Aberrant Cholesterol Metabolism in Ovarian Cancer: Identification of Novel Therapeutic Targets

por He, Jiangnan, Siu, Michelle K.Y., Ngan, Hextan Y. S., Chan, Karen K. L.
Publicado 2021

Molecular Biomarkers for the Early Detection of Ovarian Cancer

por Zhang, Ruiqian, Siu, Michelle K. Y., Ngan, Hextan Y. S., Chan, Karen K. L.
Publicado 2022

Orchestrated Action of AMPK Activation and Combined VEGF/PD-1 Blockade with Lipid Metabolic Tunning as Multi-Target Therapeutics against Ovarian Cancers

por Yung, Mingo M. H., Siu, Michelle K. Y., Ngan, Hextan Y. S., Chan, David W., Chan, Karen K. L.
Publicado 2022

Downregulation of the Gli Transcription Factors Regulator Kif7 Facilitates Cell Survival and Migration of Choriocarcinoma Cells

por Ho, Joanna, Du, Yanan, Wong, Oscar Gee-Wan, Siu, Michelle K. Y., Chan, Karen K. L., Cheung, Annie N. Y.
Publicado 2014

Estrogen receptor modulators genistein, daidzein and ERB-041 inhibit cell migration, invasion, proliferation and sphere formation via modulation of FAK and PI3K/AKT signaling in ov...

por Chan, Karen K. L., Siu, Michelle K. Y., Jiang, Yu-xin, Wang, Jing-jing, Leung, Thomas H. Y., Ngan, Hextan Y. S.
Publicado 2018

New Insights into Ferroptosis Initiating Therapies (FIT) by Targeting the Rewired Lipid Metabolism in Ovarian Cancer Peritoneal Metastases

por Zhan, Shijie, Yung, Mingo M. H., Siu, Michelle K. Y., Jiao, Peili, Ngan, Hextan Y. S., Chan, David W., Chan, Karen K. L.
Publicado 2022

PDK1 promotes ovarian cancer metastasis by modulating tumor-mesothelial adhesion, invasion, and angiogenesis via α5β1 integrin and JNK/IL-8 signaling

por Siu, Michelle K. Y., Jiang, Yu-xin, Wang, Jing-jing, Leung, Thomas H. Y., Ngu, Siew Fei, Cheung, Annie N. Y., Ngan, Hextan Y. S., Chan, Karen K. L.
Publicado 2020

PFKFB3 Regulates Chemoresistance, Metastasis and Stemness via IAP Proteins and the NF-κB Signaling Pathway in Ovarian Cancer

por Jiang, Yu-xin, Siu, Michelle K. Y., Wang, Jing-jing, Leung, Thomas H. Y., Chan, David W., Cheung, Annie N. Y., Ngan, Hextan Y. S., Chan, Karen K. L.
Publicado 2022

Differential expression of estrogen receptor subtypes and variants in ovarian cancer: effects on cell invasion, proliferation and prognosis

por Chan, Karen K. L., Siu, Michelle K. Y., Jiang, Yu-xin, Wang, Jing-jing, Wang, Yan, Leung, Thomas H. Y., Liu, Stephanie S., Cheung, Annie N. Y., Ngan, Hextan Y. S.
Publicado 2017

Paradoxical Impact of Two Folate Receptors, FRα and RFC, in Ovarian Cancer: Effect on Cell Proliferation, Invasion and Clinical Outcome

por Siu, Michelle K. Y., Kong, Daniel S. H., Chan, Hoi Yan, Wong, Esther S. Y., Ip, Philip P. C., Jiang, LiLi, Ngan, Hextan Y. S., Le, Xiao-Feng, Cheung, Annie N. Y.
Publicado 2012

Hexokinase 2 Regulates Ovarian Cancer Cell Migration, Invasion and Stemness via FAK/ERK1/2/MMP9/NANOG/SOX9 Signaling Cascades

por Siu, Michelle K. Y., Jiang, Yu-Xin, Wang, Jing-Jing, Leung, Thomas H. Y., Han, Chae Young, Tsang, Benjamin K., Cheung, Annie N. Y., Ngan, Hextan Y. S., Chan, Karen K. L.
Publicado 2019

p21-Activated Kinases 1, 2 and 4 in Endometrial Cancers: Effects on Clinical Outcomes and Cell Proliferation

por Siu, Michelle K. Y., Kong, Daniel S. H., Ngai, Sheila Y. P., Chan, Hoi Yan, Jiang, Lili, Wong, Esther S. Y., Liu, Stephanie S., Chan, Karen K. L., Ngan, Hextan Y. S., Cheung, Annie N. Y.
Publicado 2015

Overexpression of Forkhead Box Protein M1 (FOXM1) in Ovarian Cancer Correlates with Poor Patient Survival and Contributes to Paclitaxel Resistance

por Zhao, Fung, Siu, Michelle K. Y., Jiang, LiLi, Tam, Kar Fai, Ngan, Hextan Y. S., Le, Xiao Feng, Wong, Oscar G. W., Wong, Esther S. Y., Gomes, Ana R., Bella, Laura, Khongkow, Pasarat, Lam, Eric W-F, Cheung, Annie N. Y.
Publicado 2014

Tumor-secreted exosomal miR-141 activates tumor-stroma interactions and controls premetastatic niche formation in ovarian cancer metastasis

por Mo, Yulan, Leung, Leanne L., Mak, Celia S. L., Wang, Xueyu, Chan, Wai-Sun, Hui, Lynn M. N., Tang, Hermit W. M., Siu, Michelle K. Y., Sharma, Rakesh, Xu, Dakang, Tsui, Stephen K. W., Ngan, Hextan Y. S., Yung, Mingo M. H., Chan, Karen K. L., Chan, David W.
Publicado 2023

Nuclear HKII-P-p53 (Ser15) Interaction is a Prognostic Biomarker for Chemoresponsiveness and Glycolytic Regulation in Epithelial Ovarian Cancer

por Han, Chae Young, Patten, David A., Kim, Se Ik, Lim, Jung Jin, Chan, David W., Siu, Michelle K. Y., Han, Youngjin, Carmona, Euridice, Parks, Robin J., Lee, Cheol, Di, Li-Jun, Lu, Zhen, Chan, Karen K. L., Ku, Ja-Lok, Macdonald, Elizabeth A., Vanderhyden, Barbara C., Mes-Masson, Anne-Marie, Ngan, Hextan Y. S., Cheung, Annie N. Y., Song, Yong Sang, Bast, Robert C., Harper, Mary-Ellen, Tsang, Benjamin K.
Publicado 2021