Editorial: Characterization of biotherapeutic products

por Rathore, Anurag S., Smales, C. Mark, Guttman, Andras
Publicado 2022

The future of host cell protein (HCP) identification during process development and manufacturing linked to a risk‐based management for their control

por Bracewell, Daniel G., Francis, Richard, Smales, C. Mark
Publicado 2015

Effects of lysosomal biotherapeutic recombinant protein expression on cell stress and protease and general host cell protein release in Chinese hamster ovary cells

por Migani, Damiano, Smales, C. Mark, Bracewell, Daniel G.
Publicado 2017

Biotherapeutic protein formulation variables influence protein integrity and can promote post-translational modifications as shown using chicken egg white lysozyme as a model syste...

por Gourbatsi, Evdoxia, Povey, Jane, Uddin, Shahid, Smales, C. Mark
Publicado 2015

mTORC1 signalling and eIF4E/4E-BP1 translation initiation factor stoichiometry influence recombinant protein productivity from GS-CHOK1 cells

por Jossé, Lyne, Xie, Jianling, Proud, Christopher G., Smales, C. Mark
Publicado 2016

Expression of Trypanosoma brucei gambiense Antigens in Leishmania tarentolae. Potential for Use in Rapid Serodiagnostic Tests (RDTs)

por Rooney, Barrie, Piening, Turid, Büscher, Philippe, Rogé, Stijn, Smales, C. Mark
Publicado 2015

Modulation of Phosducin-Like Protein 3 (PhLP3) Levels Promotes Cytoskeletal Remodelling in a MAPK and RhoA-Dependent Manner

por Hayes, Nandini V. L., Jossé, Lyne, Smales, C. Mark, Carden, Martin J.
Publicado 2011

(1)H NMR Spectroscopy Profiling of Metabolic Reprogramming of Chinese Hamster Ovary Cells upon a Temperature Shift during Culture

por Wagstaff, Jane L., Masterton, Rosalyn J., Povey, Jane F., Smales, C. Mark, Howard, Mark J.
Publicado 2013

Defining lncRNAs Correlated with CHO Cell Growth and IgG Productivity by RNA-Seq

por Vito, Davide, Eriksen, Jens Christian, Skjødt, Christian, Weilguny, Dietmar, Rasmussen, Søren K., Smales, C. Mark
Publicado 2019

Manipulation of mRNA translation elongation influences the fragmentation of a biotherapeutic Fc‐fusion protein produced in CHO cells

por Knight, Tanya J., Povey, Jane F., Vito, Davide, Mohindra, Atul, Jaques, Colin M., Smales, C. Mark
Publicado 2022

Engineered transient and stable overexpression of translation factors eIF3i and eIF3c in CHOK1 and HEK293 cells gives enhanced cell growth associated with increased c-Myc expressio...

por Roobol, Anne, Roobol, Joanne, Smith, Matthew E., Carden, Martin J., Hershey, John W.B., Willis, Anne E., Smales, C. Mark
Publicado 2020

Cooling-induced SUMOylation of EXOSC10 down-regulates ribosome biogenesis

por Knight, John R.P., Bastide, Amandine, Peretti, Diego, Roobol, Anne, Roobol, Jo, Mallucci, Giovanna R., Smales, C. Mark, Willis, Anne E.
Publicado 2016

Experimental and In Silico Modelling Analyses of the Gene Expression Pathway for Recombinant Antibody and By-Product Production in NS0 Cell Lines

por Mead, Emma J., Chiverton, Lesley M., Spurgeon, Sarah K., Martin, Elaine B., Montague, Gary A., Smales, C. Mark, von der Haar, Tobias
Publicado 2012

Quantitative definition and monitoring of the host cell protein proteome using iTRAQ – a study of an industrial mAb producing CHO‐S cell line

por Chiverton, Lesley M., Evans, Caroline, Pandhal, Jagroop, Landels, Andrew R., Rees, Byron J., Levison, Peter R., Wright, Phillip C., Smales, C. Mark
Publicado 2016

Eukaryotic Elongation Factor 2 Kinase Activity Is Required for the Phenotypes of the Rpl24(Bst) Mouse

por Knight, John R.P., Proud, Christopher G., Mallucci, Giovanna, von der Haar, Tobias, Smales, C. Mark, Willis, Anne E., Sansom, Owen J.
Publicado 2022

Translation of in vitro-transcribed RNA therapeutics

por von der Haar, Tobias, Mulroney, Thomas E., Hedayioglu, Fabio, Kurusamy, Sathishkumar, Rust, Maria, Lilley, Kathryn S., Thaventhiran, James E., Willis, Anne E., Smales, C. Mark
Publicado 2023

Intact-Cell MALDI-ToF Mass Spectrometry for the Authentication of Drug-Adapted Cancer Cell Lines

por Povey, Jane F., Saintas, Emily, Aderemi, Adewale V., Rothweiler, Florian, Zehner, Richard, Dirks, Wilhelm G., Cinatl, Jindrich, Racher, Andrew J., Wass, Mark N., Smales, C. Mark, Michaelis, Martin
Publicado 2019

Engineering of Chinese hamster ovary cell lipid metabolism results in an expanded ER and enhanced recombinant biotherapeutic protein production

por Budge, James D., Knight, Tanya J., Povey, Jane, Roobol, Joanne, Brown, Ian R., Singh, Gurdeep, Dean, Andrew, Turner, Sarah, Jaques, Colin M., Young, Robert J., Racher, Andrew J., Smales, C. Mark
Publicado 2020

Data for engineering lipid metabolism of Chinese hamster ovary (CHO) cells for enhanced recombinant protein production

por Budge, James D., Knight, Tanya J., Povey, Jane, Roobol, Joanne, Brown, Ian R., Singh, Gurdeep, Dean, Andrew, Turner, Sarah, Jaques, Colin M., Young, Robert J., Racher, Andrew J., Smales, C Mark
Publicado 2020

A proline metabolism selection system and its application to the engineering of lipid biosynthesis in Chinese hamster ovary cells

por Budge, James D., Roobol, Joanne, Singh, Gurdeep, Mozzanino, Théo, Knight, Tanya J., Povey, Jane, Dean, Andrew, Turner, Sarah J., Jaques, Colin M., Young, Robert J., Racher, Andrew J., Smales, C. Mark
Publicado 2021