Introducing the Stem Cell ASCL2 Reporter STAR into Intestinal Organoids

por Heinz, Maria C., Oost, Koen C., Snippert, Hugo J.G.
Publicado 2020

How to create state-of-the-art genetic model systems: strategies for optimal CRISPR-mediated genome editing

por Bollen, Yannik, Post, Jasmin, Koo, Bon-Kyoung, Snippert, Hugo J G
Publicado 2018

In Vivo Imaging Reveals Existence of Crypt Fission and Fusion in Adult Mouse Intestine

por Bruens, Lotte, Ellenbroek, Saskia I.J., van Rheenen, Jacco, Snippert, Hugo J.
Publicado 2017

Biased competition between Lgr5 intestinal stem cells driven by oncogenic mutation induces clonal expansion

por Snippert, Hugo J, Schepers, Arnout G, van Es, Johan H, Simons, Benjamin D, Clevers, Hans
Publicado 2014

CRISPR-induced RASGAP deficiencies in colorectal cancer organoids reveal that only loss of NF1 promotes resistance to EGFR inhibition

por Post, Jasmin B., Hami, Nizar, Mertens, Alexander E.E., Elfrink, Suraya, Bos, Johannes L., Snippert, Hugo J.G.
Publicado 2019

Microbiota Controls the Homeostasis of Glial Cells in the Gut Lamina Propria

por Kabouridis, Panagiotis S., Lasrado, Reena, McCallum, Sarah, Chng, Song Hui, Snippert, Hugo J., Clevers, Hans, Pettersson, Sven, Pachnis, Vassilis
Publicado 2015

Intestinal crypt homeostasis revealed at single stem cell level by in vivo live-imaging

por Ritsma, Laila, Ellenbroek, Saskia I.J., Zomer, Anoek, Snippert, Hugo J., de Sauvage, Frederic J., Simons, Benjamin D., Clevers, Hans, van Rheenen, Jacco
Publicado 2014

Chromatin restriction by the nucleosome remodeler Mi-2β and functional interplay with lineage-specific transcription regulators control B-cell differentiation

por Yoshida, Toshimi, Hu, Yeguang, Zhang, Zhihong, Emmanuel, Akinola O., Galani, Kiriaki, Muhire, Brejnev, Snippert, Hugo J., Williams, Christine J., Tolstorukov, Michael Y., Gounari, Fotini, Georgopoulos, Katia
Publicado 2019

Baculoviral delivery of CRISPR/Cas9 facilitates efficient genome editing in human cells

por Hindriksen, Sanne, Bramer, Arne J., Truong, My Anh, Vromans, Martijn J. M., Post, Jasmin B., Verlaan-Klink, Ingrid, Snippert, Hugo J., Lens, Susanne M. A., Hadders, Michael A.
Publicado 2017

Multi-range ERK responses shape the proliferative trajectory of single cells following oncogene induction

por Chen, Jia-Yun, Hug, Clemens, Reyes, José, Tian, Chengzhe, Gerosa, Luca, Fröhlich, Fabian, Ponsioen, Bas, Snippert, Hugo J.G., Spencer, Sabrina L., Jambhekar, Ashwini, Sorger, Peter K., Lahav, Galit
Publicado 2023

Amplification of progenitors in the mammalian telencephalon includes a new radial glial cell type

por Pilz, Gregor-Alexander, Shitamukai, Atsunori, Reillo, Isabel, Pacary, Emilie, Schwausch, Julia, Stahl, Ronny, Ninkovic, Jovica, Snippert, Hugo J., Clevers, Hans, Godinho, Leanne, Guillemot, Francois, Borrell, Victor, Matsuzaki, Fumio, Götz, Magdalena
Publicado 2013

Integrative multi‐omics analysis of intestinal organoid differentiation

por Lindeboom, Rik GH, van Voorthuijsen, Lisa, Oost, Koen C, Rodríguez‐Colman, Maria J, Luna‐Velez, Maria V, Furlan, Cristina, Baraille, Floriane, Jansen, Pascal WTC, Ribeiro, Agnès, Burgering, Boudewijn MT, Snippert, Hugo J, Vermeulen, Michiel
Publicado 2018

Targeting mutant RAS in patient-derived colorectal cancer organoids by combinatorial drug screening

por Verissimo, Carla S, Overmeer, René M, Ponsioen, Bas, Drost, Jarno, Mertens, Sander, Verlaan-Klink, Ingrid, van Gerwen, Bastiaan, van der Ven, Marieke, van de Wetering, Marc, Egan, David A, Bernards, René, Clevers, Hans, Bos, Johannes L, Snippert, Hugo J
Publicado 2016

