Hypothiocyanous Acid Disrupts the Barrier Function of Brain Endothelial Cells

por van Leeuwen, Eveline, Hampton, Mark B., Smyth, Leon C. D.
Publicado 2022

Macrophage migration inhibitory factor (MIF) enhances hypochlorous acid production in phagocytic neutrophils

por Schindler, Lisa, Smyth, Leon C.D., Bernhagen, Jürgen, Hampton, Mark B., Dickerhof, Nina
Publicado 2021

Cerebrospinal fluid regulates skull bone marrow niches via direct access through dural channels

por Mazzitelli, Jose A., Smyth, Leon C.D., Cross, Kevin A., Dykstra, Taitea, Sun, Jerry, Du, Siling, Mamuladze, Tornike, Smirnov, Igor, Rustenhoven, Justin, Kipnis, Jonathan
Publicado 2022

Modelling physiological and pathological conditions to study pericyte biology in brain function and dysfunction

por Rustenhoven, Justin, Smyth, Leon C., Jansson, Deidre, Schweder, Patrick, Aalderink, Miranda, Scotter, Emma L., Mee, Edward W., Faull, Richard L. M., Park, Thomas I.-H., Dragunow, Mike
Publicado 2018

Identification of a dysfunctional microglial population in human Alzheimer’s disease cortex using novel single-cell histology image analysis

por Swanson, Molly E. V., Scotter, Emma L., Smyth, Leon C. D., Murray, Helen C., Ryan, Brigid, Turner, Clinton, Faull, Richard L. M., Dragunow, Mike, Curtis, Maurice A.
Publicado 2020

Interferon-γ blocks signalling through PDGFRβ in human brain pericytes

por Jansson, Deidre, Scotter, Emma L., Rustenhoven, Justin, Coppieters, Natacha, Smyth, Leon C. D., Oldfield, Robyn L., Bergin, Peter S., Mee, Edward W., Graham, E. Scott, Faull, Richard L. M., Dragunow, Mike
Publicado 2016

Unique and shared inflammatory profiles of human brain endothelia and pericytes

por Smyth, Leon C. D., Rustenhoven, Justin, Park, Thomas I.-H., Schweder, Patrick, Jansson, Deidre, Heppner, Peter A., O’Carroll, Simon J., Mee, Edward W., Faull, Richard L. M., Curtis, Maurice, Dragunow, Mike
Publicado 2018

Cardiac glycosides target barrier inflammation of the vasculature, meninges and choroid plexus

por Jansson, Deidre, Dieriks, Victor Birger, Rustenhoven, Justin, Smyth, Leon C. D., Scotter, Emma, Aalderink, Miranda, Feng, Sheryl, Johnson, Rebecca, Schweder, Patrick, Mee, Edward, Heppner, Peter, Turner, Clinton, Curtis, Maurice, Faull, Richard, Dragunow, Mike
Publicado 2021

Single-cell image analysis reveals a protective role for microglia in glioblastoma

por Woolf, Zoe, Swanson, Molly E V, Smyth, Leon C, Mee, Edward W, Schweder, Patrick, Heppner, Peter, Kim, Bernard J H, Turner, Clinton, Oldfield, Robyn L, Curtis, Maurice A, Faull, Richard L M, Scotter, Emma L, Park, Thomas I-H, Dragunow, Michael
Publicado 2021

Pericytes take up and degrade α-synuclein but succumb to apoptosis under cellular stress

por Stevenson, Taylor J., Johnson, Rebecca H., Savistchenko, Jimmy, Rustenhoven, Justin, Woolf, Zoe, Smyth, Leon C. D., Murray, Helen C., Faull, Richard L. M., Correia, Jason, Schweder, Patrick, Heppner, Peter, Turner, Clinton, Melki, Ronald, Dieriks, Birger V., Curtis, Maurice A., Dragunow, Michael
Publicado 2022

PU.1 regulates Alzheimer’s disease-associated genes in primary human microglia

por Rustenhoven, Justin, Smith, Amy M., Smyth, Leon C., Jansson, Deidre, Scotter, Emma L., Swanson, Molly E. V., Aalderink, Miranda, Coppieters, Natacha, Narayan, Pritika, Handley, Renee, Overall, Chris, Park, Thomas I. H., Schweder, Patrick, Heppner, Peter, Curtis, Maurice A., Faull, Richard L. M., Dragunow, Mike
Publicado 2018

Characterisation of PDGF-BB:PDGFRβ signalling pathways in human brain pericytes: evidence of disruption in Alzheimer’s disease

por Smyth, Leon C. D., Highet, Blake, Jansson, Deidre, Wu, Jane, Rustenhoven, Justin, Aalderink, Miranda, Tan, Adelie, Li, Susan, Johnson, Rebecca, Coppieters, Natacha, Handley, Renee, Narayan, Pritika, Singh-Bains, Malvindar K., Schweder, Patrick, Turner, Clinton, Mee, Edward W., Heppner, Peter, Correia, Jason, Park, Thomas I.-H., Curtis, Maurice A., Faull, Richard L. M., Dragunow, Mike
Publicado 2022

Neutrophil-vascular interactions drive myeloperoxidase accumulation in the brain in Alzheimer’s disease

por Smyth, Leon C. D., Murray, Helen C., Hill, Madison, van Leeuwen, Eve, Highet, Blake, Magon, Nicholas J., Osanlouy, Mahyar, Mathiesen, Sophie N., Mockett, Bruce, Singh-Bains, Malvindar K., Morris, Vanessa K., Clarkson, Andrew N., Curtis, Maurice A., Abraham, Wickliffe C., Hughes, Stephanie M., Faull, Richard L. M., Kettle, Anthony J., Dragunow, Mike, Hampton, Mark B.
Publicado 2022