Quantitative approaches to drug safety: The 2022 PSP special issue

por Sobie, Eric A.
Publicado 2022

Regression Analysis for Constraining Free Parameters in Electrophysiological Models of Cardiac Cells

por Sarkar, Amrita X., Sobie, Eric A.
Publicado 2010

Population-based mechanistic modeling allows for quantitative predictions of drug responses across cell types

por Gong, Jingqi Q. X., Sobie, Eric A.
Publicado 2018

In vitro and In silico Models to Study SARS-CoV-2 Infection: Integrating Experimental and Computational Tools to Mimic “COVID-19 Cardiomyocyte”

por Dariolli, Rafael, Campana, Chiara, Gutierrez, Amy, Sobie, Eric A.
Publicado 2021

Inflammation as a Risk Factor in Cardiotoxicity: An Important Consideration for Screening During Drug Development

por Campana, Chiara, Dariolli, Rafael, Boutjdir, Mohamed, Sobie, Eric A.
Publicado 2021

Ambiguous interactions between diastolic and SR Ca(2+) in the regulation of cardiac Ca(2+) release

por Sobie, Eric A., Williams, George S.B., Lederer, W.J.
Publicado 2017

Modeling Electrophysiological Coupling and Fusion between Human Mesenchymal Stem Cells and Cardiomyocytes

por Mayourian, Joshua, Savizky, Ruben M., Sobie, Eric A., Costa, Kevin D.
Publicado 2016

A privileged role for neuronal Na(+) channels in regulating ventricular [Ca(2+)] and arrhythmias

por Jones, DeAnalisa C., Gong, Jingqi Q.X., Sobie, Eric A.
Publicado 2018

Coupling and heterogeneity modulate pacemaking capability in healthy and diseased two-dimensional sinoatrial node tissue models

por Campana, Chiara, Ricci, Eugenio, Bartolucci, Chiara, Severi, Stefano, Sobie, Eric A.
Publicado 2022

Comprehensive Analyses of Ventricular Myocyte Models Identify Targets Exhibiting Favorable Rate Dependence

por Cummins, Megan A., Dalal, Pavan J., Bugana, Marco, Severi, Stefano, Sobie, Eric A.
Publicado 2014

Ca(2+) Cycling Impairment in Heart Failure Is Exacerbated by Fibrosis: Insights Gained From Mechanistic Simulations

por Mora, Maria T., Ferrero, Jose M., Gomez, Juan F., Sobie, Eric A., Trenor, Beatriz
Publicado 2018

Investigational treatments for COVID-19 may increase ventricular arrhythmia risk through drug interactions

por Varshneya, Meera, Irurzun-Arana, Itziar, Campana, Chiara, Dariolli, Rafael, Gutierrez, Amy, Pullinger, Taylor K., Sobie, Eric A.
Publicado 2020

Investigational Treatments for COVID‐19 may Increase Ventricular Arrhythmia Risk Through Drug Interactions

por Varshneya, Meera, Irurzun-Arana, Itziar, Campana, Chiara, Dariolli, Rafael, Gutierrez, Amy, Pullinger, Taylor K., Sobie, Eric A.
Publicado 2021

Investigational Treatments for COVID-19 May Increase Ventricular Arrhythmia Risk through Drug Interactions

por Varshneya, Meera, Irurzun-Arana, Itziar, Campana, Chiara, Dariolli, Rafael, Gutierrez, Amy, Pullinger, Taylor K., Sobie, Eric A.
Publicado 2021

The Contribution of Ionic Currents to Rate-Dependent Action Potential Duration and Pattern of Reentry in a Mathematical Model of Human Atrial Fibrillation

por Lee, Young-Seon, Hwang, Minki, Song, Jun-Seop, Li, Changyong, Joung, Boyoung, Sobie, Eric A., Pak, Hui-Nam
Publicado 2016

Mechanistic Systems Modeling to Improve Understanding and Prediction of Cardiotoxicity Caused by Targeted Cancer Therapeutics

por Shim, Jaehee V., Chun, Bryan, van Hasselt, Johan G. C., Birtwistle, Marc R., Saucerman, Jeffrey J., Sobie, Eric A.
Publicado 2017

Identification of novel prognostic indicators for triple-negative breast cancer patients through integrative analysis of cancer genomics data and protein interactome data

por Zhang, Fan, Ren, Chunyan, Zhao, Hengqiang, Yang, Lei, Su, Fei, Zhou, Ming-Ming, Han, Junwei, Sobie, Eric A., Walsh, Martin J.
Publicado 2016

CPT: Pharmacometrics & Systems Pharmacology – Inception, Maturation, and Future Vision

por Rowland Yeo, Karen, Hennig, Stefanie, Krishnaswami, Sriram, Strydom, Natasha, Ayyar, Vivaswath S., French, Jonathan, Sinha, Vikram, Sobie, Eric, Zhao, Ping, Friberg, Lena E., Mentré, France
Publicado 2021

Autonomous and Non-autonomous Defects Underlie Hypertrophic Cardiomyopathy in BRAF-Mutant hiPSC-Derived Cardiomyocytes

por Josowitz, Rebecca, Mulero-Navarro, Sonia, Rodriguez, Nelson A., Falce, Christine, Cohen, Ninette, Ullian, Erik M., Weiss, Lauren A., Rauen, Katherine A., Sobie, Eric A., Gelb, Bruce D.
Publicado 2016

Identification and Purification of Human Induced Pluripotent Stem Cell-Derived Atrial-Like Cardiomyocytes Based on Sarcolipin Expression

por Josowitz, Rebecca, Lu, Jia, Falce, Christine, D’Souza, Sunita L., Wu, Meng, Cohen, Ninette, Dubois, Nicole C., Zhao, Yong, Sobie, Eric A., Fishman, Glenn I., Gelb, Bruce D.
Publicado 2014