Lea, Schofield, Amy, Jones, Robert P., Malik, Hassan, Schilling, Marcel, Heilemann, Mike, van de Water, Bob, Goldring, Christopher E., Park, B. Kevin, Timmer, Jens, Klingmüller, Ursula
Publicado 2018

Characterization of primary human hepatocyte spheroids as a model system for drug-induced liver injury, liver function and disease

por Bell, Catherine C., Hendriks, Delilah F. G., Moro, Sabrina M. L., Ellis, Ewa, Walsh, Joanne, Renblom, Anna, Fredriksson Puigvert, Lisa, Dankers, Anita C. A., Jacobs, Frank, Snoeys, Jan, Sison-Young, Rowena L., Jenkins, Rosalind E., Nordling, Åsa, Mkrtchian, Souren, Park, B. Kevin, Kitteringham, Neil R., Goldring, Christopher E. P., Lauschke, Volker M., Ingelman-Sundberg, Magnus
Publicado 2016

Innovative organotypic in vitro models for safety assessment: aligning with regulatory requirements and understanding models of the heart, skin, and liver as paradigms

por Pridgeon, Chris S., Schlott, Constanze, Wong, Min Wei, Heringa, Minne B., Heckel, Tobias, Leedale, Joe, Launay, Laurence, Gryshkova, Vitalina, Przyborski, Stefan, Bearon, Rachel N., Wilkinson, Emma L., Ansari, Tahera, Greenman, John, Hendriks, Delilah F. G., Gibbs, Sue, Sidaway, James, Sison-Young, Rowena L., Walker, Paul, Cross, Mike J., Park, B. Kevin, Goldring, Chris E. P.
Publicado 2018

Comparison of Hepatic 2D Sandwich Cultures and 3D Spheroids for Long-term Toxicity Applications: A Multicenter Study

por Bell, Catherine C, Dankers, Anita C A, Lauschke, Volker M, Sison-Young, Rowena, Jenkins, Roz, Rowe, Cliff, Goldring, Chris E, Park, Kevin, Regan, Sophie L, Walker, Tracy, Schofield, Chris, Baze, Audrey, Foster, Alison J, Williams, Dominic P, van de Ven, Amy W M, Jacobs, Frank, van Houdt, Jos, Lähteenmäki, Tuula, Snoeys, Jan, Juhila, Satu, Richert, Lysiane, Ingelman-Sundberg, Magnus
Publicado 2018

A systems approach reveals species differences in hepatic stress response capacity

por Russomanno, Giusy, Sison-Young, Rowena, Livoti, Lucia A, Coghlan, Hannah, Jenkins, Rosalind E, Kunnen, Steven J, Fisher, Ciarán P, Reddyhoff, Dennis, Gardner, Iain, Rehman, Adeeb H, Fenwick, Stephen W, Jones, Andrew R, Vermeil De Conchard, Guy, Simonin, Gilles, Bertheux, Helene, Weaver, Richard J, Johnson, Robert L, Liguori, Michael J, Clausznitzer, Diana, Stevens, James L, Goldring, Christopher E, Copple, Ian M
Publicado 2023

A multicenter assessment of single-cell models aligned to standard measures of cell health for prediction of acute hepatotoxicity

por Sison-Young, Rowena L., Lauschke, Volker M., Johann, Esther, Alexandre, Eliane, Antherieu, Sébastien, Aerts, Hélène, Gerets, Helga H. J., Labbe, Gilles, Hoët, Delphine, Dorau, Martina, Schofield, Christopher A., Lovatt, Cerys A., Holder, Julie C., Stahl, Simone H., Richert, Lysiane, Kitteringham, Neil R., Jones, Robert P., Elmasry, Mohamed, Weaver, Richard J., Hewitt, Philip G., Ingelman-Sundberg, Magnus, Goldring, Chris E., Park, B. Kevin
Publicado 2016

MicroRNA-122: A Novel Hepatocyte-Enriched in vitro Marker of Drug-Induced Cellular Toxicity

por Kia, Richard, Kelly, Lorna, Sison-Young, Rowena L. C., Zhang, Fang, Pridgeon, Chris S., Heslop, James A., Metcalfe, Pete, Kitteringham, Neil R., Baxter, Melissa, Harrison, Sean, Hanley, Neil A., Burke, Zoë D., Storm, Mike P., Welham, Melanie J., Tosh, David, Küppers-Munther, Barbara, Edsbagge, Josefina, Starkey Lewis, Philip J., Bonner, Frank, Harpur, Ernie, Sidaway, James, Bowes, Joanne, Fenwick, Stephen W., Malik, Hassan, Goldring, Chris E. P., Park, B. Kevin
Publicado 2015