Emerging Epigenetic Therapeutic Targets in Acute Myeloid Leukemia

por Wingelhofer, Bettina, Somervaille, Tim C. P.
Publicado 2019

Dynamic induction of drug resistance through a stress-responsive enhancer in acute myeloid leukemia

por Williams, Mark S., Somervaille, Tim C. P.
Publicado 2020

The Diverse Consequences of FOXC1 Deregulation in Cancer

por Gilding, L. Niall, Somervaille, Tim C. P.
Publicado 2019

LSD1 inhibitors disrupt the GFI1 transcription repressor complex

por Maiques-Diaz, Alba, Lynch, James T., Spencer, Gary J., Somervaille, Tim C.P.
Publicado 2018

A stress-responsive enhancer induces dynamic drug resistance in acute myeloid leukemia

por Williams, Mark S., Amaral, Fabio M.R., Simeoni, Fabrizio, Somervaille, Tim C.P.
Publicado 2020

TTC5 is required to prevent apoptosis of acute myeloid leukemia stem cells

por Lynch, J T, Somerville, T D D, Spencer, G J, Huang, X, Somervaille, T C P
Publicado 2013

A personalised medicine approach for ponatinib-resistant chronic myeloid leukaemia

por Korfi, K., Mandal, A., Furney, S. J., Wiseman, D., Somervaille, T. C. P., Marais, R.
Publicado 2015

BIM mediates synergistic killing of B-cell acute lymphoblastic leukemia cells by BCL-2 and MEK inhibitors

por Korfi, K, Smith, M, Swan, J, Somervaille, T C P, Dhomen, N, Marais, R
Publicado 2016

AXL Inhibition Extinguishes Primitive JAK2 Mutated Myeloproliferative Neoplasm Progenitor Cells

por Pearson, Stella, Blance, Rognvald, Somervaille, Tim C.P., Whetton, Anthony D., Pierce, Andrew
Publicado 2019

Blast cells surviving acute myeloid leukemia induction therapy are in cycle with a signature of FOXM1 activity

por Williams, Mark S., Basma, Naseer J., Amaral, Fabio M. R., Wiseman, Daniel H., Somervaille, Tim C. P.
Publicado 2021

Enhancers of Polycomb EPC1 and EPC2 sustain the oncogenic potential of MLL leukemia stem cells

por Huang, Xu, Spencer, Gary J, Lynch, James T, Ciceri, Filippo, Somerville, Tim D D, Somervaille, Tim C P
Publicado 2013

Proteomic analysis of JAK2V617F-induced changes identifies potential new combinatorial therapeutic approaches

por Pearson, S, Williamson, A J K, Blance, R, Somervaille, T C P, Taylor, S, Azadbakht, N, Whetton, A D, Pierce, A
Publicado 2017

Erratum: Proteomic analysis of JAK2V617F-induced changes identifies potential new combinatorial therapeutic approaches

por Pearson, S, Williamson, A J K, Blance, R, Somervaille, T C P, Taylor, S, Azadbakht, N, Whetton, A D, Pierce, A
Publicado 2017

A targeted knockdown screen of genes coding for phosphoinositide modulators identifies PIP4K2A as required for acute myeloid leukemia cell proliferation and survival

por Jude, Julian G, Spencer, Gary J, Huang, Xu, Somerville, Tim D D, Jones, David R, Divecha, Nullin, Somervaille, Tim C P
Publicado 2014

EVI1 oncoprotein expression and CtBP1-association oscillate through the cell cycle

por Paredes, Roberto, Schneider, Marion, Pearson, Stella, Teng, Hsiang Yin, Kelly, James R., Pierce, Andrew, Somervaille, Tim C. P., Whetton, Anthony D., Meyer, Stefan
Publicado 2020

Pharmacological inhibition of LSD1 triggers myeloid differentiation by targeting GSE1 oncogenic functions in AML

por Nicosia, Luciano, Boffo, Francesca Ludovica, Ceccacci, Elena, Conforti, Fabio, Pallavicini, Isabella, Bedin, Fabio, Ravasio, Roberto, Massignani, Enrico, Somervaille, Tim C. P., Minucci, Saverio, Bonaldi, Tiziana
Publicado 2021

Identification of curaxin as a potential new therapeutic for JAK2 V617F mutant patients

por Pearson, Stella, Blance, Rognvald, Yan, Fei, Hsieh, Ya-Ching, Geary, Bethany, Amaral, Fabio M. R., Somervaille, Tim C. P., Kirschner, Kristina, Whetton, Anthony D., Pierce, Andrew
Publicado 2023

Differentiation block in acute myeloid leukemia regulated by intronic sequences of FTO

por Camera, Francesco, Romero-Camarero, Isabel, Revell, Bradley H., Amaral, Fabio M.R., Sinclair, Oliver J., Simeoni, Fabrizio, Wiseman, Daniel H., Stojic, Lovorka, Somervaille, Tim C.P.
Publicado 2023

Oligomeric self-association contributes to E2A-PBX1-mediated oncogenesis

por Lin, Chiou-Hong, Wang, Zhong, Duque-Afonso, Jesús, Wong, Stephen Hon-Kit, Demeter, Janos, Loktev, Alexander V., Somervaille, Tim C. P., Jackson, Peter K., Cleary, Michael L.
Publicado 2019

Targeted nanopore sequencing for the identification of ABCB1 promoter translocations in cancer

por Williams, Mark S., Basma, Naseer J., Amaral, Fabio M. R., Williams, Gillian, Weightman, John P., Breitwieser, Wolfgang, Nelson, Louisa, Taylor, Stephen S., Wiseman, Daniel H., Somervaille, Tim C. P.
Publicado 2020