Physiologically‐based pharmacokinetic modeling for investigating the effect of simeprevir on concomitant drugs and an endogenous biomarker of OATP1B

por Nakayama, Shinji, Toshimoto, Kota, Yamazaki, Shinji, Snoeys, Jan, Sugiyama, Yuichi
Publicado 2023

Drug–Drug Interactions with the NS3/4A Protease Inhibitor Simeprevir

por Ouwerkerk-Mahadevan, Sivi, Snoeys, Jan, Peeters, Monika, Beumont-Mauviel, Maria, Simion, Alexandru
Publicado 2015

Genome-wide association study of abnormal elevation of ALT in patients exposed to atabecestat

por Li, Qingqin S., Francke, Stephan, Snoeys, Jan, Thipphawong, John, Romano, Gary, Novak, Gerald P.
Publicado 2023

Population pharmacokinetic modeling and simulation to support qualification of pyridoxic acid as endogenous biomarker of OAT1/3 renal transporters

por Ahmad, Amais, Ogungbenro, Kayode, Kunze, Annett, Jacobs, Frank, Snoeys, Jan, Rostami‐Hodjegan, Amin, Galetin, Aleksandra
Publicado 2021

Oral etoposide and zosuquidar bioavailability in rats: Effect of co-administration and in vitro-in vivo correlation of P-glycoprotein inhibition

por Nielsen, Rasmus Blaaholm, Holm, René, Pijpers, Ils, Snoeys, Jan, Nielsen, Ulla Gro, Nielsen, Carsten Uhd
Publicado 2021

Combinational Inhibition of P-Glycoprotein-Mediated Etoposide Transport by Zosuquidar and Polysorbate 20

por Nielsen, Rasmus Blaaholm, Holm, René, Pijpers, Ils, Snoeys, Jan, Nielsen, Ulla Gro, Nielsen, Carsten Uhd
Publicado 2023

Short-term supplementation of celecoxib-shifted butyrate production on a simulated model of the gut microbial ecosystem and ameliorated in vitro inflammation

por Hernandez-Sanabria, Emma, Heiremans, Evelien, Calatayud Arroyo, Marta, Props, Ruben, Leclercq, Laurent, Snoeys, Jan, Van de Wiele, Tom
Publicado 2020

Drug‐Drug Interactions With the Hepatitis B Virus Capsid Assembly Modulator JNJ‐56136379 (Bersacapavir)

por Vandenbossche, Joris, Yogaratnam, Jeysen, Hillewaert, Vera, Rasschaert, Freya, Talloen, Willem, Biewenga, Jeike, Snoeys, Jan, Kakuda, Thomas N., Palmer, Martyn, Nangosyah, Julius, Biermer, Michael
Publicado 2022

Effect of CYP3A perpetrators on ibrutinib exposure in healthy participants

por de Jong, Jan, Skee, Donna, Murphy, Joe, Sukbuntherng, Juthamas, Hellemans, Peter, Smit, Johan, de Vries, Ronald, Jiao, Juhui James, Snoeys, Jan, Mannaert, Erik
Publicado 2015

Evidence-based selection of training compounds for use in the mechanism-based integrated prediction of drug-induced liver injury in man

por Dragovic, Sanja, Vermeulen, Nico P. E., Gerets, Helga H., Hewitt, Philip G., Ingelman‐Sundberg, Magnus, Park, B. Kevin, Juhila, Satu, Snoeys, Jan, Weaver, Richard J.
Publicado 2016

In Vitro Model for Hepatotoxicity Studies Based on Primary Human Hepatocyte Cultivation in a Perfused 3D Bioreactor System

por Knöspel, Fanny, Jacobs, Frank, Freyer, Nora, Damm, Georg, De Bondt, An, van den Wyngaert, Ilse, Snoeys, Jan, Monshouwer, Mario, Richter, Marco, Strahl, Nadja, Seehofer, Daniel, Zeilinger, Katrin
Publicado 2016

Prediction of the drug–drug interaction potential of the α1‐acid glycoprotein bound, CYP3A4/CYP2C9 metabolized oncology drug, erdafitinib

por De Zwart, Loeckie, Snoeys, Jan, Jacobs, Frank, Li, Lilian Y., Poggesi, Italo, Verboven, Peter, Goris, Ivo, Scheers, Ellen, Wynant, Inneke, Monshouwer, Mario, Mamidi, Rao N. V. S.
Publicado 2021

