Pharmacokinetics and Pharmacodynamics with Extended Dosing of CC-486 in Patients with Hematologic Malignancies

por Laille, Eric, Shi, Tao, Garcia-Manero, Guillermo, Cogle, Christopher R., Gore, Steven D., Hetzer, Joel, Kumar, Keshava, Skikne, Barry, MacBeth, Kyle J.
Publicado 2015

Design and rationale of the QUAZAR Lower-Risk MDS (AZA-MDS-003) trial: a randomized phase 3 study of CC-486 (oral azacitidine) plus best supportive care vs placebo plus best suppor...

por Garcia-Manero, Guillermo, Almeida, Antonio, Giagounidis, Aristoteles, Platzbecker, Uwe, Garcia, Regina, Voso, Maria Teresa, Larsen, Stephen R., Valcarcel, David, Silverman, Lewis R., Skikne, Barry, Santini, Valeria
Publicado 2016

Extended dosing with CC‐486 (oral azacitidine) in patients with myeloid malignancies

por Savona, Michael R., Kolibaba, Kathryn, Conkling, Paul, Kingsley, Edwin C., Becerra, Carlos, Morris, John C., Rifkin, Robert M., Laille, Eric, Kellerman, Amy, Ukrainskyj, Stacey M., Dong, Qian, Skikne, Barry S.
Publicado 2018

Evaluation of the bioequivalence and food effect on the bioavailability of CC-486 (oral azacitidine) tablets in adult patients with cancer

por Babiker, Hani M., Milhem, Mohammed, Aisner, Joseph, Edenfield, William, Shepard, Dale, Savona, Michael, Iyer, Swaminathan, Abdelrahim, Maen, Beach, C. L., Skikne, Barry, Laille, Eric, Tsai, Kao-Tai, Ho, Thai
Publicado 2020

CC-486 Maintenance after Stem Cell Transplantation in Patients with Acute Myeloid Leukemia or Myelodysplastic Syndromes

por de Lima, Marcos, Oran, Betul, Champlin, Richard E., Papadopoulos, Esperanza B., Giralt, Sergio A., Scott, Bart L., William, Basem M., Hetzer, Joel, Laille, Eric, Hubbell, Becky, Skikne, Barry S., Craddock, Charles
Publicado 2018

Survival outcomes with oral azacitidine maintenance in patients with acute myeloid leukemia in remission by receipt of initial chemotherapy: subgroup analyses from the phase III QU...

por Wei, Andrew H., Roboz, Gail J., Dombret, Hervé, Döhner, Hartmut, Schuh, Andre C., Montesinos, Pau, Selleslag, Dominik, Bondarenko, Sergey N., Prebet, Thomas, Lai, Yinzhi, Skikne, Barry, Beach, C.L., Ravandi, Farhad
Publicado 2023

Design of the randomized, Phase III, QUAZAR AML Maintenance trial of CC-486 (oral azacitidine) maintenance therapy in acute myeloid leukemia

por Roboz, Gail J, Montesinos, Pau, Selleslag, Dominik, Wei, Andrew, Jang, Jun-Ho, Falantes, Jose, Voso, Maria T, Sayar, Hamid, Porkka, Kimmo, Marlton, Paula, Almeida, Antonio, Mohan, Sanjay, Ravandi, Farhad, Garcia-Manero, Guillermo, Skikne, Barry, Kantarjian, Hagop
Publicado 2016

P411: LONGITUDINAL CHARACTERIZATION OF MOLECULAR VARIANTS AT REMISSION AND RELAPSE: SUBANALYSIS OF THE QUAZAR AML-001 TRIAL

por Lopes De Menezes, Daniel, Wei, Andrew, Döhner, Hartmut, Roboz, Gail, Teresa Voso, Maria, Schuh, Andre, See, Wendy L., Ugidos, Manuel, Amzallag, Arnaud, Risueño, Alberto, Kyriakopoulos, Charalampos, Nvs Suragani, Rajasekhar, Skikne, Barry, Beach, CL, Prebet, Thomas, Gandhi, Anita
Publicado 2023

P459: DISEASE MONITORING OF NPM1-MUTANT (MUT) ACUTE MYELOID LEUKEMIA (AML) USING MEASURABLE RESIDUAL DISEASE (MRD) ASSESSMENTS DURING ORAL AZACITIDINE (ORAL-AZA) TREATMENT (TX): A...