Efficient and error-free fluorescent gene tagging in human organoids without double-strand DNA cleavage

por Bollen, Yannik, Hageman, Joris H., van Leenen, Petra, Derks, Lucca L. M., Ponsioen, Bas, Buissant des Amorie, Julian R., Verlaan-Klink, Ingrid, van den Bos, Myrna, Terstappen, Leon W. M. M., van Boxtel, Ruben, Snippert, Hugo J. G.
Publicado 2022

Specific Labeling of Stem Cell Activity in Human Colorectal Organoids Using an ASCL2-Responsive Minigene

por Oost, Koen C., van Voorthuijsen, Lisa, Fumagalli, Arianna, Lindeboom, Rik G.H., Sprangers, Joep, Omerzu, Manja, Rodriguez-Colman, Maria J., Heinz, Maria C., Verlaan-Klink, Ingrid, Maurice, Madelon M., Burgering, Boudewijn M.T., van Rheenen, Jacco, Vermeulen, Michiel, Snippert, Hugo J.G.
Publicado 2018

Liver Colonization by Colorectal Cancer Metastases Requires YAP-Controlled Plasticity at the Micrometastatic Stage

por Heinz, Maria C., Peters, Niek A., Oost, Koen C., Lindeboom, Rik G.H., van Voorthuijsen, Lisa, Fumagalli, Arianna, van der Net, Mirjam C., de Medeiros, Gustavo, Hageman, Joris H., Verlaan-Klink, Ingrid, Borel Rinkes, Inne H.M., Liberali, Prisca, Gloerich, Martijn, van Rheenen, Jacco, Vermeulen, Michiel, Kranenburg, Onno, Snippert, Hugo J.G.
Publicado 2022

Quantifying single-cell ERK dynamics in colorectal cancer organoids reveals EGFR as an amplifier of oncogenic MAPK pathway signaling

por Ponsioen, Bas, Post, Jasmin B., des Amorie, Julian R. Buissant, Laskaris, Dimitrios, van Ineveld, Ravian L., Kersten, Simone, Bertotti, Andrea, Sassi, Francesco, Sipieter, François, Cappe, Benjamin, Mertens, Sander, Verlaan-Klink, Ingrid, Boj, Sylvia F., Vries, Rob G.J., Rehmann, Holger, Vandenabeele, Peter, Riquet, Franck B., Trusolino, Livio, Bos, Johannes L., Snippert, Hugo J.G.
Publicado 2021

Chromosomal copy number heterogeneity predicts survival rates across cancers

por van Dijk, Erik, van den Bosch, Tom, Lenos, Kristiaan J., El Makrini, Khalid, Nijman, Lisanne E., van Essen, Hendrik F. B., Lansu, Nico, Boekhout, Michiel, Hageman, Joris H., Fitzgerald, Rebecca C., Punt, Cornelis J. A., Tuynman, Jurriaan B., Snippert, Hugo J. G., Kops, Geert J. P. L., Medema, Jan Paul, Ylstra, Bauke, Vermeulen, Louis, Miedema, Daniël M.
Publicado 2021

Plasticity of Lgr5-Negative Cancer Cells Drives Metastasis in Colorectal Cancer

por Fumagalli, Arianna, Oost, Koen C., Kester, Lennart, Morgner, Jessica, Bornes, Laura, Bruens, Lotte, Spaargaren, Lisa, Azkanaz, Maria, Schelfhorst, Tim, Beerling, Evelyne, Heinz, Maria C., Postrach, Daniel, Seinstra, Danielle, Sieuwerts, Anieta M., Martens, John W.M., van der Elst, Stefan, van Baalen, Martijn, Bhowmick, Debajit, Vrisekoop, Nienke, Ellenbroek, Saskia I.J., Suijkerbuijk, Saskia J.E., Snippert, Hugo J., van Rheenen, Jacco
Publicado 2020

Retrograde movements determine effective stem cell numbers in the intestine

por Azkanaz, Maria, Corominas-Murtra, Bernat, Ellenbroek, Saskia I.J., Bruens, Lotte, Webb, Anna T., Laskaris, Dimitrios, Oost, Koen C., Lafirenze, Simona J.A., Annusver, Karl, Messal, Hendrik A., Iqbal, Sharif, Flanagan, Dustin J., Huels, David J., Rojas-Rodríguez, Felipe, Vizoso, Miguel, Kasper, Maria, Sansom, Owen J., Snippert, Hugo J., Liberali, Prisca, Simons, Benjamin D., Katajisto, Pekka, Hannezo, Edouard, van Rheenen, Jacco
Publicado 2022