Midbrain Organoids: A New Tool to Investigate Parkinson’s Disease

por Smits, Lisa Maria, Schwamborn, Jens Christian
Publicado 2020

Midbrain organoids mimic early embryonic neurodevelopment and recapitulate LRRK2-p.Gly2019Ser-associated gene expression

por Zagare, Alise, Barmpa, Kyriaki, Smajic, Semra, Smits, Lisa M., Grzyb, Kamil, Grünewald, Anne, Skupin, Alexander, Nickels, Sarah L., Schwamborn, Jens C.
Publicado 2022

Non-vitamin K antagonist oral anticoagulants, proton pump inhibitors and gastrointestinal bleeds

por Komen, Joris, Pottegård, Anton, Hjemdahl, Paul, Mantel-Teeuwisse, Aukje K, Wettermark, Björn, Hellfritzsch, Maja, Hallas, J, Herings, Ron, Smits, Lisa, Forslund, Thomas, Klungel, Olaf
Publicado 2022

Feasibility of Reduced Clinical Monitoring in Patients with Inflammatory Bowel Disease Treated with Thiopurine Therapy

por Jansen, Fenna M., Smits, Lisa J. T., Thomas, Pepijn W. A., de Jong, Dirk J., Kreijne, Joany E., van Dop, Willemijn A., den Broeder, Nathan, Hoentjen, Frank
Publicado 2023

Single-cell transcriptomics reveals multiple neuronal cell types in human midbrain-specific organoids

por Smits, Lisa M., Magni, Stefano, Kinugawa, Kaoru, Grzyb, Kamil, Luginbühl, Joachim, Sabate-Soler, Sonia, Bolognin, Silvia, Shin, Jay W., Mori, Eiichiro, Skupin, Alexander, Schwamborn, Jens C.
Publicado 2020

Long-Term Clinical Outcomes After Switching from Remicade(®) to Biosimilar CT-P13 in Inflammatory Bowel Disease

por Smits, Lisa J. T., Grelack, Anna, Derikx, Lauranne A. A. P., de Jong, Dirk J., van Esch, Aura A. J., Boshuizen, Ronald S., Drenth, Joost P. H., Hoentjen, Frank
Publicado 2017

De-escalation of biological therapy in inflammatory bowel disease patients following prior dose escalation

por Thomas, Pepijn W. A., Smits, Lisa J. T., Te Groen, Maarten, West, Rachel L., Russel, Maurice G. V. M., Jansen, Jeroen M., Römkens, Tessa E. H., Hoentjen, Frank
Publicado 2022

Activity of translation regulator eukaryotic elongation factor-2 kinase is increased in Parkinson disease brain and its inhibition reduces alpha synuclein toxicity

por Jan, Asad, Jansonius, Brandon, Delaidelli, Alberto, Bhanshali, Forum, An, Yi Andy, Ferreira, Nelson, Smits, Lisa M., Negri, Gian Luca, Schwamborn, Jens C., Jensen, Poul H., Mackenzie, Ian R., Taubert, Stefan, Sorensen, Poul H.
Publicado 2018

Derivation of Human Midbrain-Specific Organoids from Neuroepithelial Stem Cells

por Monzel, Anna S., Smits, Lisa M., Hemmer, Kathrin, Hachi, Siham, Moreno, Edinson Lucumi, van Wuellen, Thea, Jarazo, Javier, Walter, Jonas, Brüggemann, Inga, Boussaad, Ibrahim, Berger, Emanuel, Fleming, Ronan M.T., Bolognin, Silvia, Schwamborn, Jens C.
Publicado 2017

Modeling Parkinson’s disease in midbrain-like organoids

por Smits, Lisa M., Reinhardt, Lydia, Reinhardt, Peter, Glatza, Michael, Monzel, Anna S., Stanslowsky, Nancy, Rosato-Siri, Marcelo D., Zanon, Alessandra, Antony, Paul M., Bellmann, Jessica, Nicklas, Sarah M., Hemmer, Kathrin, Qing, Xiaobing, Berger, Emanuel, Kalmbach, Norman, Ehrlich, Marc, Bolognin, Silvia, Hicks, Andrew A., Wegner, Florian, Sterneckert, Jared L., Schwamborn, Jens C.
Publicado 2019

Parkinson's Disease Phenotypes in Patient Neuronal Cultures and Brain Organoids Improved by 2‐Hydroxypropyl‐β‐Cyclodextrin Treatment

por Jarazo, Javier, Barmpa, Kyriaki, Modamio, Jennifer, Saraiva, Cláudia, Sabaté‐Soler, Sònia, Rosety, Isabel, Griesbeck, Anne, Skwirblies, Florian, Zaffaroni, Gaia, Smits, Lisa M., Su, Jihui, Arias‐Fuenzalida, Jonathan, Walter, Jonas, Gomez‐Giro, Gemma, Monzel, Anna S., Qing, Xiaobing, Vitali, Armelle, Cruciani, Gerald, Boussaad, Ibrahim, Brunelli, Francesco, Jäger, Christian, Rakovic, Aleksandar, Li, Wen, Yuan, Lin, Berger, Emanuel, Arena, Giuseppe, Bolognin, Silvia, Schmidt, Ronny, Schröder, Christoph, Antony, Paul M.A., Klein, Christine, Krüger, Rejko, Seibler, Philip, Schwamborn, Jens C.
Publicado 2021

Cost-Effectiveness Analysis of Increased Adalimumab Dose Intervals in Crohn’s Disease Patients in Stable Remission: The Randomized Controlled LADI Trial

por Jansen, Fenna M, van Linschoten, Reinier C A, Kievit, Wietske, Smits, Lisa J T, Pauwels, Renske W M, de Jong, Dirk J, de Vries, Annemarie C, Boekema, Paul J, West, Rachel L, Bodelier, Alexander G L, Gisbertz, Ingrid A M, Wolfhagen, Frank H J, Römkens, Tessa E H, Lutgens, Maurice W M D, van Bodegraven, Adriaan A, Oldenburg, Bas, Pierik, Marieke J, Russel, Maurice G V M, de Boer, Nanne K, Mallant-Hent, Rosalie C, ter Borg, Pieter C J, van der Meulen-de Jong, Andrea E, Jansen, Jeroen M, Jansen, Sita V, Tan, Adrianus C I T L, Hoentjen, Frank, van der Woude, C Janneke
Publicado 2023