Selective inhibition of MCL1 overcomes venetoclax resistance in a murine model of myelodysplastic syndromes

por Fischer, Melissa A., Song, Yuanbin, Arrate, Maria P., Gbyli, Rana, Villaume, Matthew T., Smith, Brianna N., Childress, Merrida A., Stricker, Thomas P., Halene, Stephanie, Savona, Michael R.
Publicado 2022

Pevonedistat and azacitidine upregulate NOXA (PMAIP1) to increase sensitivity to venetoclax in preclinical models of acute myeloid leukemia

por Cojocari, Dan, Smith, Brianna N, Purkal, Julie J., Arrate, Maria P., Huska, Jason D., Xiao, Yu, Gorska, Agnieszka, Hogdal, Leah J., Ramsey, Haley E., Boghaert, Erwin R., Phillips, Darren C., Savona, Michael R.
Publicado 2021

Ribosome subunit attrition and activation of the p53–MDM4 axis dominate the response of MLL-rearranged cancer cells to WDR5 WIN site inhibition

por Howard, Gregory C., Wang, Jing, Rose, Kristie Lindsey, Patel, Purvi, Tsui, Tina, Florian, Andrea C., Lorey, Shelly L., Grieb, Brian C., Smith, Brianna N., Slota, Macey J., Reynolds, Elizabeth M., Goswami, Soumita, Savona, Michael R., Lee, Taekyu, Fesik, Stephen W., Liu, Qi, Tansey, William P.
Publicado 2023