Secondary phenotype analysis in ascertained family designs: application to the Leiden longevity study

por Tissier, Renaud, Tsonaka, Roula, Mooijaart, Simon P., Slagboom, Eline, Houwing‐Duistermaat, Jeanine J.
Publicado 2017

Improved selection of participants in genetic longevity studies: family scores revisited

por Rodríguez-Girondo, Mar, van den Berg, Niels, Hof, Michel H., Beekman, Marian, Slagboom, Eline
Publicado 2021

Lower proportion of naïve peripheral CD8+ T cells and an unopposed pro-inflammatory response to human Cytomegalovirus proteins in vitro are associated with longer survival in very...

por Derhovanessian, Evelyna, Maier, Andrea B., Hähnel, Karin, Zelba, Henning, de Craen, Anton J. M., Roelofs, Helene, Slagboom, Eline P., Westendorp, Rudi G. J., Pawelec, Graham
Publicado 2012

C-reactive protein and glucose regulation in familial longevity

por Rozing, Maarten P., Mooijaart, Simon P., Beekman, Marian, Wijsman, Carolien A., Maier, Andrea B., Bartke, Andrzej, Westendorp, Rudi G.J., Slagboom, Eline P., van Heemst, Diana
Publicado 2011

Associations between insulin action and integrity of brain microstructure differ with familial longevity and with age

por Akintola, Abimbola A., van den Berg, Annette, van Buchem, Mark A., Jansen, Steffy W., Slagboom, Eline P., Westendorp, Rudi G., van der Grond, Jeroen, van Heemst, Diana
Publicado 2015

Polymorphisms associated with type 2 diabetes in familial longevity: The Leiden Longevity Study

por Mooijaart, Simon P., van Heemst, Diana, Noordam, Raymond, Rozing, Maarten P., Wijsman, Carolien A., de Craen, Anton J.M., Westendorp, Rudi G.J., Beekman, Marian, Slagboom, Eline P.
Publicado 2010

Lipidomics of familial longevity

por Gonzalez-Covarrubias, Vanessa, Beekman, Marian, Uh, Hae-Won, Dane, Adrie, Troost, Jorne, Paliukhovich, Iryna, Kloet, Frans M, Houwing-Duistermaat, Jeanine, Vreeken, Rob J, Hankemeier, Thomas, Slagboom, Eline P
Publicado 2013

Mobster: accurate detection of mobile element insertions in next generation sequencing data

por Thung, Djie Tjwan, de Ligt, Joep, Vissers, Lisenka EM, Steehouwer, Marloes, Kroon, Mark, de Vries, Petra, Slagboom, Eline P, Ye, Kai, Veltman, Joris A, Hehir-Kwa, Jayne Y
Publicado 2014

Broad phenotype of cysteine-altering NOTCH3 variants in UK Biobank: CADASIL to nonpenetrance

por Rutten, Julie W., Hack, Remco J., Duering, Marco, Gravesteijn, Gido, Dauwerse, Johannes G., Overzier, Maurice, van den Akker, Erik B., Slagboom, Eline, Holstege, Henne, Nho, Kwangsik, Saykin, Andrew, Dichgans, Martin, Malik, Rainer, Lesnik Oberstein, Saskia A.J.
Publicado 2020

Systematic Evaluation of Normalization Methods for Glycomics Data Based on Performance of Network Inference

por Benedetti, Elisa, Gerstner, Nathalie, Pučić-Baković, Maja, Keser, Toma, Reiding, Karli R., Ruhaak, L. Renee, Štambuk, Tamara, Selman, Maurice H.J., Rudan, Igor, Polašek, Ozren, Hayward, Caroline, Beekman, Marian, Slagboom, Eline, Wuhrer, Manfred, Dunlop, Malcolm G., Lauc, Gordan, Krumsiek, Jan
Publicado 2020

