AKT-induced reactive oxygen species generate imatinib-resistant clones emerging from chronic myeloid leukemia progenitor cells

por Nieborowska-Skorska, Margaret, Flis, Sylwia, Skorski, Tomasz
Publicado 2014

RAD52 as a Potential Target for Synthetic Lethality-Based Anticancer Therapies

por Toma, Monika, Sullivan-Reed, Katherine, Śliwiński, Tomasz, Skorski, Tomasz
Publicado 2019

Simultaneous Inhibition of BCR-ABL1 Tyrosine Kinase and PAK1/2 Serine/Threonine Kinase Exerts Synergistic Effect against Chronic Myeloid Leukemia Cells

por Flis, Sylwia, Bratek, Ewelina, Chojnacki, Tomasz, Piskorek, Marlena, Skorski, Tomasz
Publicado 2019

Pre-Existing and Acquired Resistance to PARP Inhibitor-Induced Synthetic Lethality

por Le, Bac Viet, Podszywałow-Bartnicka, Paulina, Piwocka, Katarzyna, Skorski, Tomasz
Publicado 2022

Reactive Oxygen Species and Mitochondrial DNA Damage and Repair in BCR-ABL1 Cells Resistant to Imatinib

por Blasiak, Janusz, Hoser, Grazyna, Bialkowska-Warzecha, Jolanta, Pawlowska, Elzbieta, Skorski, Tomasz
Publicado 2015

Synthetic Lethality Targeting Polθ

por Drzewiecka, Małgorzata, Barszczewska-Pietraszek, Gabriela, Czarny, Piotr, Skorski, Tomasz, Śliwiński, Tomasz
Publicado 2022

Polθ Inhibition: An Anticancer Therapy for HR-Deficient Tumours

por Barszczewska-Pietraszek, Gabriela, Drzewiecka, Małgorzata, Czarny, Piotr, Skorski, Tomasz, Śliwiński, Tomasz
Publicado 2022

UV Differentially Induces Oxidative Stress, DNA Damage and Apoptosis in BCR-ABL1-Positive Cells Sensitive and Resistant to Imatinib

por Synowiec, Ewelina, Hoser, Grazyna, Wojcik, Katarzyna, Pawlowska, Elzbieta, Skorski, Tomasz, Błasiak, Janusz
Publicado 2015

Relationship between Oxidative Stress and Imatinib Resistance in Model Chronic Myeloid Leukemia Cells

por Głowacki, Sylwester, Synowiec, Ewelina, Szwed, Marzena, Toma, Monika, Skorski, Tomasz, Śliwiński, Tomasz
Publicado 2021

Doxorubicin Differentially Induces Apoptosis, Expression of Mitochondrial Apoptosis-Related Genes, and Mitochondrial Potential in BCR-ABL1-Expressing Cells Sensitive and Resistant...

por Synowiec, Ewelina, Hoser, Grazyna, Bialkowska-Warzecha, Jolanta, Pawlowska, Elzbieta, Skorski, Tomasz, Blasiak, Janusz
Publicado 2015

Signal Transducer and Activator of  Transcription (STAT)5 Activation by BCR/ABL Is Dependent on Intact Src Homology (SH)3 and SH2 Domains of BCR/ABL and Is Required for Leukemogene...

por Nieborowska-Skorska, Malgorzata, Wasik, Mariusz A., Slupianek, Artur, Salomoni, Paolo, Kitamura, Toshio, Calabretta, Bruno, Skorski, Tomasz
Publicado 1999

Expression of Constitutively Active Raf-1 in the Mitochondria Restores Antiapoptotic and Leukemogenic Potential of a Transformation-deficient BCR/ABL Mutant

por Salomoni, Paolo, Wasik, Mariusz A., Riedel, Richard F., Reiss, Krzysztof, Choi, John K., Skorski, Tomasz, Calabretta, Bruno
Publicado 1998

Monoubiquitinated Fanconi Anemia D2 (FANCD2-Ub) Is Required for BCR-ABL1 Kinase -Induced Leukemogenesis

por Koptyra, Mateusz, Stoklosa, Tomasz, Hoser, Grazyna, Glodkowska-Mrowka, Eliza, Seferynska, Ilona, Klejman, Agata, Blasiak, Janusz, Skorski, Tomasz
Publicado 2011

Gadd45a deficiency accelerates BCR-ABL driven chronic myelogenous leukemia

por Mukherjee, Kaushiki, Sha, Xiaojin, Magimaidas, Andrew, Maifrede, Silvia, Skorski, Tomasz, Bhatia, Ravi, Hoffman, Barbara, Liebermann, Dan A.
Publicado 2017

Identification of a Small Molecule Inhibitor of RAD52 by Structure-Based Selection

por Sullivan, Katherine, Cramer-Morales, Kimberly, McElroy, Daniel L., Ostrov, David A., Haas, Kimberly, Childers, Wayne, Hromas, Robert, Skorski, Tomasz
Publicado 2016

Class I HDAC Inhibition Leads to a Downregulation of FANCD2 and RAD51, and the Eradication of Glioblastoma Cells

por Drzewiecka, Małgorzata, Jaśniak, Dominika, Barszczewska-Pietraszek, Gabriela, Czarny, Piotr, Kobrzycka, Anna, Wieczorek, Marek, Radek, Maciej, Szemraj, Janusz, Skorski, Tomasz, Śliwiński, Tomasz
Publicado 2023

ABL1 kinase as a tumor suppressor in AML1-ETO and NUP98-PMX1 leukemias

por Golovine, Konstantin, Abalakov, Gleb, Lian, Zhaorui, Chatla, Srinivas, Karami, Adam, Chitrala, Kumaraswamy Naidu, Madzo, Jozef, Nieborowska-Skorska, Margaret, Huang, Jian, Skorski, Tomasz
Publicado 2023

Poly(ADP-ribose) Polymerase 1, PARP1, modifies EZH2 and inhibits EZH2 histone methyltransferase activity after DNA damage

por Caruso, Lisa B., Martin, Kayla A., Lauretti, Elisabetta, Hulse, Michael, Siciliano, Micheal, Lupey-Green, Lena N., Abraham, Aaron, Skorski, Tomasz, Tempera, Italo
Publicado 2018

Increased phosphorylation of eIF2α in chronic myeloid leukemia cells stimulates secretion of matrix modifying enzymes

por Podszywalow-Bartnicka, Paulina, Cmoch, Anna, Wolczyk, Magdalena, Bugajski, Lukasz, Tkaczyk, Marta, Dadlez, Michal, Nieborowska-Skorska, Margaret, Koromilas, Antonis E., Skorski, Tomasz, Piwocka, Katarzyna
Publicado 2016

Histone Deacetylases (HDAC) Inhibitor—Valproic Acid Sensitizes Human Melanoma Cells to Dacarbazine and PARP Inhibitor

por Drzewiecka, Małgorzata, Gajos-Michniewicz, Anna, Hoser, Grażyna, Jaśniak, Dominika, Barszczewska-Pietraszek, Gabriela, Sitarek, Przemysław, Czarny, Piotr, Piekarski, Janusz, Radek, Maciej, Czyż, Małgorzata, Skorski, Tomasz, Śliwiński, Tomasz
Publicado 2023