CCL2 is transcriptionally controlled by the lysosomal protease cathepsin S in a CD74-dependent manner

por Wilkinson, Richard D.A., Magorrian, Sinead M., Williams, Rich, Young, Andrew, Small, Donna M., Scott, Christopher J., Burden, Roberta E.
Publicado 2015

Secretory Leucoprotease Inhibitor (SLPI) Promotes Survival during Acute Pseudomonas aeruginosa Infection by Suppression of Inflammation Rather Than Microbial Killing

por Osbourn, Megan, Rodgers, Aoife M., Dubois, Alice V., Small, Donna M., Humphries, Fiachra, Delagic, Nezira, Moynagh, Paul N., Weldon, Sinéad, Taggart, Clifford C., Ingram, Rebecca J.
Publicado 2022

Therapeutic Inhibition of Cathepsin S Reduces Inflammation and Mucus Plugging in Adult βENaC-Tg Mice

por Brown, Ryan, Small, Donna M., Doherty, Declan F., Holsinger, Leslie, Booth, Robert, Williams, Richard, Ingram, Rebecca J., Elborn, J. Stuart, Mall, Marcus A., Taggart, Clifford C., Weldon, Sinéad
Publicado 2021

Activation of innate-adaptive immune machinery by poly(I:C) exposes a therapeutic vulnerability to prevent relapse in stroma-rich colon cancer

por Corry, Shania M, McCorry, Amy MB, Lannagan, Tamsin RM, Leonard, Niamh A, Fisher, Natalie C, Byrne, Ryan M, Tsantoulis, Petros, Cortes-Lavaud, Xabier, Amirkhah, Raheleh, Redmond, Keara L, McCooey, Aoife J, Malla, Sudhir B, Rogan, Emily, Sakhnevych, Svetlana, Gillespie, Michael A, White, Mark, Richman, Susan D, Jackstadt, Rene-Filip, Campbell, Andrew D, Maguire, Sarah, McDade, Simon S, Longley, Daniel B, Loughrey, Maurice B, Coleman, Helen G, Kerr, Emma M, Tejpar, Sabine, Maughan, Timothy, Leedham, Simon J, Small, Donna M, Ryan, Aideen E, Sansom, Owen J, Lawler, Mark, Dunne, Philip D
Publicado 2022