Emerging Epigenetic Therapeutic Targets in Acute Myeloid Leukemia

por Wingelhofer, Bettina, Somervaille, Tim C. P.
Publicado 2019

Dynamic induction of drug resistance through a stress-responsive enhancer in acute myeloid leukemia

por Williams, Mark S., Somervaille, Tim C. P.
Publicado 2020

The Diverse Consequences of FOXC1 Deregulation in Cancer

por Gilding, L. Niall, Somervaille, Tim C. P.
Publicado 2019

LSD1 inhibitors disrupt the GFI1 transcription repressor complex

por Maiques-Diaz, Alba, Lynch, James T., Spencer, Gary J., Somervaille, Tim C.P.
Publicado 2018

A stress-responsive enhancer induces dynamic drug resistance in acute myeloid leukemia

por Williams, Mark S., Amaral, Fabio M.R., Simeoni, Fabrizio, Somervaille, Tim C.P.
Publicado 2020

AXL Inhibition Extinguishes Primitive JAK2 Mutated Myeloproliferative Neoplasm Progenitor Cells

por Pearson, Stella, Blance, Rognvald, Somervaille, Tim C.P., Whetton, Anthony D., Pierce, Andrew
Publicado 2019

Blast cells surviving acute myeloid leukemia induction therapy are in cycle with a signature of FOXM1 activity

por Williams, Mark S., Basma, Naseer J., Amaral, Fabio M. R., Wiseman, Daniel H., Somervaille, Tim C. P.
Publicado 2021

Enhancers of Polycomb EPC1 and EPC2 sustain the oncogenic potential of MLL leukemia stem cells

por Huang, Xu, Spencer, Gary J, Lynch, James T, Ciceri, Filippo, Somerville, Tim D D, Somervaille, Tim C P
Publicado 2013

A targeted knockdown screen of genes coding for phosphoinositide modulators identifies PIP4K2A as required for acute myeloid leukemia cell proliferation and survival

por Jude, Julian G, Spencer, Gary J, Huang, Xu, Somerville, Tim D D, Jones, David R, Divecha, Nullin, Somervaille, Tim C P
Publicado 2014

EVI1 oncoprotein expression and CtBP1-association oscillate through the cell cycle

por Paredes, Roberto, Schneider, Marion, Pearson, Stella, Teng, Hsiang Yin, Kelly, James R., Pierce, Andrew, Somervaille, Tim C. P., Whetton, Anthony D., Meyer, Stefan
Publicado 2020

Pharmacological inhibition of LSD1 triggers myeloid differentiation by targeting GSE1 oncogenic functions in AML

por Nicosia, Luciano, Boffo, Francesca Ludovica, Ceccacci, Elena, Conforti, Fabio, Pallavicini, Isabella, Bedin, Fabio, Ravasio, Roberto, Massignani, Enrico, Somervaille, Tim C. P., Minucci, Saverio, Bonaldi, Tiziana
Publicado 2021

Identification of curaxin as a potential new therapeutic for JAK2 V617F mutant patients

por Pearson, Stella, Blance, Rognvald, Yan, Fei, Hsieh, Ya-Ching, Geary, Bethany, Amaral, Fabio M. R., Somervaille, Tim C. P., Kirschner, Kristina, Whetton, Anthony D., Pierce, Andrew
Publicado 2023

Differentiation block in acute myeloid leukemia regulated by intronic sequences of FTO

por Camera, Francesco, Romero-Camarero, Isabel, Revell, Bradley H., Amaral, Fabio M.R., Sinclair, Oliver J., Simeoni, Fabrizio, Wiseman, Daniel H., Stojic, Lovorka, Somervaille, Tim C.P.
Publicado 2023

Oligomeric self-association contributes to E2A-PBX1-mediated oncogenesis

por Lin, Chiou-Hong, Wang, Zhong, Duque-Afonso, Jesús, Wong, Stephen Hon-Kit, Demeter, Janos, Loktev, Alexander V., Somervaille, Tim C. P., Jackson, Peter K., Cleary, Michael L.
Publicado 2019

Targeted nanopore sequencing for the identification of ABCB1 promoter translocations in cancer

por Williams, Mark S., Basma, Naseer J., Amaral, Fabio M. R., Williams, Gillian, Weightman, John P., Breitwieser, Wolfgang, Nelson, Louisa, Taylor, Stephen S., Wiseman, Daniel H., Somervaille, Tim C. P.
Publicado 2020

Derepression of the Iroquois Homeodomain Transcription Factor Gene IRX3 Confers Differentiation Block in Acute Leukemia

por Somerville, Tim D.D., Simeoni, Fabrizio, Chadwick, John A., Williams, Emma L., Spencer, Gary J., Boros, Katalin, Wirth, Christopher, Tholouli, Eleni, Byers, Richard J., Somervaille, Tim C.P.
Publicado 2018

Pre-clinical activity of combined LSD1 and mTORC1 inhibition in MLL-translocated acute myeloid leukaemia

por Deb, Gauri, Wingelhofer, Bettina, Amaral, Fabio M. R., Maiques-Diaz, Alba, Chadwick, John A., Spencer, Gary J., Williams, Emma L., Leong, Hui-Sun, Maes, Tamara, Somervaille, Tim C. P.
Publicado 2019

Frequent reconstitution of IDH2(R140Q) mutant clonal multilineage hematopoiesis following chemotherapy for acute myeloid leukemia

por Wiseman, Daniel H., Williams, Emma L., Wilks, Deepti P., Sun Leong, Hui, Somerville, Tim D. D., Dennis, Michael W., Struys, Eduard A., Bakkali, Abdellatif, Salomons, Gajja S., Somervaille, Tim C. P.
Publicado 2016

A TIAM1-TRIM28 complex mediates epigenetic silencing of protocadherins to promote migration of lung cancer cells

por Ginn, Lucy, Maltas, Joe, Baker, Martin J., Chaturvedi, Anshuman, Wilson, Leah, Guilbert, Ryan, Amaral, Fabio M. R., Priest, Lynsey, Mole, Holly, Blackhall, Fiona, Diamantopoulou, Zoi, Somervaille, Tim C. P., Hurlstone, Adam, Malliri, Angeliki
Publicado 2023

Phosphorylation of the Leukemic Oncoprotein EVI1 on Serine 196 Modulates DNA Binding, Transcriptional Repression and Transforming Ability

por White, Daniel J., Unwin, Richard D., Bindels, Eric, Pierce, Andrew, Teng, Hsiang-Ying, Muter, Joanne, Greystoke, Brigit, Somerville, Tim D., Griffiths, John, Lovell, Simon, Somervaille, Tim C. P., Delwel, Ruud, Whetton, Anthony D., Meyer, Stefan
Publicado 2013