por Lopes De Menezes, Daniel, Roboz, Gail, Döhner, Hartmut, Wei, Andrew, Teresa Voso, Maria, Schuh, Andre, See, Wendy L., Ugidos, Manuel, Amzallag, Arnaud, Risueño, Alberto, H. Eng, Kevin, Nvs Suragani, Rajasekhar, Skikne, Barry, Beach, CL, Prebet, Thomas, Gandhi, Anita
Publicado 2023

Prognostic impact of NPM1 and FLT3 mutations in patients with AML in first remission treated with oral azacitidine

por Döhner, Hartmut, Wei, Andrew H., Roboz, Gail J., Montesinos, Pau, Thol, Felicitas R., Ravandi, Farhad, Dombret, Hervé, Porkka, Kimmo, Sandhu, Irwindeep, Skikne, Barry, See, Wendy L., Ugidos, Manuel, Risueño, Alberto, Chan, Esther T., Thakurta, Anjan, Beach, C.L., Lopes de Menezes, Daniel
Publicado 2022

Cytogenetics and gene mutations influence survival in older patients with acute myeloid leukemia treated with azacitidine or conventional care

por Döhner, Hartmut, Dolnik, Anna, Tang, Lin, Seymour, John F., Minden, Mark D., Stone, Richard M., del Castillo, Teresa Bernal, Al-Ali, Haifa Kathrin, Santini, Valeria, Vyas, Paresh, Beach, C. L., MacBeth, Kyle J., Skikne, Barry S., Songer, Steve, Tu, Nora, Bullinger, Lars, Dombret, Hervé
Publicado 2018

Clinical characteristics and outcomes according to age in lenalidomide-treated patients with RBC transfusion-dependent lower-risk MDS and del(5q)

por Fenaux, Pierre, Giagounidis, Aristoteles, Selleslag, Dominik, Beyne-Rauzy, Odile, Mittelman, Moshe, Muus, Petra, Nimer, Stephen D., Hellström-Lindberg, Eva, Powell, Bayard L., Guerci-Bresler, Agnes, Sekeres, Mikkael A., Deeg, H. Joachim, del Cañizo, Consuelo, Greenberg, Peter L., Shammo, Jamile M., Skikne, Barry, Yu, Xujie, List, Alan F.
Publicado 2017

Management of adverse events in patients with acute myeloid leukemia in remission receiving oral azacitidine: experience from the phase 3 randomized QUAZAR AML-001 trial

por Ravandi, Farhad, Roboz, Gail J., Wei, Andrew H., Döhner, Hartmut, Pocock, Christopher, Selleslag, Dominik, Montesinos, Pau, Sayar, Hamid, Musso, Maurizio, Figuera-Alvarez, Angela, Safah, Hana, Tse, William, Sohn, Sang Kyun, Hiwase, Devendra, Chevassut, Timothy, Pierdomenico, Francesca, La Torre, Ignazia, Skikne, Barry, Bailey, Rochelle, Zhong, Jianhua, Beach, C. L., Dombret, Herve
Publicado 2021

Oral azacitidine preserves favorable level of fatigue and health-related quality of life for patients with acute myeloid leukemia in remission: results from the phase III, placebo-...

por Roboz, Gail J., Döhner, Hartmut, Pocock, Christopher, Dombret, Hervé, Ravandi, Farhad, Jang, Jun Ho, Selleslag, Dominik, Mayer, Jiří, Martens, Uwe M., Liesveld, Jane, Bernal, Teresa, Wang, Ming Chung, Yu, Peiwen, Shi, Ling, Guo, Shien, La Torre, Ignazia, Skikne, Barry, Dong, Qian, Braverman, Julia, Nehme, Salem Abi, Beach, C. L., Wei, Andrew H.
Publicado 2021

Phase III, Randomized, Placebo-Controlled Trial of CC-486 (Oral Azacitidine) in Patients With Lower-Risk Myelodysplastic Syndromes

por Garcia-Manero, Guillermo, Santini, Valeria, Almeida, Antonio, Platzbecker, Uwe, Jonasova, Anna, Silverman, Lewis R., Falantes, Jose, Reda, Gianluigi, Buccisano, Francesco, Fenaux, Pierre, Buckstein, Rena, Diez Campelo, Maria, Larsen, Stephen, Valcarcel, David, Vyas, Paresh, Giai, Valentina, Olíva, Esther Natalie, Shortt, Jake, Niederwieser, Dietger, Mittelman, Moshe, Fianchi, Luana, La Torre, Ignazia, Zhong, Jianhua, Laille, Eric, Lopes de Menezes, Daniel, Skikne, Barry, Beach, C. L., Giagounidis, Aristoteles
Publicado 2021