Genetic Predispositions of Glucocorticoid Resistance and Therapeutic Outcomes in Polymyalgia Rheumatica and Giant Cell Arteritis

por Smutny, Tomas, Barvik, Ivan, Veleta, Tomas, Pavek, Petr, Soukup, Tomas
Publicado 2019

Sesquiterpenes Are Agonists of the Pregnane X Receptor but Do Not Induce the Expression of Phase I Drug-Metabolizing Enzymes in the Human Liver

por Šadibolová, Michaela, Zárybnický, Tomáš, Smutný, Tomáš, Pávek, Petr, Šubrt, Zdeněk, Matoušková, Petra, Skálová, Lenka, Boušová, Iva
Publicado 2019

The 3ʹ-untranslated region contributes to the pregnane X receptor (PXR) expression down-regulation by PXR ligands and up-regulation by glucocorticoids

por Smutny, Tomas, Dusek, Jan, Hyrsova, Lucie, Nekvindova, Jana, Horvatova, Alzbeta, Micuda, Stanislav, Gerbal-Chaloin, Sabine, Pavek, Petr
Publicado 2020

Teriflunomide Is an Indirect Human Constitutive Androstane Receptor (CAR) Activator Interacting With Epidermal Growth Factor (EGF) Signaling

por Carazo, Alejandro, Dusek, Jan, Holas, Ondrej, Skoda, Josef, Hyrsova, Lucie, Smutny, Tomas, Soukup, Tomas, Dosedel, Martin, Pávek, Petr
Publicado 2018

Diazepam Promotes Translocation of Human Constitutive Androstane Receptor (CAR) via Direct Interaction with the Ligand-Binding Domain

por Skoda, Josef, Dusek, Jan, Drastik, Martin, Stefela, Alzbeta, Dohnalova, Klara, Chalupsky, Karel, Smutny, Tomas, Micuda, Stanislav, Gerbal-Chaloin, Sabine, Pavek, Petr
Publicado 2020

Discovery of Novel Human Constitutive Androstane Receptor Agonists with the Imidazo[1,2-a]pyridine Structure

por Mejdrová, Ivana, Dušek, Jan, Škach, Kryštof, Stefela, Alžbeta, Skoda, Josef, Chalupský, Karel, Dohnalová, Klára, Pavkova, Ivona, Kronenberger, Thales, Rashidian, Azam, Smutná, Lucie, Duchoslav, Vojtěch, Smutny, Tomas, Pávek, Petr, Nencka, Radim
Publicado 2023