Characterization of guinea pig T cell responses elicited after EP-assisted delivery of DNA vaccines to the skin

por Schultheis, Katherine, Schaefer, Hubert, Yung, Bryan S., Oh, Janet, Muthumani, Karuppiah, Humeau, Laurent, Broderick, Kate E., Smith, Trevor R.F.
Publicado 2016

Active Immunoprophylaxis and Vaccine Augmentations Mediated by a Novel Plasmid DNA Formulation

por Schommer, Nina N., Nguyen, Jacklyn, Yung, Bryan S., Schultheis, Katherine, Muthumani, Kar, Weiner, David B., Humeau, Laurent, Broderick, Kate E., Smith, Trevor R.F.
Publicado 2019

DNA vaccination strategy targets epidermal dendritic cells, initiating their migration and induction of a host immune response

por Smith, Trevor RF, Schultheis, Katherine, Kiosses, William B, Amante, Dinah H, Mendoza, Janess M, Stone, John C, McCoy, Jay R, Sardesai, Niranjan Y, Broderick, Kate E
Publicado 2014

Protection against Borreliella burgdorferi infection mediated by a synthetically engineered DNA vaccine

por Guibinga, Ghiabe H., Sahay, Bikash, Brown, Heather, Cooch, Neil, Chen, Jing, Yan, Jian, Reed, Charles, Mishra, Meerambika, Yung, Bryan, Pugh, Holly, Schultheis, Katherine, Esquivel, Rianne N., Weiner, David B., Humeau, Laurent H., Broderick, Kate E., Smith, Trevor R.F.
Publicado 2020

Mucosal chemokine adjuvant enhances synDNA vaccine-mediated responses to SARS-CoV-2 and provides heterologous protection in vivo

por Gary, Ebony N., Tursi, Nicholas J., Warner, Bryce, Parzych, Elizabeth M., Ali, Ali R., Frase, Drew, Moffat, Estella, Embury-Hyatt, Carissa, Smith, Trevor R.F., Broderick, Kate E., Humeau, Laurent, Kobasa, Darwyn, Patel, Ami, Kulp, Daniel W., Weiner, David B.
Publicado 2022

In Vivo Delivery of a DNA-Encoded Monoclonal Antibody Protects Non-human Primates against Zika Virus

por Esquivel, Rianne N., Patel, Ami, Kudchodkar, Sagar B., Park, Daniel H., Stettler, Karin, Beltramello, Martina, Allen, Jeffrey W., Mendoza, Janess, Ramos, Stephanie, Choi, Hyeree, Borole, Piyush, Asija, Kanika, Bah, Mamadou, Shaheen, Shareef, Chen, Jing, Yan, Jian, Durham, Amy C., Smith, Trevor R.F., Broderick, Kate, Guibinga, Ghiabe, Muthumani, Kar, Corti, Davide, Humeau, Laurent, Weiner, David B.
Publicado 2019

Prime-boost vaccination regimens with INO-4800 and INO-4802 augment and broaden immune responses against SARS-CoV-2 in nonhuman primates

por Walters, Jewell N., Schouest, Blake, Patel, Ami, Reuschel, Emma L., Schultheis, Katherine, Parzych, Elizabeth, Maricic, Igor, Gary, Ebony N., Purwar, Mansi, Andrade, Viviane M., Doan, Arthur, Elwood, Dustin, Eblimit, Zeena, Nguyen, Brian, Frase, Drew, Zaidi, Faraz I., Kulkarni, Abhijeet, Generotti, Alison, Joseph Kim, J, Humeau, Laurent M., Ramos, Stephanie J., Smith, Trevor R.F., Weiner, David B., Broderick, Kate E.
Publicado 2022

One or two dose regimen of the SARS-CoV-2 synthetic DNA vaccine INO-4800 protects against respiratory tract disease burden in nonhuman primate challenge model

por Gooch, Karen E., Smith, Trevor R.F., Salguero, Francisco J., Fotheringham, Susan A., Watson, Robert J., Dennis, Mike J., Handley, Alastair, Humphries, Holly E., Longet, Stephanie, Tipton, Tom, Sarfas, Charlotte, Sibley, Laura, Slack, Gillian S., Rayner, Emma, Ryan, Kathryn A., Schultheis, Katherine, Ramos, Stephanie J., White, Andrew, Charlton, Sue, Sharpe, Sally A., Gleeson, Fergus, Humeau, Laurent M., Hall, Yper, Broderick, Kate E., Carroll, Miles W.
Publicado 2021

