The ESC: The Dangerous By-Product of V(D)J Recombination

por Smith, Alastair L., Scott, James N. F., Boyes, Joan
Publicado 2019

Temporal analyses reveal a pivotal role for sense and antisense enhancer RNAs in coordinate immunoglobulin lambda locus activation

por Gao, Zeqian, Smith, Alastair L, Scott, James N F, Bevington, Sarah L, Boyes, Joan
Publicado 2023

Cut-and-Run: A Distinct Mechanism by which V(D)J Recombination Causes Genome Instability

por Kirkham, Christopher M., Scott, James N.F., Wang, Xiaoling, Smith, Alastair L., Kupinski, Adam P., Ford, Anthony M., Westhead, David R., Stockley, Peter G., Tuma, Roman, Boyes, Joan
Publicado 2019

Capture-C: A modular and flexible approach for high-resolution chromosome conformation capture

por Downes, Damien J., Smith, Alastair L., Karpinska, Magdalena A., Velychko, Taras, Rue-Albrecht, Kevin, Sims, David, Milne, Thomas A., Davies, James O.J., Oudelaar, A. Marieke, Hughes, Jim R.
Publicado 2022

Modelling acquired resistance to DOT1L inhibition exhibits the adaptive potential of KMT2A-rearranged acute lymphoblastic leukemia

por Schneider, Pauline, Crump, Nicholas T., Arentsen-Peters, Susan T.C.J.M., Smith, Alastair L., Hagelaar, Rico, Adriaanse, Fabienne R.S., Bos, Romy S., de Jong, Anja, Nierkens, Stefan, Koopmans, Bianca, Milne, Thomas A., Pieters, Rob, Stam, Ronald W.
Publicado 2023

DOT1L inhibition reveals a distinct subset of enhancers dependent on H3K79 methylation

por Godfrey, Laura, Crump, Nicholas T., Thorne, Ross, Lau, I-Jun, Repapi, Emmanouela, Dimou, Dimitra, Smith, Alastair L., Harman, Joe R., Telenius, Jelena M., Oudelaar, A. Marieke, Downes, Damien J., Vyas, Paresh, Hughes, Jim R., Milne, Thomas A.
Publicado 2019

MLL-AF4 cooperates with PAF1 and FACT to drive high-density enhancer interactions in leukemia

por Crump, Nicholas T., Smith, Alastair L., Godfrey, Laura, Dopico-Fernandez, Ana M., Denny, Nicholas, Harman, Joe R., Hamley, Joseph C., Jackson, Nicole E., Chahrour, Catherine, Riva, Simone, Rice, Siobhan, Kim, Jaehoon, Basrur, Venkatesha, Fermin, Damian, Elenitoba-Johnson, Kojo, Roeder, Robert G., Allis, C. David, Roberts, Irene, Roy, Anindita, Geng, Huimin, Davies, James O. J., Milne, Thomas A.
Publicado 2023