PROTAC chemical probes for histone deacetylase enzymes

por Patel, Urvashi, Smalley, Joshua P., Hodgkinson, James T.
Publicado 2023

Bifunctional HDAC Therapeutics: One Drug to Rule Them All?

por Smalley, Joshua P., Cowley, Shaun M., Hodgkinson, James T.
Publicado 2020

Comprehensive Transcriptomic Analysis of Novel Class I HDAC Proteolysis Targeting Chimeras (PROTACs)

por Baker, India M., Smalley, Joshua P., Sabat, Khadija A., Hodgkinson, James T., Cowley, Shaun M.
Publicado 2022

A ‘click’ chemistry approach to novel entinostat (MS-275) based class I histone deacetylase proteolysis targeting chimeras

por Cross, Jasmine M., Coulson, Megan E., Smalley, Joshua P., Pytel, Wiktoria A., Ismail, Ozair, Trory, Justin S., Cowley, Shaun M., Hodgkinson, James T.
Publicado 2022

Optimization of Class I Histone Deacetylase PROTACs Reveals that HDAC1/2 Degradation is Critical to Induce Apoptosis and Cell Arrest in Cancer Cells

por Smalley, Joshua P., Baker, India M., Pytel, Wiktoria A., Lin, Li-Ying, Bowman, Karen J., Schwabe, John W. R., Cowley, Shaun M., Hodgkinson, James T.
Publicado 2022