In Vivo Delivery of Synthetic Human DNA-Encoded Monoclonal Antibodies Protect against Ebolavirus Infection in a Mouse Model

por Patel, Ami, Park, Daniel H., Davis, Carl W., Smith, Trevor R.F., Leung, Anders, Tierney, Kevin, Bryan, Aubrey, Davidson, Edgar, Yu, Xiaoying, Racine, Trina, Reed, Charles, Gorman, Marguerite E., Wise, Megan C., Elliott, Sarah T.C., Esquivel, Rianne, Yan, Jian, Chen, Jing, Muthumani, Kar, Doranz, Benjamin J., Saphire, Erica Ollmann, Crowe, James E., Broderick, Kate E., Kobinger, Gary P., He, Shihua, Qiu, Xiangguo, Kobasa, Darwyn, Humeau, Laurent, Sardesai, Niranjan Y., Ahmed, Rafi, Weiner, David B.
Publicado 2018

Nucleic acid delivery of immune-focused SARS-CoV-2 nanoparticles drives rapid and potent immunogenicity capable of single-dose protection

por Konrath, Kylie M., Liaw, Kevin, Wu, Yuanhan, Zhu, Xizhou, Walker, Susanne N., Xu, Ziyang, Schultheis, Katherine, Chokkalingam, Neethu, Chawla, Himanshi, Du, Jianqiu, Tursi, Nicholas J., Moore, Alan, Adolf-Bryfogle, Jared, Purwar, Mansi, Reuschel, Emma L., Frase, Drew, Sullivan, Matthew, Fry, Benjamin, Maricic, Igor, Andrade, Viviane M., Iffland, Christel, Crispin, Max, Broderick, Kate E., Humeau, Laurent M.P.F., Patel, Ami, Smith, Trevor R.F., Pallesen, Jesper, Weiner, David B., Kulp, Daniel W.
Publicado 2022

Safety and immunogenicity of INO-4800 DNA vaccine against SARS-CoV-2: A preliminary report of an open-label, Phase 1 clinical trial

por Tebas, Pablo, Yang, ShuPing, Boyer, Jean D., Reuschel, Emma L., Patel, Ami, Christensen-Quick, Aaron, Andrade, Viviane M., Morrow, Matthew P., Kraynyak, Kimberly, Agnes, Joseph, Purwar, Mansi, Sylvester, Albert, Pawlicki, Jan, Gillespie, Elisabeth, Maricic, Igor, Zaidi, Faraz I., Kim, Kevin Y., Dia, Yaya, Frase, Drew, Pezzoli, Patrick, Schultheis, Katherine, Smith, Trevor R.F., Ramos, Stephanie J., McMullan, Trevor, Buttigieg, Karen, Carroll, Miles W., Ervin, John, Diehl, Malissa C., Blackwood, Elliott, Mammen, Mammen P., Lee, Jessica, Dallas, Michael J., Brown, Ami Shah, Shea, Jacqueline E., Kim, J.Joseph, Weiner, David B., Broderick, Kate E., Humeau, Laurent M.
Publicado 2020

Intradermal-delivered DNA vaccine induces durable immunity mediating a reduction in viral load in a rhesus macaque SARS-CoV-2 challenge model

por Patel, Ami, Walters, Jewell N., Reuschel, Emma L., Schultheis, Katherine, Parzych, Elizabeth, Gary, Ebony N., Maricic, Igor, Purwar, Mansi, Eblimit, Zeena, Walker, Susanne N., Guimet, Diana, Bhojnagarwala, Pratik, Adeniji, Opeyemi S., Doan, Arthur, Xu, Ziyang, Elwood, Dustin, Reeder, Sophia M., Pessaint, Laurent, Kim, Kevin Y., Cook, Anthony, Chokkalingam, Neethu, Finneyfrock, Brad, Tello-Ruiz, Edgar, Dodson, Alan, Choi, Jihae, Generotti, Alison, Harrison, John, Tursi, Nicholas J., Andrade, Viviane M., Dia, Yaya, Zaidi, Faraz I., Andersen, Hanne, Abdel-Mohsen, Mohamed, Lewis, Mark G., Muthumani, Kar, Kim, J. Joseph, Kulp, Daniel W., Humeau, Laurent M., Ramos, Stephanie J., Smith, Trevor R.F., Weiner, David B., Broderick, Kate E.
Publicado 2021