Development of Cell Permeable NanoBRET Probes for the Measurement of PLK1 Target Engagement in Live Cells

por Yang, Xuan, Smith, Jeffery L., Beck, Michael T., Wilkinson, Jennifer M., Michaud, Ani, Vasta, James D., Robers, Matthew B., Willson, Timothy M.
Publicado 2023

Development of Cell Permeable NanoBRET Probes for the Measurement of PLK1 Target Engagement in Live Cells

por Yang, Xuan, Smith, Jeffery L., Beck, Michael T., Wilkinson, Jennifer M., Michaud, Ani, Vasta, James D., Robers, Matthew B., Willson, Timothy M.
Publicado 2023

Modulation of tau tubulin kinases (TTBK1 and TTBK2) impacts ciliogenesis

por Bashore, Frances M., Marquez, Ariana B., Chaikuad, Apirat, Howell, Stefanie, Dunn, Andrea S., Beltran, Alvaro A., Smith, Jeffery L., Drewry, David H., Beltran, Adriana S., Axtman, Alison D.
Publicado 2023

Optimization of 3-Cyano-7-cyclopropylamino-pyrazolo[1,5-a]pyrimidines Toward the Development of an In Vivo Chemical Probe for CSNK2A

por Yang, Xuan, Ong, Han Wee, Dickmander, Rebekah J., Smith, Jeffery L., Brown, Jason W., Tao, William, Chang, Edcon, Moorman, Nathaniel J., Axtman, Alison D., Willson, Timothy M.
Publicado 2023

Optimization of 3-Cyano-7-cyclopropylamino-pyrazolo[1,5-a]pyrimidines toward the Development of an In Vivo Chemical Probe for CSNK2A

por Yang, Xuan, Ong, Han Wee, Dickmander, Rebekah J., Smith, Jeffery L., Brown, Jason W., Tao, William, Chang, Edcon, Moorman, Nathaniel J., Axtman, Alison D., Willson, Timothy M.
Publicado 2023

Protein proximity networks and functional evaluation of the casein kinase 1 gamma family reveal unique roles for CK1γ3 in WNT signaling

por Agajanian, Megan J., Potjewyd, Frances M., Bowman, Brittany M., Solomon, Smaranda, LaPak, Kyle M., Bhatt, Dhaval P., Smith, Jeffery L., Goldfarb, Dennis, Axtman, Alison D., Major, Michael B.
Publicado 2022

A Hybrid III stepped wedge cluster randomized trial testing an implementation strategy to facilitate the use of an evidence-based practice in VA Homeless Primary Care Treatment Pro...

por Simmons, Molly M., Gabrielian, Sonya, Byrne, Thomas, McCullough, Megan B., Smith, Jeffery L., Taylor, Thom J., O’Toole, Tom P., Kane, Vincent, Yakovchenko, Vera, McInnes, D. Keith, Smelson, David A.
Publicado 2017

Discovery of a Potent and Selective Naphthyridine-Based Chemical Probe for Casein Kinase 2

por Davis-Gilbert, Zachary W., Krämer, Andreas, Dunford, James E., Howell, Stefanie, Senbabaoglu, Filiz, Wells, Carrow I., Bashore, Frances M., Havener, Tammy M., Smith, Jeffery L., Hossain, Mohammad A., Oppermann, Udo, Drewry, David H., Axtman, Alison D.
Publicado 2023

Identification and Utilization of a Chemical Probe to Interrogate the Roles of PIKfyve in the Lifecycle of β-Coronaviruses

por Drewry, David H., Potjewyd, Frances M., Bayati, Armin, Smith, Jeffery L., Dickmander, Rebekah J., Howell, Stefanie, Taft-Benz, Sharon, Min, Sophia M., Hossain, Mohammad Anwar, Heise, Mark, McPherson, Peter S., Moorman, Nathaniel J., Axtman, Alison D.
Publicado 2022

Discovery of a Potent and Selective CDKL5/GSK3 Chemical Probe That Is Neuroprotective

por Ong, Han Wee, Liang, Yi, Richardson, William, Lowry, Emily R., Wells, Carrow I., Chen, Xiangrong, Silvestre, Margaux, Dempster, Kelvin, Silvaroli, Josie A., Smith, Jeffery L., Wichterle, Hynek, Pabla, Navjot S., Ultanir, Sila K., Bullock, Alex N., Drewry, David H., Axtman, Alison D.
Publicado 2023

A Potent and Selective CDKL5/GSK3 Chemical Probe is Neuroprotective

por Ong, Han Wee, Liang, Yi, Richardson, William, Lowry, Emily R., Wells, Carrow I., Chen, Xiangrong, Silvestre, Margaux, Dempster, Kelvin, Silvaroli, Josie A., Smith, Jeffery L., Wichterle, Hynek, Pabla, Navjot S., Ultanir, Sila K., Bullock, Alex N., Drewry, David H., Axtman, Alison D.
Publicado 2023

Host kinase CSNK2 is a target for inhibition of pathogenic β-coronaviruses including SARS-CoV-2

por Yang, Xuan, Dickmander, Rebekah J., Bayati, Armin, Taft-Benz, Sharon A., Smith, Jeffery L., Wells, Carrow I., Madden, Emily A., Brown, Jason W., Lenarcic, Erik M., Yount, Boyd L., Chang, Edcon, Axtman, Alison D., Baric, Ralph S., Heise, Mark T., McPherson, Peter S., Moorman, Nathaniel J., Willson, Timothy M.
Publicado 2022

Host Kinase CSNK2 is a Target for Inhibition of Pathogenic SARS-like β-Coronaviruses

por Yang, Xuan, Dickmander, Rebekah J., Bayati, Armin, Taft-Benz, Sharon A., Smith, Jeffery L., Wells, Carrow I., Madden, Emily A., Brown, Jason W., Lenarcic, Erik M., Yount, Boyd L., Chang, Edcon, Axtman, Alison D., Baric, Ralph S., Heise, Mark T., McPherson, Peter S., Moorman, Nathaniel J., Willson, Timothy M.
Publicado 2022

Discovery and characterization of a specific inhibitor of serine-threonine kinase cyclin-dependent kinase-like 5 (CDKL5) demonstrates role in hippocampal CA1 physiology

por Castano, Anna, Silvestre, Margaux, Wells, Carrow I, Sanderson, Jennifer L, Ferrer, Carla A, Ong, Han Wee, Lang, Yi, Richardson, William, Silvaroli, Josie A, Bashore, Frances M, Smith, Jeffery L, Genereux, Isabelle M, Dempster, Kelvin, Drewry, David H, Pabla, Navlot S, Bullock, Alex N, Benke, Tim A, Ultanir, Sila K, Axtman, Alison D
Publicado 2023