Considerations and recommendations for assessment of plasma protein binding and drug–drug interactions for siRNA therapeutics

por Humphreys, Sara C, Davis, John A, Iqbal, Sajida, Kamel, Amin, Kulmatycki, Kenneth, Lao, Yanbin, Liu, Xiumin, Rodgers, John, Snoeys, Jan, Vigil, Adam, Weng, Yan, Wiethoff, Christopher M, Wittwer, Matthias B
Publicado 2022

The utility of a differentiated preclinical liver model, HepaRG cells, in investigating delayed toxicity via inhibition of mitochondrial-replication induced by fialuridine

por Jolly, Carol E., Douglas, Oisin, Kamalian, Laleh, Jenkins, Rosalind E., Beckett, Alison J., Penman, Sophie L., Williams, Dominic P., Monshouwer, Mario, Simic, Damir, Snoeys, Jan, Park, B. Kevin, Chadwick, Amy E.
Publicado 2020

Physiologically‐Based Pharmacokinetic Modeling in Renal and Hepatic Impairment Populations: A Pharmaceutical Industry Perspective

por Heimbach, Tycho, Chen, Yuan, Chen, Jun, Dixit, Vaishali, Parrott, Neil, Peters, Sheila Annie, Poggesi, Italo, Sharma, Pradeep, Snoeys, Jan, Shebley, Mohamad, Tai, Guoying, Tse, Susanna, Upreti, Vijay V., Wang, Ying‐Hong, Tsai, Alice, Xia, Binfeng, Zheng, Ming, Zhu, Andy Z.X., Hall, Stephen
Publicado 2020

Physiologically‐Based Pharmacokinetic Models for Evaluating Membrane Transporter Mediated Drug–Drug Interactions: Current Capabilities, Case Studies, Future Opportunities, and Reco...

por Taskar, Kunal S., Pilla Reddy, Venkatesh, Burt, Howard, Posada, Maria M., Varma, Manthena, Zheng, Ming, Ullah, Mohammed, Emami Riedmaier, Arian, Umehara, Ken‐ichi, Snoeys, Jan, Nakakariya, Masanori, Chu, Xiaoyan, Beneton, Maud, Chen, Yuan, Huth, Felix, Narayanan, Rangaraj, Mukherjee, Dwaipayan, Dixit, Vaishali, Sugiyama, Yuichi, Neuhoff, Sibylle
Publicado 2019

Characterization of primary human hepatocyte spheroids as a model system for drug-induced liver injury, liver function and disease

por Bell, Catherine C., Hendriks, Delilah F. G., Moro, Sabrina M. L., Ellis, Ewa, Walsh, Joanne, Renblom, Anna, Fredriksson Puigvert, Lisa, Dankers, Anita C. A., Jacobs, Frank, Snoeys, Jan, Sison-Young, Rowena L., Jenkins, Rosalind E., Nordling, Åsa, Mkrtchian, Souren, Park, B. Kevin, Kitteringham, Neil R., Goldring, Christopher E. P., Lauschke, Volker M., Ingelman-Sundberg, Magnus
Publicado 2016

Comparison of Hepatic 2D Sandwich Cultures and 3D Spheroids for Long-term Toxicity Applications: A Multicenter Study

por Bell, Catherine C, Dankers, Anita C A, Lauschke, Volker M, Sison-Young, Rowena, Jenkins, Roz, Rowe, Cliff, Goldring, Chris E, Park, Kevin, Regan, Sophie L, Walker, Tracy, Schofield, Chris, Baze, Audrey, Foster, Alison J, Williams, Dominic P, van de Ven, Amy W M, Jacobs, Frank, van Houdt, Jos, Lähteenmäki, Tuula, Snoeys, Jan, Juhila, Satu, Richert, Lysiane, Ingelman-Sundberg, Magnus
Publicado 2018

Amino acid levels determine metabolism and CYP450 function of hepatocytes and hepatoma cell lines

por Boon, Ruben, Kumar, Manoj, Tricot, Tine, Elia, Ilaria, Ordovas, Laura, Jacobs, Frank, One, Jennifer, De Smedt, Jonathan, Eelen, Guy, Bird, Matthew, Roelandt, Philip, Doglioni, Ginevra, Vriens, Kim, Rossi, Matteo, Vazquez, Marta Aguirre, Vanwelden, Thomas, Chesnais, François, El Taghdouini, Adil, Najimi, Mustapha, Sokal, Etienne, Cassiman, David, Snoeys, Jan, Monshouwer, Mario, Hu, Wei-Shou, Lange, Christian, Carmeliet, Peter, Fendt, Sarah-Maria, Verfaillie, Catherine M.
Publicado 2020