Common genetic variation in the Estrogen Receptor Beta (ESR2) gene and osteoarthritis: results of a meta-analysis

por Kerkhof, Hanneke JM, Meulenbelt, Ingrid, Carr, Andrew, Gonzalez, Antonio, Hart, Deborah, Hofman, Albert, Kloppenburg, Margreet, Lane, Nancy E, Loughlin, John, Nevitt, Michael C, Pols, Huibert AP, Rivadeneira, Fernando, Slagboom, Eline P, Spector, Tim D, Stolk, Lisette, Tsezou, Aspasia, Uitterlinden, André G, Valdes, Ana M, van Meurs, Joyce BJ
Publicado 2010

Annotating Transcriptional Effects of Genetic Variants in Disease‐Relevant Tissue: Transcriptome‐Wide Allelic Imbalance in Osteoarthritic Cartilage

por den Hollander, Wouter, Pulyakhina, Irina, Boer, Cindy, Bomer, Nils, van der Breggen, Ruud, Arindrarto, Wibowo, Couthino de Almeida, Rodrigo, Lakenberg, Nico, Sentner, Thom, Laros, Jeroen F. J., ‘t Hoen, Peter A. C., Slagboom, Eline P. E., Nelissen, Rob G. H. H., van Meurs, Joyce, Ramos, Yolande F. M., Meulenbelt, Ingrid
Publicado 2019

Metabolomic profiles predict individual multidisease outcomes

por Buergel, Thore, Steinfeldt, Jakob, Ruyoga, Greg, Pietzner, Maik, Bizzarri, Daniele, Vojinovic, Dina, Upmeier zu Belzen, Julius, Loock, Lukas, Kittner, Paul, Christmann, Lara, Hollmann, Noah, Strangalies, Henrik, Braunger, Jana M., Wild, Benjamin, Chiesa, Scott T., Spranger, Joachim, Klostermann, Fabian, van den Akker, Erik B., Trompet, Stella, Mooijaart, Simon P., Sattar, Naveed, Jukema, J. Wouter, Lavrijssen, Birgit, Kavousi, Maryam, Ghanbari, Mohsen, Ikram, Mohammad A., Slagboom, Eline, Kivimaki, Mika, Langenberg, Claudia, Deanfield, John, Eils, Roland, Landmesser, Ulf
Publicado 2022

Circulating cell-free DNA in health and disease — the relationship to health behaviours, ageing phenotypes and metabolomics

por Kananen, Laura, Hurme, Mikko, Bürkle, Alexander, Moreno-Villanueva, Maria, Bernhardt, Jürgen, Debacq-Chainiaux, Florence, Grubeck-Loebenstein, Beatrix, Malavolta, Marco, Basso, Andrea, Piacenza, Francesco, Collino, Sebastiano, Gonos, Efstathios S., Sikora, Ewa, Gradinaru, Daniela, Jansen, Eugene H. J. M., Dollé, Martijn E. T., Salmon, Michel, Stuetz, Wolfgang, Weber, Daniela, Grune, Tilman, Breusing, Nicolle, Simm, Andreas, Capri, Miriam, Franceschi, Claudio, Slagboom, Eline, Talbot, Duncan, Libert, Claude, Raitanen, Jani, Koskinen, Seppo, Härkänen, Tommi, Stenholm, Sari, Ala-Korpela, Mika, Lehtimäki, Terho, Raitakari, Olli T., Ukkola, Olavi, Kähönen, Mika, Jylhä, Marja, Jylhävä, Juulia
Publicado 2022

Sex Differences in Genetic Associations With Longevity

por Zeng, Yi, Nie, Chao, Min, Junxia, Chen, Huashuai, Liu, Xiaomin, Ye, Rui, Chen, Zhihua, Bai, Chen, Xie, Enjun, Yin, Zhaoxue, Lv, Yuebin, Lu, Jiehua, Li, Jianxin, Ni, Ting, Bolund, Lars, Land, Kenneth C., Yashin, Anatoliy, O’Rand, Angela M., Sun, Liang, Yang, Ze, Tao, Wei, Gurinovich, Anastasia, Franceschi, Claudio, Xie, Jichun, Gu, Jun, Hou, Yong, Liu, Xiao, Xu, Xun, Robine, Jean-Marie, Deelen, Joris, Sebastiani, Paola, Slagboom, Eline, Perls, Thomas, Hauser, Elizabeth, Gottschalk, William, Tan, Qihua, Christensen, Kaare, Shi, Xiaoming, Lutz, Mike, Tian, Xiao-Li, Yang, Huanming, Vaupel, James
Publicado 2018

