Synthesis and Pharmacological Evaluation of Fluorinated Quinoxaline‐Based κ‐Opioid Receptor (KOR) Agonists Designed for PET Studies

por Tangherlini, Giovanni, Börgel, Frederik, Schepmann, Dirk, Slocum, Samuel, Che, Tao, Wagner, Stefan, Schwegmann, Katrin, Hermann, Sven, Mykicki, Nadine, Loser, Karin, Wünsch, Bernhard
Publicado 2020

“TRUPATH, an Open-Source Biosensor Platform for Interrogating the GPCR Transducerome”

por Olsen, Reid H.J., DiBerto, Jeffrey F., English, Justin G., Glaudin, Alexis M., Krumm, Brian E., Slocum, Samuel T., Che, Tao, Gavin, Ariana C., McCorvy, John D., Roth, Bryan L., Strachan, Ryan T.
Publicado 2020

HypoRiPPAtlas as an Atlas of hypothetical natural products for mass spectrometry database search

por Lee, Yi-Yuan, Guler, Mustafa, Chigumba, Desnor N., Wang, Shen, Mittal, Neel, Miller, Cameron, Krummenacher, Benjamin, Liu, Haodong, Cao, Liu, Kannan, Aditya, Narayan, Keshav, Slocum, Samuel T., Roth, Bryan L., Gurevich, Alexey, Behsaz, Bahar, Kersten, Roland D., Mohimani, Hosein
Publicado 2023

Virtual discovery of melatonin receptor ligands to modulate circadian rhythms

por Stein, Reed M., Kang, Hye Jin, McCorvy, John D., Glatfelter, Grant C., Jones, Anthony J., Che, Tao, Slocum, Samuel, Huang, Xi-Ping, Savych, Olena, Moroz, Yurii S., Stauch, Benjamin, Johansson, Linda C., Cherezov, Vadim, Kenakin, Terry, Irwin, John J., Shoichet, Brian K., Roth, Bryan L., Dubocovich, Margarita L.
Publicado 2020

DREADD Agonist 21 Is an Effective Agonist for Muscarinic-Based DREADDs in Vitro and in Vivo

por Thompson, Karen J., Khajehali, Elham, Bradley, Sophie J., Navarrete, Jovana S., Huang, Xi Ping, Slocum, Samuel, Jin, Jian, Liu, Jing, Xiong, Yan, Olsen, Reid H. J., Diberto, Jeffrey F., Boyt, Kristen M., Pina, Melanie M., Pati, Dipanwita, Molloy, Colin, Bundgaard, Christoffer, Sexton, Patrick M., Kash, Thomas L., Krashes, Michael J., Christopoulos, Arthur, Roth, Bryan L., Tobin, Andrew B.
Publicado 2018

XFEL structures of the human MT(2) melatonin receptor reveal basis of subtype selectivity

por Johansson, Linda C., Stauch, Benjamin, McCorvy, John D., Han, Gye Won, Patel, Nilkanth, Huang, Xi-Ping, Batyuk, Alexander, Gati, Cornelius, Slocum, Samuel T., Li, Chufeng, Grandner, Jessica M., Hao, Shuming, Olsen, Reid H.J., Tribo, Alexandra R., Zaare, Sahba, Zhu, Lan, Zatsepin, Nadia A., Weierstall, Uwe, Yous, Saïd, Stevens, Raymond C., Liu, Wei, Roth, Bryan L., Katritch, Vsevolod, Cherezov, Vadim
Publicado 2019

Controlling opioid receptor functional selectivity by targeting distinct subpockets of the orthosteric site

por Uprety, Rajendra, Che, Tao, Zaidi, Saheem A, Grinnell, Steven G, Varga, Balázs R, Faouzi, Abdelfattah, Slocum, Samuel T, Allaoa, Abdullah, Varadi, András, Nelson, Melissa, Bernhard, Sarah M, Kulko, Elizaveta, Le Rouzic, Valerie, Eans, Shainnel O, Simons, Chloe A, Hunkele, Amanda, Subrath, Joan, Pan, Ying Xian, Javitch, Jonathan A, McLaughlin, Jay P, Roth, Bryan L, Pasternak, Gavril W, Katritch, Vsevolod, Majumdar, Susruta
Publicado 2021

Structural basis for ligand recognition at the human MT(1) melatonin receptor

por Stauch, Benjamin, Johansson, Linda C., McCorvy, John D., Patel, Nilkanth, Han, Gye Won, Huang, Xi-Ping, Gati, Cornelius, Batyuk, Alexander, Slocum, Samuel T., Ishchenko, Andrii, Brehm, Wolfgang, White, Thomas A., Michaelian, Nairie, Madsen, Caleb, Zhu, Lan, Grant, Thomas D., Grandner, Jessica M., Shiriaeva, Anna, Olsen, Reid H.J., Tribo, Alexandra R., Yous, Saïd, Stevens, Raymond C., Weierstall, Uwe, Katritch, Vsevolod, Roth, Bryan L., Liu, Wei, Cherezov, Vadim
Publicado 2019