Deciphering the molecular effects of romidepsin on germ cell tumours: DHRS2 is involved in cell cycle arrest but not apoptosis or induction of romidepsin effectors

por Nettersheim, Daniel, Berger, Daniel, Jostes, Sina, Skowron, Margaretha, Schorle, Hubert
Publicado 2018

Molecular and epigenetic pathogenesis of germ cell tumors

por Müller, Melanie R., Skowron, Margaretha A., Albers, Peter, Nettersheim, Daniel
Publicado 2021

Various Mechanisms Involve the Nuclear Factor (Erythroid-Derived 2)-Like (NRF2) to Achieve Cytoprotection in Long-Term Cisplatin-Treated Urothelial Carcinoma Cell Lines

por Skowron, Margaretha A., Niegisch, Günter, Albrecht, Philipp, van Koeveringe, Gommert, Romano, Andrea, Albers, Peter, Schulz, Wolfgang A., Hoffmann, Michèle J.
Publicado 2017

Distinct mechanisms contribute to acquired cisplatin resistance of urothelial carcinoma cells

por Höhn, Annika, Krüger, Katharina, Skowron, Margaretha A., Bormann, Stefanie, Schumacher, Lena, Schulz, Wolfgang A., Hoffmann, Michèle J., Niegisch, Günter, Fritz, Gerhard
Publicado 2016

The New Immortalized Uroepithelial Cell Line HBLAK Contains Defined Genetic Aberrations Typical of Early Stage Urothelial Tumors

por Hoffmann, Michèle J., Koutsogiannouli, Evangelia, Skowron, Margaretha A., Pinkerneil, Maria, Niegisch, Günter, Brandt, Artur, Stepanow, Stefanie, Rieder, Harald, Schulz, Wolfgang A.
Publicado 2016

Therapeutical interference with the epigenetic landscape of germ cell tumors: a comparative drug study and new mechanistical insights

por Müller, Melanie R., Burmeister, Aaron, Skowron, Margaretha A., Stephan, Alexa, Bremmer, Felix, Wakileh, Gamal A., Petzsch, Patrick, Köhrer, Karl, Albers, Peter, Nettersheim, Daniel
Publicado 2022

Phenotype plasticity rather than repopulation from CD90/CK14+ cancer stem cells leads to cisplatin resistance of urothelial carcinoma cell lines

por Skowron, Margaretha A., Niegisch, Günter, Fritz, Gerhard, Arent, Tanja, van Roermund, Joep G. H., Romano, Andrea, Albers, Peter, Schulz, Wolfgang A., Hoffmann, Michèle J.
Publicado 2015

Multifaceted Mechanisms of Cisplatin Resistance in Long-Term Treated Urothelial Carcinoma Cell Lines

por Skowron, Margaretha A., Melnikova, Margarita, van Roermund, Joep G. H., Romano, Andrea, Albers, Peter, Thomale, Jürgen, Schulz, Wolfgang A., Niegisch, Günter, Hoffmann, Michèle J.
Publicado 2018

CDK4/6 inhibition presents as a therapeutic option for paediatric and adult germ cell tumours and induces cell cycle arrest and apoptosis via canonical and non-canonical mechanisms

por Skowron, Margaretha A., Vermeulen, Marieke, Winkelhausen, Anna, Becker, Teresa K., Bremmer, Felix, Petzsch, Patrick, Schönberger, Stefan, Calaminus, Gabriele, Köhrer, Karl, Albers, Peter, Nettersheim, Daniel
Publicado 2020

Molecular characterization of the CXCR4 / CXCR7 axis in germ cell tumors and its targetability using nanobody-drug-conjugates

por Wakileh, Gamal A., Bierholz, Philipp, Kotthoff, Mara, Skowron, Margaretha A., Bremmer, Felix, Stephan, Alexa, Anbuhl, Stephanie M., Heukers, Raimond, Smit, Martine J., Ströbel, Philipp, Nettersheim, Daniel
Publicado 2023

Distinctive mutational spectrum and karyotype disruption in long-term cisplatin-treated urothelial carcinoma cell lines

por Skowron, Margaretha A., Petzsch, Patrick, Hardt, Karin, Wagner, Nicholas, Beier, Manfred, Stepanow, Stefanie, Drechsler, Matthias, Rieder, Harald, Köhrer, Karl, Niegisch, Günter, Hoffmann, Michèle J., Schulz, Wolfgang A.
Publicado 2019

