Targeting MITF in the tolerance-phase

por Arozarena, Imanol, Smith, Michael P., Wellbrock, Claudia
Publicado 2016

Fibroblast Growth Factor Receptors (FGFRs) and Noncanonical Partners in Cancer Signaling

por Ferguson, Harriet R., Smith, Michael P., Francavilla, Chiara
Publicado 2021

Collagen abundance controls melanoma phenotypes through lineage-specific microenvironment sensing

por Miskolczi, Zsofia, Smith, Michael P., Rowling, Emily J., Ferguson, Jennifer, Barriuso, Jorge, Wellbrock, Claudia
Publicado 2018

Effect of SMURF2 Targeting on Susceptibility to MEK Inhibitors in Melanoma

por Smith, Michael P., Ferguson, Jennifer, Arozarena, Imanol, Hayward, Robert, Marais, Richard, Chapman, Anna, Hurlstone, Adam, Wellbrock, Claudia
Publicado 2013

A PAX3/BRN2 rheostat controls the dynamics of BRAF mediated MITF regulation in MITF(high)/AXL(low) melanoma

por Smith, Michael P., Rana, Sareena, Ferguson, Jennifer, Rowling, Emily J., Flaherty, Keith T., Wargo, Jennifer A., Marais, Richard, Wellbrock, Claudia
Publicado 2018

Osteoblasts contribute to a protective niche that supports melanoma cell proliferation and survival

por Ferguson, Jennifer, Wilcock, Daniel J., McEntegart, Sophie, Badrock, Andrew P., Levesque, Mitch, Dummer, Reinhard, Wellbrock, Claudia, Smith, Michael P.
Publicado 2019

Discovery of a Gatekeeper Residue in the C-Terminal Tail of the Extracellular Signal-Regulated Protein Kinase 5 (ERK5)

por Pearson, Adam J., Fullwood, Paul, Toro Tapia, Gabriela, Prise, Ian, Smith, Michael P., Xu, Qiuping, Jordan, Allan, Giurisato, Emanuele, Whitmarsh, Alan J., Francavilla, Chiara, Tournier, Cathy
Publicado 2020

Human Melanoma-Associated Mast Cells Display a Distinct Transcriptional Signature Characterized by an Upregulation of the Complement Component 3 That Correlates With Poor Prognosis

por Bahri, Rajia, Kiss, Orsolya, Prise, Ian, Garcia-Rodriguez, Karen M., Atmoko, Haris, Martínez-Gómez, Julia M., Levesque, Mitchell P., Dummer, Reinhard, Smith, Michael P., Wellbrock, Claudia, Bulfone-Paus, Silvia
Publicado 2022

Spatially resolved phosphoproteomics reveals fibroblast growth factor receptor recycling-driven regulation of autophagy and survival

por Watson, Joanne, Ferguson, Harriet R., Brady, Rosie M., Ferguson, Jennifer, Fullwood, Paul, Mo, Hanyi, Bexley, Katherine H., Knight, David, Howell, Gareth, Schwartz, Jean-Marc, Smith, Michael P., Francavilla, Chiara
Publicado 2022

Reciprocal priming between receptor tyrosine kinases at recycling endosomes orchestrates cellular signalling outputs

por Smith, Michael P, Ferguson, Harriet R, Ferguson, Jennifer, Zindy, Egor, Kowalczyk, Katarzyna M, Kedward, Thomas, Bates, Christian, Parsons, Joseph, Watson, Joanne, Chandler, Sarah, Fullwood, Paul, Warwood, Stacey, Knight, David, Clarke, Robert B, Francavilla, Chiara
Publicado 2021

Inhibiting Drivers of Non-mutational Drug Tolerance Is a Salvage Strategy for Targeted Melanoma Therapy

por Smith, Michael P., Brunton, Holly, Rowling, Emily J., Ferguson, Jennifer, Arozarena, Imanol, Miskolczi, Zsofia, Lee, Jessica L., Girotti, Maria R., Marais, Richard, Levesque, Mitchell P., Dummer, Reinhard, Frederick, Dennie T., Flaherty, Keith T., Cooper, Zachary A., Wargo, Jennifer A., Wellbrock, Claudia
Publicado 2016

An adaptive signaling network in melanoma inflammatory niches confers tolerance to MAPK signaling inhibition

por Young, Helen L., Rowling, Emily J., Bugatti, Mattia, Giurisato, Emanuele, Luheshi, Nadia, Arozarena, Imanol, Acosta, Juan-Carlos, Kamarashev, Jivko, Frederick, Dennie T., Cooper, Zachary A., Reuben, Alexandre, Gil, Jesus, Flaherty, Keith T., Wargo, Jennifer A., Vermi, William, Smith, Michael P., Wellbrock, Claudia, Hurlstone, Adam
Publicado 2017

Targeting endothelin receptor signalling overcomes heterogeneity driven therapy failure

por Smith, Michael P, Rowling, Emily J, Miskolczi, Zsofia, Ferguson, Jennifer, Spoerri, Loredana, Haass, Nikolas K, Sloss, Olivia, McEntegart, Sophie, Arozarena, Imanol, von Kriegsheim, Alex, Rodriguez, Javier, Brunton, Holly, Kmarashev, Jivko, Levesque, Mitchell P, Dummer, Reinhard, Frederick, Dennie T, Andrews, Miles C, Cooper, Zachary A, Flaherty, Keith T, Wargo, Jennifer A, Wellbrock, Claudia
Publicado 2017

Oxidative stress from DGAT1 oncoprotein inhibition in melanoma suppresses tumor growth when ROS defenses are also breached

por Wilcock, Daniel J., Badrock, Andrew P., Wong, Chun W., Owen, Rhys, Guerin, Melissa, Southam, Andrew D., Johnston, Hannah, Telfer, Brian A., Fullwood, Paul, Watson, Joanne, Ferguson, Harriet, Ferguson, Jennifer, Lloyd, Gavin R., Jankevics, Andris, Dunn, Warwick B., Wellbrock, Claudia, Lorigan, Paul, Ceol, Craig, Francavilla, Chiara, Smith, Michael P., Hurlstone, Adam F.L.
Publicado 2022

PARP14 inhibition restores PD-1 immune checkpoint inhibitor response following IFNγ-driven acquired resistance in preclinical cancer models

por Wong, Chun Wai, Evangelou, Christos, Sefton, Kieran N., Leshem, Rotem, Zhang, Wei, Gopalan, Vishaka, Chattrakarn, Sorayut, Fernandez Carro, Macarena Lucia, Uzuner, Erez, Mole, Holly, Wilcock, Daniel J., Smith, Michael P., Sergiou, Kleita, Telfer, Brian A., Isaac, Dervla T., Liu, Chang, Perl, Nicholas R., Marie, Kerrie, Lorigan, Paul, Williams, Kaye J., Rao, Patricia E., Nagaraju, Raghavendar T., Niepel, Mario, Hurlstone, Adam F. L.
Publicado 2023