Novel Genetic Variants for Cartilage Thickness and Hip Osteoarthritis

por Castaño-Betancourt, Martha C., Evans, Dan S., Ramos, Yolande F. M., Boer, Cindy G., Metrustry, Sarah, Liu, Youfang, den Hollander, Wouter, van Rooij, Jeroen, Kraus, Virginia B., Yau, Michelle S., Mitchell, Braxton D., Muir, Kenneth, Hofman, Albert, Doherty, Michael, Doherty, Sally, Zhang, Weiya, Kraaij, Robert, Rivadeneira, Fernando, Barrett-Connor, Elizabeth, Maciewicz, Rose A., Arden, Nigel, Nelissen, Rob G. H. H., Kloppenburg, Margreet, Jordan, Joanne M., Nevitt, Michael C., Slagboom, Eline P., Hart, Deborah J., Lafeber, Floris, Styrkarsdottir, Unnur, Zeggini, Eleftheria, Evangelou, Evangelos, Spector, Tim D., Uitterlinden, Andre G., Lane, Nancy E., Meulenbelt, Ingrid, Valdes, Ana M., van Meurs, Joyce B. J.
Publicado 2016

Novel loci and pathways significantly associated with longevity

por Zeng, Yi, Nie, Chao, Min, Junxia, Liu, Xiaomin, Li, Mengmeng, Chen, Huashuai, Xu, Hanshi, Wang, Mingbang, Ni, Ting, Li, Yang, Yan, Han, Zhang, Jin-Pei, Song, Chun, Chi, Li-Qing, Wang, Han-Ming, Dong, Jie, Zheng, Gu-Yan, Lin, Li, Qian, Feng, Qi, Yanwei, Liu, Xiao, Cao, Hongzhi, Wang, Yinghao, Zhang, Lijuan, Li, Zhaochun, Zhou, Yufeng, Wang, Yan, Lu, Jiehua, Li, Jianxin, Qi, Ming, Bolund, Lars, Yashin, Anatoliy, Land, Kenneth C., Gregory, Simon, Yang, Ze, Gottschalk, William, Tao, Wei, Wang, Jian, Wang, Jun, Xu, Xun, Bae, Harold, Nygaard, Marianne, Christiansen, Lene, Christensen, Kaare, Franceschi, Claudio, Lutz, Michael W., Gu, Jun, Tan, Qihua, Perls, Thomas, Sebastiani, Paola, Deelen, Joris, Slagboom, Eline, Hauser, Elizabeth, Xu, Huji, Tian, Xiao-Li, Yang, Huanming, Vaupel, James W.
Publicado 2016

Glycosylation of immunoglobulin G is regulated by a large network of genes pleiotropic with inflammatory diseases

por Klarić, Lucija, Tsepilov, Yakov A., Stanton, Chloe M., Mangino, Massimo, Sikka, Timo Tõnis, Esko, Tõnu, Pakhomov, Eugene, Salo, Perttu, Deelen, Joris, McGurnaghan, Stuart J., Keser, Toma, Vučković, Frano, Ugrina, Ivo, Krištić, Jasminka, Gudelj, Ivan, Štambuk, Jerko, Plomp, Rosina, Pučić-Baković, Maja, Pavić, Tamara, Vilaj, Marija, Trbojević-Akmačić, Irena, Drake, Camilla, Dobrinić, Paula, Mlinarec, Jelena, Jelušić, Barbara, Richmond, Anne, Timofeeva, Maria, Grishchenko, Alexander K., Dmitrieva, Julia, Bermingham, Mairead L., Sharapov, Sodbo Zh., Farrington, Susan M., Theodoratou, Evropi, Uh, Hae-Won, Beekman, Marian, Slagboom, Eline P., Louis, Edouard, Georges, Michel, Wuhrer, Manfred, Colhoun, Helen M., Dunlop, Malcolm G., Perola, Markus, Fischer, Krista, Polasek, Ozren, Campbell, Harry, Rudan, Igor, Wilson, James F., Zoldoš, Vlatka, Vitart, Veronique, Spector, Tim, Aulchenko, Yurii S., Lauc, Gordan, Hayward, Caroline
Publicado 2020

