The dinitrobenzamide mustard prodrugs, PR-104A and SN27686, for use in a novel MNDEPT cancer prodrug therapy approach

por Ball, Patrick, Thompson, Emma, Anderson, Simon, Gwenin, Vanessa, Ashoorzadeh, Amir, Smaill, Jeff, Gwenin, Chris
Publicado 2023

Tumour Hypoxia-Mediated Immunosuppression: Mechanisms and Therapeutic Approaches to Improve Cancer Immunotherapy

por Fu, Zhe, Mowday, Alexandra M., Smaill, Jeff B., Hermans, Ian F., Patterson, Adam V.
Publicado 2021

The Flavin Reductase MsuE Is a Novel Nitroreductase that Can Efficiently Activate Two Promising Next-Generation Prodrugs for Gene-Directed Enzyme Prodrug Therapy

por Green, Laura K., Storey, Mathew A., Williams, Elsie M., Patterson, Adam V., Smaill, Jeff B., Copp, Janine N., Ackerley, David F.
Publicado 2013

Tissue Pharmacokinetic Properties and Bystander Potential of Hypoxia-Activated Prodrug CP-506 by Agent-Based Modelling

por Jackson-Patel, Victoria, Liu, Emily, Bull, Matthew R., Ashoorzadeh, Amir, Bogle, Gib, Wolfram, Anna, Hicks, Kevin O., Smaill, Jeff B., Patterson, Adam V.
Publicado 2022

Bioreductive prodrugs as cancer therapeutics: targeting tumor hypoxia

por Guise, Christopher P., Mowday, Alexandra M., Ashoorzadeh, Amir, Yuan, Ran, Lin, Wan-Hua, Wu, Dong-Hai, Smaill, Jeff B., Patterson, Adam V., Ding, Ke
Publicado 2014

Advancing Clostridia to Clinical Trial: Past Lessons and Recent Progress

por Mowday, Alexandra M., Guise, Christopher P., Ackerley, David F., Minton, Nigel P., Lambin, Philippe, Dubois, Ludwig J., Theys, Jan, Smaill, Jeff B., Patterson, Adam V.
Publicado 2016

Design, Synthesis and In-Vitro Biological Evaluation of Antofine and Tylophorine Prodrugs as Hypoxia-Targeted Anticancer Agents

por Omran, Ziad, Guise, Chris P., Chen, Linwei, Rauch, Cyril, Abdalla, Ashraf N., Abdullah, Omeima, Sindi, Ikhlas A., Fischer, Peter M., Smaill, Jeff B., Patterson, Adam V., Liu, Yuxiu, Wang, Qingmin
Publicado 2021

Interrogation of the Structure–Activity Relationship of a Lipophilic Nitroaromatic Prodrug Series Designed for Cancer Gene Therapy Applications

por Ashoorzadeh, Amir, Mowday, Alexandra M., Guise, Christopher P., Silva, Shevan, Bull, Matthew R., Abbattista, Maria R., Copp, Janine N., Williams, Elsie M., Ackerley, David F., Patterson, Adam V., Smaill, Jeff B.
Publicado 2022

Subcellular Location of Tirapazamine Reduction Dramatically Affects Aerobic but Not Anoxic Cytotoxicity

por Guise, Chris P., Abbattista, Maria R., Anderson, Robert F., Li, Dan, Taghipouran, Rana, Tsai, Angela, Lee, Su Jung, Smaill, Jeff B., Denny, William A., Hay, Michael P., Wilson, William R., Hicks, Kevin O., Patterson, Adam V.
Publicado 2020

E. coli nitroreductase NfsA is a reporter gene for non-invasive PET imaging in cancer gene therapy applications

por Mowday, Alexandra Marie, Copp, Janine Naomi, Syddall, Sophie Philippa, Dubois, Ludwig Jerome, Wang, Jingli, Lieuwes, Natasja Gabi, Biemans, Rianne, Ashoorzadeh, Amir, Abbattista, Maria Rosaria, Williams, Elsie May, Guise, Christopher Paul, Lambin, Philippe, Ackerley, David Francis, Smaill, Jeff Bruce, Theys, Jan, Patterson, Adam Vorn
Publicado 2020

Restoring Tumour Selectivity of the Bioreductive Prodrug PR-104 by Developing an Analogue Resistant to Aerobic Metabolism by Human Aldo-Keto Reductase 1C3

por Abbattista, Maria R., Ashoorzadeh, Amir, Guise, Christopher P., Mowday, Alexandra M., Mittra, Rituparna, Silva, Shevan, Hicks, Kevin O., Bull, Matthew R., Jackson-Patel, Victoria, Lin, Xiaojing, Prosser, Gareth A., Lambie, Neil K., Dachs, Gabi U., Ackerley, David F., Smaill, Jeff B., Patterson, Adam V.
Publicado 2021

Selectively Targeting Tumor Hypoxia With the Hypoxia-Activated Prodrug CP-506

por van der Wiel, Alexander M.A., Jackson-Patel, Victoria, Niemans, Raymon, Yaromina, Ala, Liu, Emily, Marcus, Damiënne, Mowday, Alexandra M., Lieuwes, Natasja G., Biemans, Rianne, Lin, Xiaojing, Fu, Zhe, Kumara, Sisira, Jochems, Arthur, Ashoorzadeh, Amir, Anderson, Robert F., Hicks, Kevin O., Bull, Matthew R., Abbattista, Maria R., Guise, Christopher P., Deschoemaeker, Sofie, Thiolloy, Sophie, Heyerick, Arne, Solivio, Morwena J., Balbo, Silvia, Smaill, Jeff B., Theys, Jan, Dubois, Ludwig J., Patterson, Adam V., Lambin, Philippe
Publicado 2021