AI revolutions in biology: The joys and perils of AlphaFold

por Perrakis, Anastassis, Sixma, Titia K
Publicado 2021

Intrinsic Flexibility of Ubiquitin on Proliferating Cell Nuclear Antigen (PCNA) in Translesion Synthesis

por Hibbert, Richard G., Sixma, Titia K.
Publicado 2012

Structure of UBE2Z Enzyme Provides Functional Insight into Specificity in the FAT10 Protein Conjugation Machinery

por Schelpe, Julien, Monté, Didier, Dewitte, Frédérique, Sixma, Titia K., Rucktooa, Prakash
Publicado 2016

The DUSP–Ubl domain of USP4 enhances its catalytic efficiency by promoting ubiquitin exchange

por Clerici, Marcello, Luna-Vargas, Mark P. A., Faesen, Alex C., Sixma, Titia K.
Publicado 2014

A conserved two-step binding for the UAF1 regulator to the USP12 deubiquitinating enzyme

por Dharadhar, Shreya, Clerici, Marcello, van Dijk, Willem J., Fish, Alexander, Sixma, Titia K.
Publicado 2016

Insert L1 is a central hub for allosteric regulation of USP1 activity

por Dharadhar, Shreya, van Dijk, Willem J, Scheffers, Serge, Fish, Alexander, Sixma, Titia K
Publicado 2021

The nucleosome acidic patch plays a critical role in RNF168-dependent ubiquitination of histone H2A

por Mattiroli, Francesca, Uckelmann, Michael, Sahtoe, Danny D., van Dijk, Willem J., Sixma, Titia K.
Publicado 2014

BAP1/ASXL1 recruitment and activation for H2A deubiquitination

por Sahtoe, Danny D., van Dijk, Willem J., Ekkebus, Reggy, Ovaa, Huib, Sixma, Titia K.
Publicado 2016

Erratum: The nucleosome acidic patch plays a critical role in RNF168-dependent ubiquitination of histone H2A

por Mattiroli, Francesca, Uckelmann, Michael, Sahtoe, Danny D., van Dijk, Willem J., Sixma, Titia K.
Publicado 2014

Structural Characterization of Binding Mode of Smoking Cessation Drugs to Nicotinic Acetylcholine Receptors through Study of Ligand Complexes with Acetylcholine-binding Protein

por Rucktooa, Prakash, Haseler, Claire A., van Elk, René, Smit, August B., Gallagher, Timothy, Sixma, Titia K.
Publicado 2012

Sharp kinking of a coiled-coil in MutS allows DNA binding and release

por Bhairosing-Kok, Doreth, Groothuizen, Flora S, Fish, Alexander, Dharadhar, Shreya, Winterwerp, Herrie H K, Sixma, Titia K
Publicado 2019

Proteomic analysis identifies novel binding partners of BAP1

por Baas, Roy, J. van der Wal, Fenna, Bleijerveld, Onno B., van Attikum, Haico, Sixma, Titia K.
Publicado 2021

Magnesium Coordination Controls the Molecular Switch Function of DNA Mismatch Repair Protein MutS

por Lebbink, Joyce H. G., Fish, Alexander, Reumer, Annet, Natrajan, Ganesh, Winterwerp, Herrie H. K., Sixma, Titia K.
Publicado 2010

Target Specificity of the E3 Ligase LUBAC for Ubiquitin and NEMO Relies on Different Minimal Requirements

por Smit, Judith J., van Dijk, Willem J., El Atmioui, Dris, Merkx, Remco, Ovaa, Huib, Sixma, Titia K.
Publicado 2013

Mechanism of UCH-L5 Activation and Inhibition by DEUBAD Domains in RPN13 and INO80G

por Sahtoe, Danny D., van Dijk, Willem J., El Oualid, Farid, Ekkebus, Reggy, Ovaa, Huib, Sixma, Titia K.
Publicado 2015

Functional characterization of Rad18 domains for Rad6, ubiquitin, DNA binding and PCNA modification

por Notenboom, Valerie, Hibbert, Richard G., van Rossum-Fikkert, Sarah E., Olsen, Jesper V., Mann, Matthias, Sixma, Titia K.
Publicado 2007

Ubiquitin-specific protease 4 is inhibited by its ubiquitin-like domain

por Luna-Vargas, Mark P A, Faesen, Alex C, van Dijk, Willem J, Rape, Michael, Fish, Alexander, Sixma, Titia K
Publicado 2011

USP48 restrains resection by site-specific cleavage of the BRCA1 ubiquitin mark from H2A

por Uckelmann, Michael, Densham, Ruth M., Baas, Roy, Winterwerp, Herrie H. K., Fish, Alexander, Sixma, Titia K., Morris, Joanna R.
Publicado 2018

Structural analysis of the LDL receptor–interacting FERM domain in the E3 ubiquitin ligase IDOL reveals an obscured substrate-binding site

por Martinelli, Luca, Adamopoulos, Athanassios, Johansson, Patrik, Wan, Paul T., Gunnarsson, Jenny, Guo, Hongwei, Boyd, Helen, Zelcer, Noam, Sixma, Titia K.
Publicado 2020

The E3 ligase HOIP specifies linear ubiquitin chain assembly through its RING-IBR-RING domain and the unique LDD extension

por Smit, Judith J, Monteferrario, Davide, Noordermeer, Sylvie M, van Dijk, Willem J, van der Reijden, Bert A, Sixma, Titia K
Publicado 2012