Protein Homeostasis in Amyotrophic Lateral Sclerosis: Therapeutic Opportunities?

por Webster, Christopher P., Smith, Emma F., Shaw, Pamela J., De Vos, Kurt J.
Publicado 2017

C9orf72 plays a central role in Rab GTPase-dependent regulation of autophagy

por Webster, Christopher P., Smith, Emma F., Grierson, Andrew J., De Vos, Kurt J.
Publicado 2016

An interaction between synapsin and C9orf72 regulates excitatory synapses and is impaired in ALS/FTD

por Bauer, Claudia S., Cohen, Rebecca N., Sironi, Francesca, Livesey, Matthew R., Gillingwater, Thomas H., Highley, J. Robin, Fillingham, Daniel J., Coldicott, Ian, Smith, Emma F., Gibson, Yolanda B., Webster, Christopher P., Grierson, Andrew J., Bendotti, Caterina, De Vos, Kurt J.
Publicado 2022

The C9orf72 protein interacts with Rab1a and the ULK1 complex to regulate initiation of autophagy

por Webster, Christopher P, Smith, Emma F, Bauer, Claudia S, Moller, Annekathrin, Hautbergue, Guillaume M, Ferraiuolo, Laura, Myszczynska, Monika A, Higginbottom, Adrian, Walsh, Matthew J, Whitworth, Alexander J, Kaspar, Brian K, Meyer, Kathrin, Shaw, Pamela J, Grierson, Andrew J, De Vos, Kurt J
Publicado 2016

Loss of TMEM106B exacerbates C9ALS/FTD DPR pathology by disrupting autophagosome maturation

por Bauer, Claudia S., Webster, Christopher P., Shaw, Allan C., Kok, Jannigje R., Castelli, Lydia M., Lin, Ya-Hui, Smith, Emma F., Illanes-Álvarez, Francisco, Higginbottom, Adrian, Shaw, Pamela J., Azzouz, Mimoun, Ferraiuolo, Laura, Hautbergue, Guillaume M., Grierson, Andrew J., De Vos, Kurt J.
Publicado 2022

C9ORF72-derived poly-GA DPRs undergo endocytic uptake in iAstrocytes and spread to motor neurons

por Marchi, Paolo M, Marrone, Lara, Brasseur, Laurent, Coens, Audrey, Webster, Christopher P, Bousset, Luc, Destro, Marco, Smith, Emma F, Walther, Christa G, Alfred, Victor, Marroccella, Raffaele, Graves, Emily J, Robinson, Darren, Shaw, Allan C, Wan, Lai Mei, Grierson, Andrew J, Ebbens, Stephen J, De Vos, Kurt J, Hautbergue, Guillaume M, Ferraiuolo, Laura, Melki, Ronald, Azzouz, Mimoun
Publicado 2022

SRSF1-dependent nuclear export inhibition of C9ORF72 repeat transcripts prevents neurodegeneration and associated motor deficits

por Hautbergue, Guillaume M., Castelli, Lydia M., Ferraiuolo, Laura, Sanchez-Martinez, Alvaro, Cooper-Knock, Johnathan, Higginbottom, Adrian, Lin, Ya-Hui, Bauer, Claudia S., Dodd, Jennifer E., Myszczynska, Monika A., Alam, Sarah M., Garneret, Pierre, Chandran, Jayanth S., Karyka, Evangelia, Stopford, Matthew J., Smith, Emma F., Kirby, Janine, Meyer, Kathrin, Kaspar, Brian K., Isaacs, Adrian M., El-Khamisy, Sherif F., De Vos, Kurt J., Ning, Ke, Azzouz, Mimoun, Whitworth, Alexander J., Shaw, Pamela J.
Publicado 2017