Cell organelles are retained inside pyroptotic corpses during inflammatory cell death

por Hempel, Anne, D'Osualdo, Andrea, Snipas, Scott J., Salvesen, Guy S.
Publicado 2023

Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes

por Rut, Wioletta, Zmudzinski, Mikolaj, Snipas, Scott J., Bekes, Miklos, Huang, Tony T., Drag, Marcin
Publicado 2020

Selective chemical reagents to investigate the role of caspase 6 in apoptosis in acute leukemia T cells

por Groborz, Katarzyna M., Kalinka, Małgorzata, Grzymska, Justyna, Kołt, Sonia, Snipas, Scott J., Poręba, Marcin
Publicado 2023

Design of a Selective Substrate and Activity Based Probe for Human Neutrophil Serine Protease 4

por Kasperkiewicz, Paulina, Poreba, Marcin, Snipas, Scott J., Lin, S. Jack, Kirchhofer, Daniel, Salvesen, Guy S., Drag, Marcin
Publicado 2015

Caspase-9 inhibition confers stronger neuronal and vascular protection compared to VEGF neutralization in a mouse model of retinal vein occlusion

por Avrutsky, Maria I., Chen, Claire W., Lawson, Jacqueline M., Snipas, Scott J., Salvesen, Guy S., Troy, Carol M.
Publicado 2023

Determination of extended substrate specificity of the MALT1 as a strategy for the design of potent substrates and activity-based probes

por Kasperkiewicz, Paulina, Kołt, Sonia, Janiszewski, Tomasz, Groborz, Katarzyna, Poręba, Marcin, Snipas, Scott J., Salvesen, Guy S., Drąg, Marcin
Publicado 2018

Detection of Active Granzyme A in NK92 Cells with Fluorescent Activity-Based Probe

por Kołt, Sonia, Janiszewski, Tomasz, Kaiserman, Dion, Modrzycka, Sylwia, Snipas, Scott J., Salvesen, Guy, Dra̧g, Marcin, Bird, Phillip I., Kasperkiewicz, Paulina
Publicado 2020

Resurrection of an ancient inflammatory locus reveals switch to caspase-1 specificity on a caspase-4 scaffold

por Bibo-Verdugo, Betsaida, Joglekar, Isha, Karadi Giridhar, Mithun N., Ramirez, Monica L., Snipas, Scott J., Clark, A. Clay, Poreba, Marcin, Salvesen, Guy S.
Publicado 2022

Mechanism and specificity of the human paracaspase MALT1

por Hachmann, Janna, Snipas, Scott J., van Raam, Bram J., Cancino, Erik M., Houlihan, Emily J., Poreba, Marcin, Kasperkiewicz, Paulina, Drag, Marcin, Salvesen, Guy S.
Publicado 2012

Activity profiling and crystal structures of inhibitor-bound SARS-CoV-2 papain-like protease: A framework for anti–COVID-19 drug design

por Rut, Wioletta, Lv, Zongyang, Zmudzinski, Mikolaj, Patchett, Stephanie, Nayak, Digant, Snipas, Scott J., El Oualid, Farid, Huang, Tony T., Bekes, Miklos, Drag, Marcin, Olsen, Shaun K.
Publicado 2020

Highly sensitive and adaptable fluorescence-quenched pair discloses the substrate specificity profiles in diverse protease families

por Poreba, Marcin, Szalek, Aleksandra, Rut, Wioletta, Kasperkiewicz, Paulina, Rutkowska-Wlodarczyk, Izabela, Snipas, Scott J., Itoh, Yoshifumi, Turk, Dusan, Turk, Boris, Overall, Christopher M., Kaczmarek, Leszek, Salvesen, Guy S., Drag, Marcin
Publicado 2017

Development of a therapeutic anti-HtrA1 antibody and the identification of DKK3 as a pharmacodynamic biomarker in geographic atrophy

por Tom, Irene, Pham, Victoria C., Katschke, Kenneth J., Li, Wei, Liang, Wei-Ching, Gutierrez, Johnny, Ah Young, Andrew, Figueroa, Isabel, Eshghi, Shadi Toghi, Lee, ChingWei V., Kanodia, Jitendra, Snipas, Scott J., Salvesen, Guy S., Lai, Phillip, Honigberg, Lee, van Lookeren Campagne, Menno, Kirchhofer, Daniel, Baruch, Amos, Lill, Jennie R.
Publicado 2020