The pioneer and differentiation factor FOXA2 is a key driver of yolk‐sac tumour formation and a new biomarker for paediatric and adult yolk‐sac tumours

por Wruck, Wasco, Bremmer, Felix, Kotthoff, Mara, Fichtner, Alexander, Skowron, Margaretha A., Schönberger, Stefan, Calaminus, Gabriele, Vokuhl, Christian, Pfister, David, Heidenreich, Axel, Albers, Peter, Adjaye, James, Nettersheim, Daniel
Publicado 2021

Targeting CLDN6 in germ cell tumors by an antibody-drug-conjugate and studying therapy resistance of yolk-sac tumors to identify and screen specific therapeutic options

por Skowron, Margaretha A., Kotthoff, Mara, Bremmer, Felix, Ruhnke, Katja, Parmaksiz, Fatma, Richter, Annika, Küffer, Stefan, Reuter-Jessen, Kirsten, Pauls, Stella, Stefanski, Anja, Ströbel, Philipp, Stühler, Kai, Nettersheim, Daniel
Publicado 2023

ARID1A Regulates Transcription and the Epigenetic Landscape via POLE and DMAP1 While ARID1A Deficiency or Pharmacological Inhibition Sensitizes Germ Cell Tumor Cells to ATR Inhibit...

por Kurz, Lukas, Miklyaeva, Alissa, Skowron, Margaretha A., Overbeck, Nina, Poschmann, Gereon, Becker, Teresa, Eul, Katharina, Kurz, Thomas, Schönberger, Stefan, Calaminus, Gabriele, Stühler, Kai, Dykhuizen, Emily, Albers, Peter, Nettersheim, Daniel
Publicado 2020

Characterizing the mutational burden, DNA methylation landscape, and proteome of germ cell tumor-related somatic-type malignancies to identify the tissue-of-origin, mechanisms of t...

por Bremmer, Felix, Pongratanakul, Pailin, Skowron, Margaretha, Che, Yue, Richter, Annika, Küffer, Stefan, Reuter-Jessen, Kirsten, Bohnenberger, Hanibal, Pauls, Stella, Kresbach, Catena, Schüller, Ulrich, Stühler, Kai, Ströbel, Philipp, Albers, Peter, Nettersheim, Daniel
Publicado 2023

Prodigiosin Sensitizes Sensitive and Resistant Urothelial Carcinoma Cells to Cisplatin Treatment

por Berning, Lena, Schlütermann, David, Friedrich, Annabelle, Berleth, Niklas, Sun, Yadong, Wu, Wenxian, Mendiburo, María José, Deitersen, Jana, Brass, Hannah U. C., Skowron, Margaretha A., Hoffmann, Michèle J., Niegisch, Günter, Pietruszka, Jörg, Stork, Björn
Publicado 2021

Establishment and Evaluation of Dual HDAC/BET Inhibitors as Therapeutic Options for Germ Cell Tumors and Other Urological Malignancies

por Burmeister, Aaron, Stephan, Alexa, Alves Avelar, Leandro A., Müller, Melanie R., Seiwert, Andrea, Höfmann, Stefan, Fischer, Fabian, Torres-Gomez, Hector, Hoffmann, Michèle J., Niegisch, Guenter, Bremmer, Felix, Petzsch, Patrick, Köhrer, Karl, Albers, Peter, Kurz, Thomas, Skowron, Margaretha A., Nettersheim, Daniel
Publicado 2022

The signal transducer CD24 suppresses the germ cell program and promotes an ectodermal rather than mesodermal cell fate in embryonal carcinomas

por Skowron, Margaretha A., Becker, Teresa K., Kurz, Lukas, Jostes, Sina, Bremmer, Felix, Fronhoffs, Florian, Funke, Kai, Wakileh, Gamal A., Müller, Melanie R., Burmeister, Aaron, Lenz, Thomas, Stefanski, Anja, Stühler, Kai, Petzsch, Patrick, Köhrer, Karl, Altevogt, Peter, Albers, Peter, Kristiansen, Glen, Schorle, Hubert, Nettersheim, Daniel
Publicado 2021

Profiling the 3D interaction between germ cell tumors and microenvironmental cells at the transcriptome and secretome level

por Skowron, Margaretha A., Eul, Katharina, Stephan, Alexa, Ludwig, Gillian F., Wakileh, Gamal A., Bister, Arthur, Söhngen, Christian, Raba, Katharina, Petzsch, Patrick, Poschmann, Gereon, Kuffour, Edmund Osei, Degrandi, Daniel, Ali, Shafaqat, Wiek, Constanze, Hanenberg, Helmut, Münk, Carsten, Stühler, Kai, Köhrer, Karl, Mass, Elvira, Nettersheim, Daniel
Publicado 2022