Relationship between genome and epigenome - challenges and requirements for future research

por Almouzni, Geneviève, Altucci, Lucia, Amati, Bruno, Ashley, Neil, Baulcombe, David, Beaujean, Nathalie, Bock, Christoph, Bongcam-Rudloff, Erik, Bousquet, Jean, Braun, Sigurd, Paillerets, Brigitte Bressac-de, Bussemakers, Marion, Clarke, Laura, Conesa, Ana, Estivill, Xavier, Fazeli, Alireza, Grgurević, Neža, Gut, Ivo, Heijmans, Bastiaan T, Hermouet, Sylvie, Houwing–Duistermaat, Jeanine, Iacobucci, Ilaria, Ilaš, Janez, Kandimalla, Raju, Krauss-Etschmann, Susanne, Lasko, Paul, Lehmann, Sören, Lindroth, Anders, Majdič, Gregor, Marcotte, Eric, Martinelli, Giovanni, Martinet, Nadine, Meyer, Eric, Miceli, Cristina, Mills, Ken, Moreno-Villanueva, Maria, Morvan, Ghislaine, Nickel, Dörthe, Niesler, Beate, Nowacki, Mariusz, Nowak, Jacek, Ossowski, Stephan, Pelizzola, Mattia, Pochet, Roland, Potočnik, Uroš, Radwanska, Magdalena, Raes, Jeroen, Rattray, Magnus, Robinson, Mark D, Roelen, Bernard, Sauer, Sascha, Schinzer, Dieter, Slagboom, Eline, Spector, Tim, Stunnenberg, Hendrik G, Tiligada, Ekaterini, Torres-Padilla, Maria-Elena, Tsonaka, Roula, Soom, Ann Van, Vidaković, Melita, Widschwendter, Martin
Publicado 2014

The Genome of the Netherlands: design, and project goals

por Boomsma, Dorret I, Wijmenga, Cisca, Slagboom, Eline P, Swertz, Morris A, Karssen, Lennart C, Abdellaoui, Abdel, Ye, Kai, Guryev, Victor, Vermaat, Martijn, van Dijk, Freerk, Francioli, Laurent C, Hottenga, Jouke Jan, Laros, Jeroen F J, Li, Qibin, Li, Yingrui, Cao, Hongzhi, Chen, Ruoyan, Du, Yuanping, Li, Ning, Cao, Sujie, van Setten, Jessica, Menelaou, Androniki, Pulit, Sara L, Hehir-Kwa, Jayne Y, Beekman, Marian, Elbers, Clara C, Byelas, Heorhiy, de Craen, Anton J M, Deelen, Patrick, Dijkstra, Martijn, den Dunnen, Johan T, de Knijff, Peter, Houwing-Duistermaat, Jeanine, Koval, Vyacheslav, Estrada, Karol, Hofman, Albert, Kanterakis, Alexandros, Enckevort, David van, Mai, Hailiang, Kattenberg, Mathijs, van Leeuwen, Elisabeth M, Neerincx, Pieter B T, Oostra, Ben, Rivadeneira, Fernanodo, Suchiman, Eka H D, Uitterlinden, Andre G, Willemsen, Gonneke, Wolffenbuttel, Bruce H, Wang, Jun, de Bakker, Paul I W, van Ommen, Gert-Jan, van Duijn, Cornelia M
Publicado 2014