Trisomy 21 causes changes in the circulating proteome indicative of chronic autoinflammation

por Sullivan, Kelly D., Evans, Donald, Pandey, Ahwan, Hraha, Thomas H., Smith, Keith P., Markham, Neil, Rachubinski, Angela L., Wolter-Warmerdam, Kristine, Hickey, Francis, Espinosa, Joaquin M., Blumenthal, Thomas
Publicado 2017

Trisomy 21 consistently activates the interferon response

por Sullivan, Kelly D, Lewis, Hannah C, Hill, Amanda A, Pandey, Ahwan, Jackson, Leisa P, Cabral, Joseph M, Smith, Keith P, Liggett, L Alexander, Gomez, Eliana B, Galbraith, Matthew D, DeGregori, James, Espinosa, Joaquín M
Publicado 2016

Cell differentiation modifies the p53 transcriptional program through a combination of gene silencing and constitutive transactivation

por Tatavosian, Roubina, Donovan, Micah G., Galbraith, Matthew D., Duc, Huy N., Szwarc, Maria M., Joshi, Molishree U., Frieman, Amy, Bilousova, Ganna, Cao, Yingqiong, Smith, Keith P., Song, Kunhua, Rachubinski, Angela L., Andrysik, Zdenek, Espinosa, Joaquin M.
Publicado 2023

IGF1 deficiency integrates stunted growth and neurodegeneration in Down syndrome

por Araya, Paula, Kinning, Kohl T., Coughlan, Christina, Smith, Keith P., Granrath, Ross E., Enriquez-Estrada, Belinda A., Worek, Kayleigh, Sullivan, Kelly D., Rachubinski, Angela L., Wolter-Warmerdam, Kristine, Hickey, Francis, Galbraith, Matthew D., Potter, Huntington, Espinosa, Joaquin M.
Publicado 2022

Multidimensional definition of the interferonopathy of Down syndrome and its response to JAK inhibition

por Galbraith, Matthew D., Rachubinski, Angela L., Smith, Keith P., Araya, Paula, Waugh, Katherine A., Enriquez-Estrada, Belinda, Worek, Kayleigh, Granrath, Ross E., Kinning, Kohl T., Paul Eduthan, Neetha, Ludwig, Michael P., Hsieh, Elena W. Y., Sullivan, Kelly D., Espinosa, Joaquin M.
Publicado 2023

Trisomy 21 dysregulates T cell lineages toward an autoimmunity-prone state associated with interferon hyperactivity

por Araya, Paula, Waugh, Katherine A., Sullivan, Kelly D., Núñez, Nicolás G., Roselli, Emiliano, Smith, Keith P., Granrath, Ross E., Rachubinski, Angela L., Enriquez Estrada, Belinda, Butcher, Eric T., Minter, Ross, Tuttle, Kathryn D., Bruno, Tullia C., Maccioni, Mariana, Espinosa, Joaquín M.
Publicado 2019

Seroconversion stages COVID19 into distinct pathophysiological states

por Galbraith, Matthew D., Kinning, Kohl T., Sullivan, Kelly D., Baxter, Ryan, Araya, Paula, Jordan, Kimberly R., Russell, Seth, Smith, Keith P., Granrath, Ross E., Shaw, Jessica, Dzieciatkowska, Monika, Ghosh, Tusharkanti, Monte, Andrew A., D’Alessandro, Angelo, Hansen, Kirk C., Bennett, Tellen D., Hsieh, Elena W.Y., Espinosa, Joaquin M.
Publicado 2020

Seroconversion stages COVID19 into distinct pathophysiological states

por Galbraith, Matthew D, Kinning, Kohl T, Sullivan, Kelly D, Baxter, Ryan, Araya, Paula, Jordan, Kimberly R, Russell, Seth, Smith, Keith P, Granrath, Ross E, Shaw, Jessica R, Dzieciatkowska, Monika, Ghosh, Tusharkanti, Monte, Andrew A, D'Alessandro, Angelo, Hansen, Kirk C, Benett, Tellen D, Hsieh, Elena WY, Espinosa, Joaquín M
Publicado 2021

Trisomy 21 activates the kynurenine pathway via increased dosage of interferon receptors

por Powers, Rani K., Culp-Hill, Rachel, Ludwig, Michael P., Smith, Keith P., Waugh, Katherine A., Minter, Ross, Tuttle, Kathryn D., Lewis, Hannah C., Rachubinski, Angela L., Granrath, Ross E., Carmona-Iragui, María, Wilkerson, Rebecca B., Kahn, Darcy E., Joshi, Molishree, Lleó, Alberto, Blesa, Rafael, Fortea, Juan, D’Alessandro, Angelo, Costello, James C., Sullivan, Kelly D., Espinosa, Joaquin M.
Publicado 2019

The COVIDome Explorer Researcher Portal

por Sullivan, Kelly D., Galbraith, Matthew D., Kinning, Kohl T., Bartsch, Kyle, Levinsky, Nik, Araya, Paula, Smith, Keith P., Granrath, Ross E., Shaw, Jessica R., Baxter, Ryan, Jordan, Kimberly R., Russell, Seth, Dzieciatkowska, Monika, Reisz, Julie A., Gamboni, Fabia, Cendali, Francesca, Ghosh, Tusharkanti, Monte, Andrew A., Bennett, Tellen D., Miller, Michael G., Hsieh, Elena W.Y., D’Alessandro, Angelo, Hansen, Kirk C., Espinosa, Joaquin M.
Publicado 2021

Specialized interferon action in COVID-19

por Galbraith, Matthew D., Kinning, Kohl T., Sullivan, Kelly D., Araya, Paula, Smith, Keith P., Granrath, Ross E., Shaw, Jessica R., Baxter, Ryan, Jordan, Kimberly R., Russell, Seth, Dzieciatkowska, Monika, Reisz, Julie A., Gamboni, Fabia, Cendali, Francesca, Ghosh, Tusharkanti, Guo, Kejun, Wilson, Cara C., Santiago, Mario L., Monte, Andrew A., Bennett, Tellen D., Hansen, Kirk C., Hsieh, Elena W. Y., D’Alessandro, Angelo, Espinosa, Joaquin M.
Publicado 2022

Triplication of the interferon receptor locus contributes to hallmarks of Down syndrome in a mouse model

por Waugh, Katherine A., Minter, Ross, Baxter, Jessica, Chi, Congwu, Galbraith, Matthew D., Tuttle, Kathryn D., Eduthan, Neetha P., Kinning, Kohl T., Andrysik, Zdenek, Araya, Paula, Dougherty, Hannah, Dunn, Lauren N., Ludwig, Michael, Schade, Kyndal A., Tracy, Dayna, Smith, Keith P., Granrath, Ross E., Busquet, Nicolas, Khanal, Santosh, Anderson, Ryan D., Cox, Liza L., Estrada, Belinda Enriquez, Rachubinski, Angela L., Lyford, Hannah R., Britton, Eleanor C., Fantauzzo, Katherine A., Orlicky, David J., Matsuda, Jennifer L., Song, Kunhua, Cox, Timothy C., Sullivan, Kelly D., Espinosa, Joaquin M.
Publicado 2023